Intravenous administration of L-tryptophan stimulates gastrointestinal hormones and melatonin secretions: study on beef cattle
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This study aimed to determine the effective dose of intravenous administration of L-tryptophan (L-T) on gastrointestinal hormones (GIH) secretions and melatonin using Hanwoo cattle. Three steers (362 ± 23 kg) fitted with indwelling jugular vein catheters were assigned in a 3 × 3 Latin square design. Treatments were intravenous administration of saline (control), 28.9 mg L-T/kg body weight (BW; low) and 57.8 mg L-T/kg BW (high) L-T for 1 day with 7 days of adaptation. Samples were collected after adaptation period at –60, 0, 30, 60, 90, 120, 150, 180, 240, and 300 min of sampling day. The levels of serum cholecystokinin (CCK) and secretin were higher (p < 0.05) in the high L-T group than those in the other groups. Serum Melatonin (MEL) levels were increased upon L-T administration (p < 0.05) in the high L-T group. Taken together, the effective dose of L-T administration was defined at 57.8 mg L-T/kg BW in order to stimulate increase of GIH and MEL.
Abstract
This study aimed to determine the effective dose of intravenous administration of L-tryptophan (L-T) on gastrointestinal hormones (GIH) secretions and melatonin using Hanwoo cattle. Three steers (362 ± 23 kg) fitted with indwelling jugular vein catheters were assigned in a 3 × 3 Latin square design. Treatments were intravenous administration of saline (control), 28.9 mg L-T/kg body weight (BW; low) and 57.8 mg L-T/kg BW (high) L-T for 1 day with 7 days of adaptation. Samples were collected after adaptation period at –60, 0, 30, 60, 90, 120, 150, 180, 240, and 300 min of sampling day. The levels of serum cholecystokinin (CCK) and secretin were higher (p < 0.05) in the high L-T group than those in the other groups. Serum Melatonin (MEL) levels were increased upon L-T administration (p < 0.05) in the high L-T group. Taken together, the effective dose of L-T administration was defined at 57.8 mg L-T/kg BW in order to stimulate increase of GIH and MEL.
참고문헌 (24)
- Guzik AC, "Dietary tryptophan effects on plasma and salivary cortisol and meat quality in pigs", J Anim Sci, 84, pp.2251~2259 (2006)
- S.B. Lee, "Effect of Oral Administration of Intact Casein on Gastrointestinal Hormone Secretion and Pancreatic α-Amylase Activity in Korean Native Steer", Animal Bioscience, 26(5), pp.654~660 (2013), 아세아·태평양축산학회[DOI]
- Kasuya E, "A possible role of central serotonin in L-tryptophan-induced GH secretion in cattle", Anim Sci J, 81, pp.345~351 (2010)
- Seeve B., "Tryptophan, serotonin, and melatonin: basic aspects and applications", pp.1999, Academic
- Ma H, "Effects of rumen-protected tryptophan on performance, nutrient utilization and plasma tryptophan in cashmere goats", Afr J Biotechnol, 10, pp.5806~5811 (2011)
- Alkozi HA, "Docking studies for melatonin receptors", Expert Optin Drug Discov, 13, pp.241~248 (2018)
- Bello AU, "Gut microbiota and transportation stress response affected by tryptophan supplementation in broiler chickens", Ital J Anim Sci, 17, pp.107~113 (2018)
- Liang H, "Dietary L-tryptophan modulates the structural and functional composition of the intestinal microbiome in weaned piglets", Front Microbiol, 9, pp.1~12 (2018)
- Leja-Szpak A, "Modulation of pancreatic enzyme secretion by melatonin and its precursor; L-tryptophan. Role of CCK and afferent nerves", J Physiol Pharmacol, 55(Suppl 2), pp.33~46 (2004)
- Montgomery GW, "Tryptophan deficiency in pigs : changes in food intake and plasma levels of glucose, amino acids, insulin and growth hormone", Horm Metab Res, 12, pp.304~309 (1980)
- Henry Y, "Interactive effects of dietary levels of tryptophan and protein on voluntary feed intake and growth performance in pigs, in relation to plasma free amino acids and hypothalamic serotonin", J Anim Sci, 70, pp.1873~1887 (1992)
- Charney DS, "The effect of intravenous L-tryptophan on prolactin and growth hormone and mood in healthy subjects", Psychopharmacol, 77, pp.217~222 (1982)
- Jaworek J., "Ghrelin and melatonin in the regulation of pancreatic exocrine secretion and maintaining of integrity", J Physiol Pharmacol, 57(Suppl 5), pp.83~96 (2006)
- Kyung-Hoon Lee, "Identification of proteins involved in the pancreatic exocrine by exogenous ghrelin administration in Sprague-Dawley rats", 한국축산학회지, 56(2), pp.1~10 (2014), 한국축산학회
- National Institute of Animal Science, "Korean feeding standard for Hanwoo", pp.158~ (2007), Rural Development Administration
- Association of Official Analytical Chemists, "Official methods of analysis of AOAC" (1980), AOAC
- National Academies of Sciences, Engineering, and Medicine, "Nutrient requiremnets of beef cattle", pp.406~ (2016), The National Academies Press
- Jaworek J, "Melatonin and its precursor, L-tryptophan : influence on pancreatic amylase secretion in vivo and in vitro", J Pineal Res, 36, pp.155~164 (2004)
- Zhang H, "Tryptophan enhances ghrelin expression and secretion associated with increased food intake and weight gain in weanling pigs", Domest Anim Endocrinol, 33, pp.47~61 (2007)
- Arnold MA, "L-Tryptophan injection enhances pulsatile growth hormone secretion in the rat", Endocrinol, 108, pp.331~335 (1981)
- Brunetti L, "Effects of ghrelin and amylin on dopamine, norepinephrine and serotonin release in the hypothalamus", Eur J Pharmacol, 454, pp.189~192 (2002)
- Ipharraguerre IR, "Impacts of the source and amount of crude protein on the intestinal supply of nitrogen fractions and performance of dairy cows", J Dairy Sci, 1, pp.E22~E37 (2005)
- Go VL, "Pancreozymin bioassay in man based on pancreatic enzyme secretion : potency of specific amino acids and other digestive products", J Clin Invest, 49, pp.1558~1564 (1970)
- Hashimoto N, "Dietary branched-chain amino acids suppress the expression of pancreatic amylase mRNA in rats", Biosci Biotechnol Biochem, 68, pp.1067~1072 (2004)