본문 바로가기
KERD
논문KCI 등재

金銀花가 Bleomycin에 의한 肺纖維化에 미치는 影響

The Effects of Lonicerae Flos on bleomycin-induced lung fibrosis

정희재|이형구|정승기|이재성
대한한방내과학회 (The Society Of Korean Oriental Internal Medicine)|2004.03|대한한방내과학회지 (The Journal of Korean Oriental Internal Medicine)|제25권 제1호|pp. 71-80

2

조회

0

다운로드

3

인용

0

참고문헌

주제분류한의학

초록

Abstract

Background & Objective : Idiopathic Lung Fibrosis(IPF) is chronic fibrotic interstitial pneumonia. The pathogenesis is unclear. Lonicerae Flos is known to prevent the inflammation and reinforce the immune system. The effects of Lonicerae Flos on bleomycin-induced lung fibrosis is evaluated. Material and Methods : Lonicerae Flos extract was daily given to the Normal rats, control(bleomycin) rats and Treated(bleomycin and lonicerae flos) rats 21.0 mg per body weight 10g for 14 days. 14 days after, we observed the change of leukocyte count and percentage, IFN-gamma and IL-4 in BALF. and of Semiquantative histological index(SHI). Results : Compared to control rats, Lonicerae Flos decreased leukocyte count(P<0.01) lymphocyte, neutrophil percentage(P<0.05), SHI(P<0.01), IFN-gamma and IL-4(P<0.05) in Treated rats. Otherwise, macrophage percentage was increased(P<0.01) in Treated rats. Conclusion : This study showed that Lonicerae Flos reduced the change of inflammatory cells and cytokines in bleomycin-induced lung fibrosis and reduced the fibrosis of tissue. And, we needed many other distinct researches on lung fibrosis.

참고문헌 (61)

  1. "순천향대학교 의과대학 내과학교실.폐섬유화증의 병인 및 병태생리", 54(2), pp.167~177 (2003)
  2. "Idiopathic pulmonary fibrosis :prevailing and evolving hypotheses about its pathogenesis and implications for therapy", 134, pp.136~151 (2001)
  3. "Bleomycin-induced lung injury is enhanced by interferon-alpha", 60(26), pp.415~421 (1997)
  4. "백서에서 Bleomycin 투여로 인한 폐손상 및 폐섬유화에 대한 Vitamin E의 영향", 42(2), pp.184~205 (1995)
  5. "中西醫結合呼吸病診療學", pp.211~224 (1995), 南海出版公司
  6. "補氣通肺湯治療特發性肺纖維化12例", 34(2), pp.54~55 (1999)
  7. "常見呼吸系疾病中西醫結合診斷與治療", pp.243~251 (1998), 中國醫藥科技出版社
  8. "對譯 證脈方藥合編", pp.210~ (1978), 南山堂
  9. "접촉성 피부염에서 황련,황련해독탕, 금은화가 림프구 활성에 미치는 영향" (2000)
  10. "Effect of immunomodulators on bleomycin-induced lung injury", 66(5), pp.455~462 (1999)
  11. "The effect of enoxaparin on bleomycin-induced lung injury in mice", 25(6), pp.531~541 (1999)
  12. "Bleomycin-induced lung injury is enhanced by interferon-", 60, pp.415~421 (1997)
  13. "Peribronchial lymphocyte activation in bleomycin-induced lung injury", 63, pp.1183~1193 (1998)
  14. "金銀花의 약리작용에 관한 硏究", pp.~18 (1983)
  15. "금은화 및 어성초가 인체 암세포주에 미치는 영향", 10(1), pp.126~132 (1996)
  16. "한국산 생약으로부터 항암물질의 개발 금은화 Ethyl Acetate 가용성 분획의 인체 구강유상피암종세포에 미치는 세포독성작용", 29(1), pp.22~27 (1998)
  17. "금은화 약침액의 암세포성장 저해 효과", 3, pp.65~73 (1998)
  18. "금은화 약침액의 암예방효과", 30(3), pp.261~268 (1999)
  19. "Idiopathic pulmonary fibrosis : diagnosis and treatment. International consensus statement. American Thoracic Society(ATS) and the European Respiratory Society(ERS)", 161, pp.646~664 (2000)
  20. "臨床呼吸器學", pp.240~251 (1998), 一潮閣
  21. "東醫肺系內科學", pp.400~409 (2002), 한문화
  22. "특발성 간질성폐렴의 방사선학적 소견", 54(2), pp.129~144 (2003)
  23. "특발성 간질성 폐렴의 분류 및 병리학적 소견 결핵 및 호흡기질환", 54(2), pp.145~166 (2003)
  24. "특발성 간질성폐렴의 진단적 접근방법", 54(3), pp.251~259 (2003)
  25. "특발성폐섬유증(IPF)의 치료.", 54(3), pp.260~273 (2003)
  26. "Cyclosporin A upmodulates bleomycin-induced pulmonary fibrosis in BALB", c mice, 2002, pp.69(4), 344~349
  27. "Altered accessory cell function of alveolar macrophages:a possible mechanism for induction of Th2 secretory profile in idiopathic pulmonary fibrosis", 10(4), pp.787~794 (1997)
  28. "Peribronchial lymphocyte activation in bleomycin-induced lung injury", 63(13), pp.1183~1193 (1998)
  29. "Lymphokines in bleomycin-induced lung injury in bleomycin-sensitive C57BL", 6 and -resistant BALB, pp.2000oct, 26(7)[DOI]
  30. "Different cytokine profiles in cryptogenic fibrosing alveolitis and fibrosing alveolitis associated with systemic sclerosis a quantitative study of open lung biopsies", 14(2), pp.251~257 (1999)
  31. "IL-7 inhibits fibroblast TGF-beta production and signaling in pulmonary fibrosis", 109(7), pp.931~937 (2002)
  32. "Activated T cells and cytokines in bronchoalveolar lavages from patients with various lung diseases associated with eosinophilia", 150(4), pp.1038~48 (1994)
  33. "IL-12 attenuates bleomycin-induced pulmonary fibrosis", 281(1), pp.92~97 (2001)
  34. "The expanding universe of T-cell subsets;Th1, Th2 and more", 17, pp.138~147 (1996)
  35. "Therapeutic effect of IL-13 immunoneutralization during chronic experimental fungal asthma", 166(8), pp.5219~5224 (2001)
  36. "Protection of iron-catalysed the radical damage to DNA and lipids by copper", pp.1354~60 (1981)
  37. "Bleomycin에 의한 폐손상의 기전에 관한 형태학적 硏究", 12, pp.127~ (1979)
  38. "Bleomycin의 기관내 투여로 유발된 폐장의 간질성 섬유증식증의 實驗적 硏究", 12, pp.158~ (1979)
  39. "Unraveling pulmonary fibrosis:the bleomycin model", 50(5), pp.487~8
  40. "Effect of antibody against integrin alpha4 on bleomycin-induced pulmonary fibrosis in mice", 60(12), pp.1949~1958 (2000)
  41. "PG490-88,a derivative of triptolide,blocks bleomycin-induced lung fibrosis", 158(3), pp.997~1004 (2001)
  42. "Mechanisms of drug-induced pulmonary disease", 39, pp.395~404 (1988)
  43. "Mechanisms of neutrophil accumulation in the lungs of patients with idiopathic pulmonary fibrosis", 68(1), pp.259~69 (1981)
  44. "The role of macrophage-derived chemoattractant activities in the early inflammatory events of bleomycin-induced pulmonary injury", 128(1), pp.132~7 (1983)
  45. "Time course of bleomycin-induced lung fibrosis", 83(3), pp.111~119 (2002)
  46. "폐포대식세포의 시험관내 자극이 폐섬유화에 미치는 영향", 8(1), pp.27~33 (1996)
  47. "Occurrence of neuron specific enolase in tumour tissue and serum in small cell lung cancer", 63(1), pp.151~3 (1991)
  48. "Telomerase activity and Bcl-2 expression in non-small cell lung cancer", 6(8), pp.2980~2987 (2000)
  49. "Monocyte chemotactic protein gene expression by cytokine-treated human fibroblasts and endothelial cells", 162, pp.694~700 (1989)
  50. "Selective inhibition of collagen gene expression in fibroblasts by an interferon-gamma transgene", 25, pp.199~215 (1999)
  51. "Proteoglycan expression in bleomycin lung fibroblasts role of transforming growth factor-beta(1) and interferon-gamma.", 283(4), pp.~814 (2002)
  52. "IFN-gamma-inducible protein-10 attenuates bleomycin-induced pulmonary fibrosis via inhibition of angiogenesis", 163(10), pp.5686~5692 (1999)
  53. "A profibrotic function of IL-12p40 in experimental pulmonary fibrosis", 169(5), pp.2653~2661 (2002)
  54. "Secretion of stem cell factor by alveolar fibroblasts in interstitial lung diseases", 67(3), pp.229~236 (1999)
  55. "Interleukin-4 and interferon-gamma discordantly regulate collagen biosynthesis by functionally distinct lung fibroblast subsets", 167(2), pp.290~296 (1996)
  56. "A type 2 (Th2-like) pattern of immune response predominates in the pulmonary interstitium of patients with cryptogenic fibrosing alveolitis(CFA)", 101(3), pp.436~441 (1995)
  57. "T cell independence of bleomycin-induced pulmonary fibrosis", 65(2), pp.187~195 (1999)
  58. "The Role of Interferon-{gamma} in the Evolution of Murine Bleomycin Lung Fibrosis", 285(6), pp.1255~1262 (2003)
  59. "Attenuation of lung inflammation and fibrosis in interferon-gamma-deficient mice after intratracheal bleomycin", 24(5), pp.545~555 (2001)
  60. "Dual roles of IL-4 in lung injury and fibrosis", 170(4), pp.2083~2092 (2003)
  61. "Attenuation of bleomycin-induced pneumopathy in mice by monoclonal antibody to interleukin-12", 280(6), pp.1128~1137 (2001)

관련 논문AI추천

숙지황이 Bleomycin에 의한 폐섬유화에 미치는 영향류한천, 이형구, 정승기, 정희재대한한방내과학회 · 대한한방내과학회지2004 · 제25권 제2호前胡가 Bleomycin에 의한 폐 섬유화에 미치는 영향김현지, 박은정, 이해자대한한방소아과학회 · 대한한방소아과학회지2008 · 제22권 제2호가미보중익기탕과 가미좌귀음의 폐 섬유화 치료 기전에 대한 예비 연구신권성, 안재선, 이해자대한한방소아과학회 · 대한한방소아과학회지2010 · 제24권 제1호방사선 조사에 의한 폐손상에서 Angiotensin-1 Converting Enzyme Inhibitor (Captopril)의 폐섬유화의 경감 효과권건영, 권선영, 김옥배, 김진희, 정혜라대한병리학회 · Journal of Pathology and Translational Medicine2004 · 제38권 제3호금은화가 LPS로 유발된 급성 폐 손상에 미치는 영향김종대, 박미연, 이창건, 최해윤대한예방한의학회 · 대한예방한의학회지2011 · 제15권 제1호淸肺化痰湯의 抗炎作用에 대한 實驗的 硏究곽상호, 김수민, 김의일, 신선미, 유동열, 이정은대한한방부인과학회 · 대한한방부인과학회지2007 · 제20권 제1호

이 간행물의 다른 논문 (9건)

맥문동이 생쥐의 기아 스트레스에 미치는 영향고호연, 박종형, 김동우, 전찬용, 백은기, 박지윤, 한양희, 임영남, 한지완, 전성하, 홍의실pp. 1-15骨碎補 ethanol 추출물의 면역조절 작용에 관한 연구이기억, 정지천pp. 16-27茵蔯淸肝湯이 kupffer cell의 inflammatory cytokine 발현에 미치는 영향우홍정, 이장훈, 김영철, 김지권pp. 46-58淸肝解酒湯이 kupffer cell의 NFkB 활성화 및 세포사멸에 미치는 영향우홍정, 김영철, 이장훈, 한창우pp. 59-70淸肝解酒湯이 인체간세포의 Glutathione 생성에 미치는 영향김영철, 이장훈, 우홍정, 윤여광pp. 81-91
원문 보기