益胃湯의 Indomethacin유발 위점막 손상에 대한 효과
The effects of Ikwitang extract on Indomethacin-induced Gastric Mucosal Lesions
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Abstract
This study was carried out to investigate the effects of Ikwitang extract on indomethacin-induced gastric mucosal lesions in mice. Experimental groups were classified into a non-treated group(NM group), a non-administered group(CON group), the Misoprostol-administered group(MI group) and the Ikwitang-extract-administered group(IW group). This study examined the morphological change, distribution of mast cells, mucous surface cells, acid mucose secreted cells, and apoptic cells, BrdU, COX-1, Hsp70, NF-κB p50, PKC, COX-2 and IL-12B of gastric mucosa. Results : The results of this study were as follows: 1. In the Misoprostol-administered group and the Ikwitang-extract-administered group, the hemorrhagic erosion of gastric mucous and infiltrated mast cells decreased. 2. Mucous surface cells and acid mucose secreted cells abserved in the Misoprostol-administered group and the Ikwitang-extract-administered group. 3. The distribution of apoptic cells, Hsp70, NF-κB p50, PKC, COX-2, and IL-12B increased in the Control group, but decreased in the Misoprostol-administered group and Ikwitang-extract-administered group. 4. Cell proliferation of gastric mucosa and the COX-1 positive cells decreased in the Control group, but increased in the Misoprostol-administered group and the Ikwitang-extract-administered group. The above results suggest the Ikwitang extract had beneficial effects on indomethacin induced gastric mucosal lesions
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