眞武湯이 백서의 갑상선기능저하증에 미치는 영향
Effects of Jinmutang (JMT) on Hypothyroidism in Rats
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Abstract
Objectives : This study was done to investigate the effects of JMT on hypothyroidism in rats.Materials and Methods : After pretreatment with 50㎎/㎏ thiouracil for 30 days, the experimental group was treated with 0.56g/㎏ JMT orally and the control group was treated with 0.56g/㎏ of normal saline instead for 20 days. The various indicators related to hypothyroidism were measured, such as T3-uptake content, T3 content, T4 content, TSH content, hematological values, enzyme activity, total cholesterol content, Na+ content change in the serum and body weight of rats induced by thiouracil.Results : The JMT-treated group showed significant increase in comparison with the control group in serum T3-uptake and T4 content. The JMT-treated group also showed significant decrease in comparison with the control group in serum TSH content. However, the JMT-treated group did not show significant increase in comparison with the control group in serum T3 content.The JMT-treated group showed significant increase in comparison with the control group in serum RBC. The JMT-treated group showed significant decrease in comparison with the control group in serum CPK, ALP, LDH content and serum total cholesterol content. The JMT-treated group did not show significant increase in comparison with the control group in serum Na+ content.The JMT-treated group showed significant decrease in comparison with the control group in body weight.Conclusions : These results suggest that JMT is useful in treatment of hypothyroidism.
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