본문 바로가기
KERD
논문KCI 등재

비폐색성 위 전정부 확장이 있는 흰쥐의 위 수축력, 체중 및 위 형태 복원에 대한 苓桂朮甘湯과 補中益氣湯의 효능

Effect of Youngkaechulgam-tang and Bojoongikki-tang on Gastric Contractility, Body Weight, and Gastric Morphology in Rats with Non-obstructive Antral Dilation

윤상협|정용재
대한한방내과학회 (The Society Of Korean Oriental Internal Medicine)|2010.12|대한한방내과학회지 (The Journal of Korean Oriental Internal Medicine)|제31권 제4호|pp. 857-869

2

조회

0

다운로드

7

인용

0

참고문헌

키워드

Herbal medicineratbowel soundgastric contractilityAntral dilation
주제분류한의학

초록

Objectives : The aim of this study was to evaluate whether rats with non-obstructive antral dilation could be a useful tool resembling functional dyspeptic patients. We also investigated the effect of Bojoongikki-tang (BJ), and Youngkaechulgam-tang (YK) in antral dilated rats. Methods : Non-obstructive antral dilation was performed by first wrapping a non-absorbable rubber ring (D:6mm, W:4mm, T:1mm) around the 1st portion of the duodenum causing pyloric obstruction (PO). After 12 weeks, except for some PO group rats used for the control, the rubber ring was removed by performing another operation. The antral dilated rats (AD) were then divided into three groups, a non-treatment group (AD-NT), and two herbal medicine groups each given an extract solution containing 125 mg/kg of Youngkaechulgam-tang (AD-YK) or Bojoongikki-tang (AD-BJ) for 4 weeks. Then gastric contractility was evaluated by bowel sound measurement, and afterwards the changes of the weight, and morphologic changes of the stomach were evaluated for each group including the normal intact group (NI). Results : Loss of weight and enlargement of the stomach surface area was seen in the PO group. Decrease of gastric motility index was observed in the AD-NT group, while the increased surface area of the stomach was not significantly different from the PO group. Youngkaechulgam-tang seemed to increase gastric contraction, whereas Bojoongikki-tang showed no effect. Weight gain of rats was observed in both the AD-YK and AD-BJ groups, but there seemed to be no change of the dilated stomach surface area. Conclusions : The non-obstructive antral dilated rat seems to be an experimental pathologic model that reflects the gastric dysmotility similar to functional dyspeptic patients with antral dilation. Therefore patients with dysmotility-like dyspepsia with antral function disorders should be treated efficiently. As Youngkaechulgam-tang is shown to increase both gastric contraction and weight in antral dilated rats, it may be used for treating functional dyspepsia. However, Bojoongikki-tang should be used with caution in patients with gastric dysmotility.

Abstract

Objectives : The aim of this study was to evaluate whether rats with non-obstructive antral dilation could be a useful tool resembling functional dyspeptic patients. We also investigated the effect of Bojoongikki-tang (BJ), and Youngkaechulgam-tang (YK) in antral dilated rats. Methods : Non-obstructive antral dilation was performed by first wrapping a non-absorbable rubber ring (D:6mm, W:4mm, T:1mm) around the 1st portion of the duodenum causing pyloric obstruction (PO). After 12 weeks, except for some PO group rats used for the control, the rubber ring was removed by performing another operation. The antral dilated rats (AD) were then divided into three groups, a non-treatment group (AD-NT), and two herbal medicine groups each given an extract solution containing 125 mg/kg of Youngkaechulgam-tang (AD-YK) or Bojoongikki-tang (AD-BJ) for 4 weeks. Then gastric contractility was evaluated by bowel sound measurement, and afterwards the changes of the weight, and morphologic changes of the stomach were evaluated for each group including the normal intact group (NI). Results : Loss of weight and enlargement of the stomach surface area was seen in the PO group. Decrease of gastric motility index was observed in the AD-NT group, while the increased surface area of the stomach was not significantly different from the PO group. Youngkaechulgam-tang seemed to increase gastric contraction, whereas Bojoongikki-tang showed no effect. Weight gain of rats was observed in both the AD-YK and AD-BJ groups, but there seemed to be no change of the dilated stomach surface area. Conclusions : The non-obstructive antral dilated rat seems to be an experimental pathologic model that reflects the gastric dysmotility similar to functional dyspeptic patients with antral dilation. Therefore patients with dysmotility-like dyspepsia with antral function disorders should be treated efficiently. As Youngkaechulgam-tang is shown to increase both gastric contraction and weight in antral dilated rats, it may be used for treating functional dyspepsia. However, Bojoongikki-tang should be used with caution in patients with gastric dysmotility.

참고문헌 (38)

  1. 양선영, "위식도역류질환 환자의 식이 위험요인 및 삶의 질", 대한내과학회지, 70(6), pp.627~635 (2006), 대한내과학회
  2. 이풍렬, "Dyspepsia 를 주소로 내원한 환자들의 원인에 대한 고찰", 대한소화관운동학회지, 4(2), pp.112~117 (1998)
  3. 이광재, "기능성 소화불량증의 병태생리와 치료", 대한 소화관 운동학회지, 9, pp.85~91 (2003)
  4. Loreno M, "Pattern of gastric emptying in functional dyspepsia", An ultrasonographic study. Dig Dis Sci, 49, pp.404~407 (2004)
  5. Hausken T, "Wide gastric antrum in patients with non-ulcer dyspepsia", Effect of cisapride. Scand J Gastroenterol, 27, pp.427~432 (1992)
  6. Bolondi L, "Measurement of gastric emptying time by real-time ultrasonography", Gastroenterology, 89, pp.752~759 (1985)
  7. Pallotta N, "Relationship between antral distension and postprandial symptoms in functional dyspepsia", World J Gastroenterol, 12(43), pp.6982~6991 (2006)
  8. Riezzo G, "Comparison of gastric electrical activity and gastric emptying in healthy and dispeptic children", Dig Dis Sci, 45(3), pp.517~524 (2000)
  9. Fujimiya M, "Different effects of ghrelin, des-acyl ghrelin and obestatin on gastroduodenal motility in conscious rats", World J Gastroenterol, 14(41), pp.6318~6326 (2008)
  10. 花輪壽彦, "한방진료의 LESSON", pp.113~ (2001), 고려의학
  11. Ohno T, "The roles of motilin and ghrelin in gastrointestinal motility", Int J Pept. Epub 2010, ~ (2010), article ID 820794
  12. 한숙영, "二陳湯이 정상 및 위 유문부가 부분폐색된 흰 쥐의 위 운동성에 미치는 효과", 대한한방내과학회지, 30(1), pp.107~118 (2009), 대한한방내과학회
  13. 김진석, "內消散의 정상 및 위 유문부 확장 흰 쥐의 위 운동성에 대한 효능", 대한한방내과학회지, 29(1), pp.117~129 (2008), 대한한방내과학회
  14. 홍인아, "足三里穴 전침 자극이 유문부 부분폐색이 된 흰 쥐의 胃 배출능에 미치는 효능", 대한한방내과학회지, 30(1), pp.1~8 (2009), 대한한방내과학회
  15. 노의준, "고방유취", pp.195~ (2009), 복치의학회출판국
  16. 조기호, "임상 한방의학", pp.41~ (2009), 신훙메드싸이언스
  17. 황황, "중의십대유방", pp.161~ (2004), 집문당
  18. 전국한의과대학 비계내과학교실, "비계내과학", pp.348~ (2008), 군자출판사
  19. 박영선, "補中益氣湯, 十全大補湯, 苓桂b>甘", b>이 장음으로 평가된 흰 쥐의 胃 收縮力에 미치는 영향, 2010, pp.31(2), 212~223[DOI]
  20. Omura N, "Changes in gastric hormones associated with gastric outlet obstruction. An experimental study in rats", Scand J Gastroenterol, 28, pp.568~572 (1993)
  21. Cruz MT, "A reevaluation of the effects of stimulation of the dorsal motor nucleus of the vagus on gastric motility in the rat", Am J Physiol Regul Integr Comp Physiol., 292(1), pp.291~307 (2007)
  22. 원종만, "六君子湯이 흰쥐의 胃 排出能에 미치는 영향", 대한한방내과학회지, 28(2), pp.242~249 (2007), 대한한방내과학회
  23. Ricci R, "Dyspeptic symptoms and gastric antrum distribution. An ultrasonographic study", Ital J Gastroenterol., 19, pp.215~217 (1987)
  24. Avenhaus W, "Gastric wall elasticity assed by dynamic endoscopy: ex vivo investigations in the porcine stomach", Gastrointest Endosc, 54(4), pp.496~500 (2001)
  25. Egorov V, "Mechanical properties of the human gastrointenstinal tract", J Biomech, 35(10), pp.1417~1425 (2002)
  26. Kamino D, "Long-term Ultrasonographic Follow-up Study of Gastric Motility in Patients with Functional Dyspepsia", J. Clin Biochem Nutr., 42(2), pp.144~149 (2008)
  27. 홍인아, "기능성 소화불량증 환자의 위장관 부교감 신경, 위 유문부의 기능 및 임상양상에 대한 조사 (한방병원 내원 환자를 중심으로)", 대한한방내과학회지, 29(3), pp.666~674 (2008), 대한한방내과학회
  28. 김유승, "기능성 소화불량증 환자의 위 미주신경 활성 및 유문부 기능에 대한 足三里 전침과 일반 체침 자극의 복합 효능", 대한한방내과학회지, 29(3), pp.621~628 (2008), 대한한방내과학회
  29. Tomomasa T, "Gastrointestinal sounds and migrating motor complex in fasted humans", Am J Gastroenterol., 94(2), pp.374~381 (1999)
  30. Yamaguchi K, "Evaluation of gastrointestinal motility by computerized analysis of abdominal auscultation findings", J Gastroenterol Hepatol, 21(3), pp.510~514 (2006)
  31. 문영명, "Patholphysiology로 이해하는 내과학, 소화기질환", pp.141~142 (2002), 정담
  32. Troncon L, "Abnormal intragastric distribution of food during gastric emptying in functional dyspepsia patients", Gut, 35, pp.327~332 (1994)
  33. Matsuo H, "Impaired gastric compliance is related to weight loss in severe motility-like dyspeptic patients", Gastroenterology, 106, pp.A537~ (1994)
  34. Le KJ, "Pathophysiology of functional dyspepsia", Best Pract Res Clin Gastroenterol, 18(4), pp.707~716 (2004)
  35. 中山醫學院, "한약임상응용", pp.343~344 (1982), 성보사
  36. 張介賓, "景岳全書", pp.29~ (1999), 정담
  37. 전국 한의과대학 본초학 교수, "본초학", pp.534~ (2000), 영림사
  38. 許浚, "東醫寶鑑", pp.1201~1289 (2005), 동의보감출판사

관련 논문AI추천

內消散의 정상 및 위 유문부 확장 흰 쥐의 위 운동성에 대한 효능김진석, 윤상협대한한방내과학회 · 대한한방내과학회지2008 · 제29권 제1호補中益氣湯, 十全大補湯, 苓桂朮甘湯이 장음으로 평가된 흰 쥐의 胃 收縮力에 미치는 영향박영선, 윤상협대한한방내과학회 · 대한한방내과학회지2010 · 제31권 제2호枳朮丸 Extract가 깨어있는 흰쥐의 위 수축력에 미치는 영향강경, 윤상협대한한방내과학회 · 대한한방내과학회지2013 · 제34권 제2호枳朮丸의 흰쥐 胃 運動性에서 정상 상태 및 위벽 국소손상 후에 대한 효능윤상협, 이승우대한한방내과학회 · 대한한방내과학회지2008 · 제29권 제1호二陳湯이 정상 및 위 유문부가 부분폐색된 흰 쥐의 위 운동성에 미치는 효과윤상협, 한숙영대한한방내과학회 · 대한한방내과학회지2009 · 제30권 제1호二陳湯이 STZ 誘發 糖尿病 흰쥐의 胃 運動性에 미치는 影響윤상협, 허원영대한한방내과학회 · 대한한방내과학회지2008 · 제29권 제1호

이 간행물의 다른 논문 (19건)

大七氣湯이 Glutamate에 의한 C6 Glial 세포의 Apoptosis에 미치는 영향이동엽, 방창호, 고석재, 이인, 신선호, 김혜윤pp. 693-705흰쥐의 손상된 뇌조직에서의 유전자 발현 변화에 대한 紅花 추출물 투여의 작용조수인, 김부여, 이금산, 임세현, 김형우, 임지연pp. 706-713청폐사간탕(淸肺瀉肝湯)의 혈소판 응집억제 작용에 대한 in vitro 연구이미정, 이우경, 이지숙, 류재환, 강덕희, 양가은, 김영찬, 박영주, 김슬지pp. 714-721임상연구의 효과적인 대상자 모집 전략 - 기능성 소화불량증 임상시험 자료에 대한 분석 -김진성, 고석재, 류봉하, 박재우, 한가진, 정의민, 오승환pp. 722-730四君子湯이 TNBS로 誘發된 생쥐의 炎症性 腸疾患에 미치는 影響홍상선, 윤성우, 김진성, 류봉하pp. 731-751
원문 보기