기능성 소화불량증 환자에서 로마기준 Ⅲ 아형분류 및 脾氣虛證과 심상유두 수의 상관성 분석
Fungiform Papillae and its Correlation with Rome III Classification and Spleen Qi Deficiency in Functional Dyspepsia
1
조회
0
다운로드
2
인용
0
참고문헌
키워드
초록
Objectives: Whether there exists a distinct pathogenesis in subgroups of functional dyspepsia (FD), the classification of epigastric pain syndrome (EPS), and postprandial distress syndrome (PDS) remains controversial. We aimed to investigate the number of fungiform papillae (FP) in the subgroups of FD and its correlation with the severity of dyspepsia symptoms and spleen qi deficiency. Methods: Patients with FD were enrolled from August to November 2014. All patients were evaluated using a questionnaire and divided into 2 groups according to the Rome Ⅲ criteria for FD. The severity of dyspepsia symptoms and spleen qi deficiency were separately assessed by Nepean Dyspepsia Index-Korean (NDI-K) version and Spleen qi deficiency questionnaire (SQDQ). The number of FP was measured on the anterior part of tongue, within an area of 9 mm2, using a digital camera. Results: The NDI-K score, SQDQ score, and number of FP in the EPS group were significantly greater than those in the PDS group. Also, the EPS group had more patients diagnosed with spleen qi deficiency. The number of FP showed a significant positive correlation with epigastric pain and burning. Furthermore, the number of FP was significantly associated with the score of some items in NDI-K and SQDQ, even though not with the total score. Conclusions: Thus, measurement of the number of FP could be a new evaluation indicator for allocation into FD subtypes and to investigate the severity of dyspepsia symptoms and spleen Qi deficiency reflecting visceral hypersensitivity.
Abstract
Objectives: Whether there exists a distinct pathogenesis in subgroups of functional dyspepsia (FD), the classification of epigastric pain syndrome (EPS), and postprandial distress syndrome (PDS) remains controversial. We aimed to investigate the number of fungiform papillae (FP) in the subgroups of FD and its correlation with the severity of dyspepsia symptoms and spleen qi deficiency. Methods: Patients with FD were enrolled from August to November 2014. All patients were evaluated using a questionnaire and divided into 2 groups according to the Rome Ⅲ criteria for FD. The severity of dyspepsia symptoms and spleen qi deficiency were separately assessed by Nepean Dyspepsia Index-Korean (NDI-K) version and Spleen qi deficiency questionnaire (SQDQ). The number of FP was measured on the anterior part of tongue, within an area of 9 mm2, using a digital camera. Results: The NDI-K score, SQDQ score, and number of FP in the EPS group were significantly greater than those in the PDS group. Also, the EPS group had more patients diagnosed with spleen qi deficiency. The number of FP showed a significant positive correlation with epigastric pain and burning. Furthermore, the number of FP was significantly associated with the score of some items in NDI-K and SQDQ, even though not with the total score. Conclusions: Thus, measurement of the number of FP could be a new evaluation indicator for allocation into FD subtypes and to investigate the severity of dyspepsia symptoms and spleen Qi deficiency reflecting visceral hypersensitivity.
참고문헌 (30)
- Mahadeva S, "Epidemiology of functional dyspepsia: a global perspective", World J Gastroenterol, 12(17), pp.2661~2666 (2006)
- Lee EH, "Development and validation of a functional dyspepsia-related quality of life(Fd-Qol) scale in South Korea", J Gastroenterol Hepatol, 1, pp.268~274 (2006)
- Tack J, "Functional gastroduodenal disorders", Gastroenterology, 130(5), pp.1466~1479 (2006)
- Talley NJ, "Functional gastroduodenal disorders", Gut, 45(Suppl2), pp.II37~II42 (1999)
- 박종규, "기능성 소화불량증의 최근 동향", 대한소화기학회지, 64(3), pp.133~141 (2014), 대한소화기학회
- Shindo T, "Comparison of gastric emptying and plasma ghrelin levels in patients with functional dyspepsia and non-erosive reflux disease", Digestion, 79(2), pp.65~72 (2009)
- Talley NJ, "Non-ulcer dyspepsia and duodenal eosinophilia: an adult endoscopic population-based case-control study", Clin Gastroenterol Hepatol, 5(10), pp.1175~1183 (2007)
- Ahmed AB, "Rome Ⅲ subgroups of functional dyspepsia exhibit different characteristics of antral contractions measured by strain rate imaging - a pilot study", Ultraschall Med, 33(7), pp.E233~E240 (2012)
- 이봉교, "한방진단학", pp.41~ (1992), 성보사
- Segovia C, "A quantitative study of fungiform papillae and taste pore density in adults and children", Dev Brain Res, 138(2), pp.135~146 (2002)
- Camacho-Alonso F, "Fungiform papillae density in patients with burning mouth syndrome and xerostomia", Med Oral Patol Oral Cir Bucal, 17(3), pp.e362~e366 (2012)
- 裵秉哲, "今釋黃帝內經 ≪素問≫", pp.75~103 (2012), 성보사
- 윤창열, "難經硏究集成", pp.634~647 (2007), 주민출판사
- 한방병리학 교재편찬위원회, "한방병리학", pp.411~414 (2008), 한의문화사
- 배선재, "소아 및 청소년에서 버섯 유두 개수로 산출한 설 미뢰 밀도와 식습관의 상관성 연구", 대한한방소아과학회지, 24(1), pp.1~8 (2010), 대한한방소아과학회
- Wang RF, "Temperature can influence gastric accommodation and sensitivity in functional dyspepsia with epigastric pain syndrome", Dig Dis Sci, 58(9), pp.2550~2555 (2013)
- Rita Brun, "Functional dyspepsia", Ther Adv Gastroenterol, 3(3), pp.145~164 (2010)
- Talley NJ, "Development of a new dyspepsia impact scale: the Nepean Dyspepsia Index", Aliment Pharmacol Ther, 13(2), pp.225~235 (1999)
- Lee SY, "Validation of the Nepean Dyspepsia Index- Korean version", Kor J Neruogastroenterol Motil, 9(suppl), pp.48~ (2003)
- 오혜원, "脾氣虛證 진단평가도구 개발 연구", 대한한의학회지, 35(1), pp.157~170 (2014), 대한한의학회
- Maryam Shahbake, "Rapid quantitative assessment of fungiform papillae density in the human tongue", Brain Research, 1052(2), pp.196~201 (2005)
- Hu WH, "Functional(non-ulcer) dyspepsia:unexplained but not unmanageable", Med J Aust, 168(10), pp.507~512 (1998)
- 정혜경, "기능성 소화불량증의 진단: 배제진단 vs. 절대진단", 대한내과학회지, 78(2), pp.163~169 (2010), 대한내과학회
- Miller SL, "Electrogustometric threshold: Relationship to anterior tongue locus, area of stimulation, and number of fungiform papillae", Physiol Behav, 75(5), pp.753~757 (2002)
- 한동훈, "젊은 성인에서 심상유두개수와 전기미각역치의 상관성", Journal of Oral Medicine and Pain, 36(1), pp.1~10 (2011), 대한안면통증∙구강내과학회
- Voiosu TA, "Functional dyspepsia today", Maedica (Buchar), 8(1), pp.68~74 (2013)
- 박재명, "Functional Gastrointestinal Disorders Diagnosed by Rome III Questionnaire in Korea", Journal of Neurogastroenterology and Motility (JNM), 17(3), pp.279~286 (2011), 대한소화기 기능성질환∙운동학회
- 조유경, "기능성 소화불량증의 삶의 질에 대한 모사프리드의 효과", 대한소화기학회지, 43(3), pp.160~167 (2004), 대한소화기학회
- Yackinous CA, "Relation between PROP(6-n-propylthiouracil) taster status, taste anatomy and dietary intake measures for young men and women", Appetite, 38, pp.201~209 (2002)
- Yeomans MR, "Human hedonic responses to sweetness: Role of taste genetics and anatomy", Physiol Behav, 91, pp.264~273 (2007)