한방병원에 입원한 노인암 환자의 치료 특성 분석
Analysis of Clinical Characteristics and Treatments among Geriatric Cancer Patients Hospitalized in a Traditional Korean Medical Hospita
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Objective: Because the number of geriatric cancer patients is on the rise but information on treatments for this population is limited, this study aimed to analyze clinical characteristics and the factors that influence treatment decisions among elderly cancer patients. Method: Data on elderly cancer patients (≥65 years of age) who were admitted to a traditional Korean medicine hospital from March 2014 to February 2016 were collected. We compared the clinical characteristics and overall survival rates of the chemotherapy group and the non-chemotherapy group. Results: Nineteen patients were included in this study. Nine people received chemotherapy, and ten people did not receive chemotherapy due to concerns about quality of life. Age, activities of daily living (ADL) score, and Eastern Cooperative Oncology Group (ECOG) performance status all showed differences between the two groups, although median survival times did not differ significantly between the two. Compared with chemotherapy alone, traditional Korean medicine combined with chemotherapy prolonged median survival times. Conclusion: Old age and low ECOG performance status and ADL scores appear to be influential factors for the decision to undergo chemotherapy. Further studies are needed to confirm that these factors influence decisions about cancer treatment methods among geriatric cancer patients.
Abstract
Objective: Because the number of geriatric cancer patients is on the rise but information on treatments for this population is limited, this study aimed to analyze clinical characteristics and the factors that influence treatment decisions among elderly cancer patients. Method: Data on elderly cancer patients (≥65 years of age) who were admitted to a traditional Korean medicine hospital from March 2014 to February 2016 were collected. We compared the clinical characteristics and overall survival rates of the chemotherapy group and the non-chemotherapy group. Results: Nineteen patients were included in this study. Nine people received chemotherapy, and ten people did not receive chemotherapy due to concerns about quality of life. Age, activities of daily living (ADL) score, and Eastern Cooperative Oncology Group (ECOG) performance status all showed differences between the two groups, although median survival times did not differ significantly between the two. Compared with chemotherapy alone, traditional Korean medicine combined with chemotherapy prolonged median survival times. Conclusion: Old age and low ECOG performance status and ADL scores appear to be influential factors for the decision to undergo chemotherapy. Further studies are needed to confirm that these factors influence decisions about cancer treatment methods among geriatric cancer patients.
참고문헌 (18)
- "U.S. Census Bureau projections show a slower growing, older, more diverse nation a half century from now"[URL]
- "National Cancer Information Center"[URL]
- Hutchins LF, "Underrepresentation of patients 65 years of age or older in cancer-treatment trials", N Engl J Med, 341(27), pp.2061~2067 (1999)
- Folprecht G, "Irinotecan", Fuorouracil combination in first-line therapy of older and younger patients with metastatic colorectal cancer: combined analysis of 2,691patients in randomized controlled trials, 2008, pp.26(9), 1443~1451
- Miguchi M, "Chemotherapeutic outcomes for metastatic colorectal cancer in elderly patients aged≥75years: A single-institutional retrospective analysis", Asia Pac J Clin Oncol, 12(2), pp.151~158 (2016)
- Malfuson JV, "Risk factors and decision criteria for intensive chemotherapy in older patients with acute myeloid leukemia", Haematologica, 93(12), pp.1806~1813 (2008)
- Hamaker ME, "Baseline comprehensive geriatric assessment is associated with toxicity and survival in elderly metastatic breast cancer patients receiving single-agent chemotherapy: Results from the OMEGA study of the Dutch Breast Cancer Trialists’ Group", Breast, 23(1), pp.81~87 (2014)
- Presley C, "The Treatment of Advanced Lung Cancer in the Elderly : The Role of a Comprehensive Geriatric Assessment and Doublet Chemotherapy", Cancer J, 21(5), pp.392~397 (2015)
- Hurria A, "Management of elderly patients with cancer", J Natl Compr Canc Netw, 11, pp.698~701 (2013)
- Park SY, "Safety and efficacy of adjuvant therapy after surgery of elderly colon cancer patients 70 years of age or older", Master, Dept. of Medicine, pp.2015
- Shin GY, "Study on current use of chemotherapy in elderly patients with colorectal cancer", Master, Dept. of Clinical Health Science, pp.2012
- 이정숙, "입원환자를 위해 개발된 영양검색 도구의 타당성 검증", Journal of Nutrition and Health, 43(2), pp.189~196 (2010), 한국영양학회
- Jatoi A, "Older versus younger patients with metastatic adenocarcinoma of the esophagus, gastroesophagealjunction, and stomach : a pooled analysis of eight consecutive North Central Cancer Treatment Group(NCCTG) trials", Int J Oncol, 36, pp.601~606 (2010)
- Saif MW, "Chemotherapy options and outcomes in older adult patients with colorectal cancer", Crit Rev Oncol Hematol, 72, pp.155~169 (2009)
- de Kock I, "Conversion of Karnofsky Performance Status(KPS) and Eastern Cooperative Oncology Group Performance Status(ECOG)to Palliative Performance Scale(PPS), and the interchangeability of PPS and KPS in prognostic tools", J Palliat Care, 29(3), pp.163~169 (2013)
- Ommundsen N, "Frailty is an independent predictor of survival in older patients with colorectal cancer", Oncologist, 19(12), pp.1268~1275 (2014)
- Maltoni M, "Prognostic factors in advanced cancer patients: evidence-based clinical recommendations-a study by the Steering Committee of the European Association for Palliative Care", J Clin Oncol, 23, pp.6240~6248 (2005)
- Qi F, "The advantages of using traditional Chinese medicine as an adjunctive therapy in the whole course of cancer treatment instead of only terminal stage of cancer", Biosci Trends, 9(1), pp.16~34 (2015)