감태(Ecklonia cava)를 이용한 자외선 차단 필름의 UV-B 조사에 의한 광손상으로부터 보호효과
Protective Effects of Ecklonia cava Film on UV-B-induced Photodamages
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Exposure to ultraviolet (UV) radiation is associated with the development of adverse effects in skin. Among the threetypes of UV rays, UV-B causes the most damaging effects, inducing sunburn and penetrating the outer skin, resultingin DNA mutations and skin cancer. The objective of this study was to formulate a UV-protective film by incorporatingEcklonia cava extracts. Cells covered with the film were exposed to UV-B (50, 80, and 100 mJ/cm2). To determine theprotective effects of the film, we evaluated cell viability, intracellular ROS generation, and apoptosis. We found thatall E. cava extracts absorbed UV light and exhibited protective effects against UV-B-induced photodamage. Amongthe protective films examined in this study, that incorporating an E. cava 70% ethanol extract (70EX) formed the mosteffective protection against UV-B in HaCaT cells. These findings suggest that the application of film containing E. cava extract could prevent UV-B-induced photodamage, and offer protection against the detrimental effects of UVradiation, thus maintaining physiological condition.
Abstract
Exposure to ultraviolet (UV) radiation is associated with the development of adverse effects in skin. Among the threetypes of UV rays, UV-B causes the most damaging effects, inducing sunburn and penetrating the outer skin, resultingin DNA mutations and skin cancer. The objective of this study was to formulate a UV-protective film by incorporatingEcklonia cava extracts. Cells covered with the film were exposed to UV-B (50, 80, and 100 mJ/cm2). To determine theprotective effects of the film, we evaluated cell viability, intracellular ROS generation, and apoptosis. We found thatall E. cava extracts absorbed UV light and exhibited protective effects against UV-B-induced photodamage. Amongthe protective films examined in this study, that incorporating an E. cava 70% ethanol extract (70EX) formed the mosteffective protection against UV-B in HaCaT cells. These findings suggest that the application of film containing E. cava extract could prevent UV-B-induced photodamage, and offer protection against the detrimental effects of UVradiation, thus maintaining physiological condition.
참고문헌 (20)
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