옥시벤존(Benzophenone-3)이 돌돔(Oplegnathus fasciatus)의 배 발생 과정에 미치는 영향
Effect of Oxybenzone (Benzophenone-3) on Rock Bream Oplegnathus fasciatus, Embryo Development
0
조회
0
다운로드
0
인용
0
참고문헌
키워드
초록
Oxybenzone (Benzophenone-3; BP-3) is a compound used in sunscreens and enters the oceans due to improper disposal. It is known to disrupt the endocrine signaling in marine organisms, leading to immune and reproductive abnormalities in corals, shellfish and fishes. In this study, we investigated the effects of different concentrations of BP-3 (0, 10, 100 and 1,000 μg/L) on the fertilized eggs and hatched larvae of Oplegnathus fasciatus. The morphological changes and hatching and survival rates during embryo development were assessed. In addition, the levels of triiodothyronine (T3) were also measured. The hatched larvae exposed to BP-3 at concentrations of 10 and 100 μg/L for 24 h displayed malformation of the tail. After 36 h of exposure to BP-3, spinal deformity was observed at all tested concentrations. The hatching rate was significantly low when exposed to 100 μg/L of BP-3. A high levels of T3 was observed when the larvae were exposed to BP-3 at a concentration of 1,000 μg/L for 96 h (the end of the experiment). This may be related to increased size of larvae at 1,000 μg/L BP-3. In conclusion, our results suggested that BP-3 may interfere with embryo development, resulting in a reduction in hatching rate and malformation of larvae.
Abstract
Oxybenzone (Benzophenone-3; BP-3) is a compound used in sunscreens and enters the oceans due to improper disposal. It is known to disrupt the endocrine signaling in marine organisms, leading to immune and reproductive abnormalities in corals, shellfish and fishes. In this study, we investigated the effects of different concentrations of BP-3 (0, 10, 100 and 1,000 μg/L) on the fertilized eggs and hatched larvae of Oplegnathus fasciatus. The morphological changes and hatching and survival rates during embryo development were assessed. In addition, the levels of triiodothyronine (T3) were also measured. The hatched larvae exposed to BP-3 at concentrations of 10 and 100 μg/L for 24 h displayed malformation of the tail. After 36 h of exposure to BP-3, spinal deformity was observed at all tested concentrations. The hatching rate was significantly low when exposed to 100 μg/L of BP-3. A high levels of T3 was observed when the larvae were exposed to BP-3 at a concentration of 1,000 μg/L for 96 h (the end of the experiment). This may be related to increased size of larvae at 1,000 μg/L BP-3. In conclusion, our results suggested that BP-3 may interfere with embryo development, resulting in a reduction in hatching rate and malformation of larvae.
참고문헌 (24)
- Balázs A, "Hormonal activity, cytotoxicity and developmental toxicity of UV filters", Ecotoxicol Environ Saf, 131, pp.45~53 (2016)[DOI]
- Blanton ML, "The hypothalamic-pituitarythyroid(HPT)axis in fish and tts role in fish development and reproduction", Crit Rev Toxicol, 37, pp.97~115 (2007)[DOI]
- Blüthgen N, "Effects of the UV filter benzophenone-3(oxybenzone)at low concentrations in zebrafish(Danio rerio)", Toxicol App Pharmacol, 263, pp.184~194 (2012)[DOI]
- Bošnjak I, "Quantification and in situ localisation of abcb1 and abcc9 genes in toxicant-exposed sea urchin embryos", Environ Sci Pollut Res, 20, pp.8600~8611 (2013)[DOI]
- Brausch JM, "A review of personal care products in the aquatic environment : Environmental concentrations and toxicity", Chemosphere, 82, pp.1518~1532 (2011)[DOI]
- Carletta MA, "Development of thyroid abnormalities in mummichogs, Fundulus heteroclitus, from a polluted site", Mar Environ Res, 54, pp.601~604 (2002)[DOI]
- Coronado M, "Estrogenic activity and reproductive effects of the UV-filter oxybenzone(2-hydroxy-4-methoxyphenyl-methanone)in fish", Aquat Toxicol, 90, pp.182~187 (2008)[DOI]
- Deal CK, "The role of the thyroid axis in fish", Front Endocrinol, 11, pp.596585~ (2020)[DOI]
- Downs CA, "Oxybenzone contamination from sunscreen pollution and its ecological threat to Hanauma Bay, Oahu, Hawaii, U.S.A.", Chemosphere, 291, pp.132880~ (2022)[DOI]
- "EWG’s Skin Deep" (2018)[URL]
- "House of Representatives Thirty-first Legislature, 2021" (2021)[URL]
- 강덕영, "감성돔, Acanthopagrus schlegeli 수정란과 부화자어의 발달에 미치는 3,5,3'-triiodo-L-thyronine (T3)의 침지처리 효과", 생명과학회지, 13(1), pp.34~41 (2003), 한국생명과학회
- Keer S, "Anatomical assessment of the adult skeleton of zebrafish reared under different thyroid hormone profiles", Anat Rec, 302, pp.1754~1176 (2019)[DOI]
- Li MH, "Acute toxicity of benzophenone-type UV filters and paraben preservatives to freshwater planarian, Dugesia japonica", Toxicol Environ Chem, 94, pp.566~573 (2012)[DOI]
- Lopes FC, "Effect of the UV filter, Benzophenone-3, on biomarkers of the yellow clam (Amarilladesma mactroides) under different pH conditions", Mar Pollut Bull, 158, pp.111401~ (2020)[DOI]
- Molins-Delgado D, "Single and joint ecotoxicity data estimation of organic UV filters and nanomaterials toward selected aquatic organisms. Urban groundwater risk assessment", Environ Res, 145, pp.126~134 (2016)[DOI]
- "Skincare Chemicals and Coral Reefs" (2021)[URL]
- O'Malley E, "The presence of selected UV filters in a freshwater recreational reservoir and fate in controlled experiments", Sci Total Environ, 754, pp.142373~ (2021)[DOI]
- Ozáez I, "The UV filter benzophenone 3 (BP-3) activates hormonal genes mimicking the action of ecdysone and alters embryo development in the insect Chironomus riparius (Diptera)", Environ Pollut, 192, pp.19~26 (2014)[DOI]
- Paredes E, "Ecotoxicological evaluation of four UV filters using marine organisms from different trophic levels Isochrysis galbana, Mytilus galloprovincialis, Paracentrotus lividus, and Siriella armata", Chemosphere, 104, pp.44~50 (2014)[DOI]
- "Opinion on Benzophenone-3 Final Version of 30-31 March 2021" (2021)[URL]
- Schnitzler JG, "Thyroid dysfunction in sea bass (Dicentrarchus labrax): Underlying mechanisms and effects of polychlorinated biphenyls on thyroid hormone physiology and metabolism", Aquat Toxicol, 105, pp.438~447 (2011)[DOI]
- Thorel E, "Effect of 10 UV filters on the brine shrimp Artemia salina and the marine Microalga Tetraselmis sp", Toxics, 8, pp.29~ (2020)[DOI]
- Wijgerde T, "Adding insult to injury: Effects of chronic oxybenzone exposure and elevated temperature on two reef-building corals", Sci Total Environ, 733, pp.139030~ (2020)[DOI]