지충이(Sargassum thunbergii) 추출물의 피부노화 및 고혈압 억제활성
Anti-skin Aging and Antihypertensive Activities of Different Solvent Extracts from Sargassum thunbergii
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In this study, we investigated the physiological activities of the Korean marine algae Sargassum thunbergii employing the solvent extracts prepared with 70% ethanol, 80% methanol, and water. The extraction yields of different solvents ranged between 6.40% and 26.19%. The total polyphenol and flavonoid contents ranged from 94.90 to 117.56 mg/g and 17.37 to 20.23 mg/g, respectively. For anti-skin aging activity, evaluation of the skin whitening and anti-wrinkle activities showed that the methanol extract exhibited the highest tyrosinase (half-maximal inhibitory concentration, IC50, 0.50 mg/mL), elastase (IC50, 0.30 mg/ mL), and collagenase (IC50, 3.72 mg/mL) inhibitory activities. The ethanolic and methanolic extracts demonstrated higher angiotensin-converting enzyme (ACE) inhibitory activity against the aqueous extract. These results indicate that S. thunbergii has promising anti-skin aging and antihypertensive activities in food and cosmetic products.
Abstract
In this study, we investigated the physiological activities of the Korean marine algae Sargassum thunbergii employing the solvent extracts prepared with 70% ethanol, 80% methanol, and water. The extraction yields of different solvents ranged between 6.40% and 26.19%. The total polyphenol and flavonoid contents ranged from 94.90 to 117.56 mg/g and 17.37 to 20.23 mg/g, respectively. For anti-skin aging activity, evaluation of the skin whitening and anti-wrinkle activities showed that the methanol extract exhibited the highest tyrosinase (half-maximal inhibitory concentration, IC50, 0.50 mg/mL), elastase (IC50, 0.30 mg/ mL), and collagenase (IC50, 3.72 mg/mL) inhibitory activities. The ethanolic and methanolic extracts demonstrated higher angiotensin-converting enzyme (ACE) inhibitory activity against the aqueous extract. These results indicate that S. thunbergii has promising anti-skin aging and antihypertensive activities in food and cosmetic products.