향사평위산의 항염증 효과 및 이상지질혈증 개선 작용에 대한 연구
A Study on the Anti-Inflammatory Effect and Improvement of Dyslipidemia on Hyangsapyeongwi-san
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Objectives: This study aims to investigate the anti-inflammatory effect and improvement of dyslipidemia on Hyangsapyeongwi-san. Methods: In this study, HUVEC cells were cultured and treated with Hyangsapyeongwi-san to measure intracellular KLF2, eNOS, MCP-1, ICAM-1, and VCAM-1 gene expression levels related to anti-inflammation. The weight of experimental animals administered with Hyangsapyeongwi-san was measured, blood samples were biochemically analyzed, and liver tissues were reviewed to research histological changes. Results: Gene expression levels in the cells treated with Hyangsapyeongwi-san generally showed a meaningful anti-inflammatory effect. The body weight of the experimental animals decreased, and total cholesterol, triglyceride, and LDL-cholesterol in the blood generally declined while HDL-cholesterol tended to increase. Fat accumulation between hepatocytes was also reduced after the administration of Hyangsapyeongwi-san. Conclusions: This study confirmed that Hyangsapyeongwi-san has the effect of suppressing vascular inflammatory responses through the regulation of genes involved in the vascular inflammatory process and improving dyslipidemia through the reduction of blood lipids and weight loss.
Abstract
Objectives: This study aims to investigate the anti-inflammatory effect and improvement of dyslipidemia on Hyangsapyeongwi-san. Methods: In this study, HUVEC cells were cultured and treated with Hyangsapyeongwi-san to measure intracellular KLF2, eNOS, MCP-1, ICAM-1, and VCAM-1 gene expression levels related to anti-inflammation. The weight of experimental animals administered with Hyangsapyeongwi-san was measured, blood samples were biochemically analyzed, and liver tissues were reviewed to research histological changes. Results: Gene expression levels in the cells treated with Hyangsapyeongwi-san generally showed a meaningful anti-inflammatory effect. The body weight of the experimental animals decreased, and total cholesterol, triglyceride, and LDL-cholesterol in the blood generally declined while HDL-cholesterol tended to increase. Fat accumulation between hepatocytes was also reduced after the administration of Hyangsapyeongwi-san. Conclusions: This study confirmed that Hyangsapyeongwi-san has the effect of suppressing vascular inflammatory responses through the regulation of genes involved in the vascular inflammatory process and improving dyslipidemia through the reduction of blood lipids and weight loss.
참고문헌 (28)
- "Cardiovascular diseases (CVDs)"[URL]
- Korea Health Statistics 2020: Korea National Health and Nutrition Examination Survey (KNHANES Ⅷ-2), "Korea Centers for Disease Control and Prevention", Korea Centers for Disease Control and Prevention, 22~23 (2022)
- Korean Medical Guideline Information Center, "Evidence-based Guideline for Dyslipidemia in Primary Care(Rev. ed.)", Korean Academy of Medical Sciences, 3~ (2022)
- Jameson JL, "Harrison's Principles of Internal Medicine", pp.1665~ (2018), Mcgrawhill Education
- 이은정, "2018 Guidelines for the Management of Dyslipidemia in Korea", 지질·동맥경화학회지, 8(2), pp.78~131 (2019), 한국지질동맥경화학회[DOI]
- Kong JH, "Jeungbo Manbyeonghoechun", pp.105~108 (2001), Seil
- Ju YS., "Ungok Herbology", pp.359~362 (2013), Woosuk Press
- Jang IG, "Experimental Studies on the Efficacy of Pyungwee-san, Hyangsapyungwee-san and Bylwhanhgumchunggi-san", Journal of KyungHee Oriental Medicine College, 13(1), pp.427~461 (1990)
- 최흥민, "Indomethacin으로 유발된 생쥐의 위 점막 손상에 대한 香砂平胃散의 보호 효과", 대한한방내과학회지, 25(3), pp.518~528 (2004), 대한한방내과학회
- 임선희, "香砂平胃散 藥鍼液의 자유기 소거활성 및 혈관내피세포의 산화적 손상에 대한 보호효과", Korean Journal of Acupuncture, 25(1), pp.113~130 (2008), 경락경혈학회
- Statistics Korea, "Statistics on Causes of Death in 2020", Statistics Korea, 6~10 (2021)
- O'Donnell CJ, "Cardiovascular Risk Factors. Insights From Framingham Heart Study", Rev Esp Cardiol, 61(3), pp.299~310 (2008)
- National Cholesterol Education Program Expert Panel on Detection, Evaluation, and Treatment of High Blood Cholesterol in Adults, "Third Report of the National Cholesterol Education Program Expert Panel on Detection, Evaluation, and Treatment of High Blood Cholesterol in Adults Final Report", Circulation, 106(25), pp.3143~3421 (2002)
- Prevalence and Management of Dyslipidemia in Koreans, "Ahn JH", Korea Centers for Disease Control and Prevention, 1296~1299 (2018)
- Tonkin A, "Treatment of Dyslipidemia", F1000Prime Rep, 6, pp.17~ (2014)
- Bae BC, "Geumseok Hwangjaenaegyeong", pp.305~315 (1995), Seongbosa
- 유주영, "茵蔯, 鬱金, 枳實 추출물(ACA)이 HepG2 세포에서 나타나는 이상지질혈증 관련 인자 발현 및 항산화에 미치는 영향", 대한한방내과학회지, 38(3), pp.367~375 (2017), 대한한방내과학회
- 박창호, "고지방식이를 섭취한 흰쥐에서 진피 에탄올추출물이 혈청지질 및 체지방에 미치는 영향", Food Science and Preservation, 18(4), pp.567~574 (2011), 한국식품저장유통학회
- National Oriental Medical Department of Heart Internal Medicine, "Korean Medicine Neurocirculatory Internal Medicine", pp.184~189 (2010), Gunja publishing company
- Kim JC, "SIM Integral Medicine Part Ⅲ : Cardiology", pp.203~211 (2013), Jungdam
- Han JM, "Soy-leaf Extract Exerts Atheroprotective Effects via Modulation of Krüppel-like Factor 2 and Adhesion Molecules", Int J Mol Sci, 18(2), pp.373~ (2017)
- Channon KM, "Nitric Oxide Synthase in Atherosclerosis and Vascular Injury : Insights From Experimental Gene Therapy", Arterioscler Thromb Vasc Biol, 20(8), pp.1873~1881 (2000)
- Christopherson K, "Chemokine Regulation of Normal and Pathologic Immune Responses", Stem cells, 19(5), pp.388~396 (2001)
- Grundy SM, "Multifactorial Causation of Obesity : Implications for Prevention", Am J Clin Nutr, 67(3), pp.563S~572S (1998)[DOI]
- Prevalence and Management of Hypercholesterolemia in Adults in Korea, "Kim DY", Korea Centers for Disease Control and Prevention, 1~5 (2021)
- Tomizawa M, "Triglyceride is Strongly Associated with Nonalcoholic Fatty Liver Disease Among Markers of Hyperlipidemia and Diabetes", Biomed Rep, 2(5), pp.633~636 (2014)
- Miller M, "Triglycerides and Cardiovascular Disease : A Scientific Statement from the American Heart Association", Circulation, 123(20), pp.2292~2333 (2011)
- 한지민, "Differing Associations between Fatty Liver and Dyslipidemia According to the Degree of Hepatic Steatosis in Korea", 지질·동맥경화학회지, 8(2), pp.258~266 (2019), 한국지질동맥경화학회[DOI]