항생제 치료에도 반복되는 기관지확장증 환자의 기관지폐렴에 대한 한양방 복합 치험 1례
Recurrent Bronchopneumonia in Bronchiectasis, Despite Antibiotic Treatment: A Case Report on Combined Treatment with Korean and Western Medicine
1
조회
0
다운로드
1
인용
0
참고문헌
키워드
초록
Background: Bronchiectasis is a chronic respiratory condition leading to recurrent respiratory infections. Despite the use of antibiotics and other standard treatments, managing bronchiectasis remains challenging due to the frequent recurrence of airway infections and concerns about antimicrobial resistance. Given these challenges, traditional Korean medicine (TKM) has gained attention due to its potential to reduce the frequency of respiratory infections, possibly minimizing the need for antibiotics. Case report: A 59-year-old female with bronchiectasis experienced recurrent pneumonia and was treated with antibiotics for over 2 weeks without any significant improvement in clinical symptoms. She received comprehensive Korean medicine treatment, including herbal medicine (Sikyungbanha-tang combined with Bigwabojungikki-tang-gami), acupuncture, and Chuna manual therapy, for pulmonary rehabilitation. Post-treatment, clinically meaningful improvements were observed in symptoms, serum C-reactive protein (CRP) levels, and bronchopneumonic lesions on chest X-rays. Conclusion: This case suggests that complex traditional Korean medicine treatments for recurrent chronic airway inflammation due to bronchiectasis can lead to clinically significant improvements in symptoms and help to prevent recurrence.
Abstract
Background: Bronchiectasis is a chronic respiratory condition leading to recurrent respiratory infections. Despite the use of antibiotics and other standard treatments, managing bronchiectasis remains challenging due to the frequent recurrence of airway infections and concerns about antimicrobial resistance. Given these challenges, traditional Korean medicine (TKM) has gained attention due to its potential to reduce the frequency of respiratory infections, possibly minimizing the need for antibiotics. Case report: A 59-year-old female with bronchiectasis experienced recurrent pneumonia and was treated with antibiotics for over 2 weeks without any significant improvement in clinical symptoms. She received comprehensive Korean medicine treatment, including herbal medicine (Sikyungbanha-tang combined with Bigwabojungikki-tang-gami), acupuncture, and Chuna manual therapy, for pulmonary rehabilitation. Post-treatment, clinically meaningful improvements were observed in symptoms, serum C-reactive protein (CRP) levels, and bronchopneumonic lesions on chest X-rays. Conclusion: This case suggests that complex traditional Korean medicine treatments for recurrent chronic airway inflammation due to bronchiectasis can lead to clinically significant improvements in symptoms and help to prevent recurrence.
참고문헌 (29)
- O'Donnell AE, "Bronchiectasis update", Curr Opin Infect Dis, 31(2), pp.194~198 (2018)
- Seo HW, "Clinical relevance of bronchiectasis in patients with community-acquired pneumonia", Am J Med Sci, 365(6), pp.502~509 (2023)
- Modi AR, "Community-acquired pneumonia : Strategies for triage and treatment", Cleve Clin J Med, 87(3), pp.145~151 (2020)
- Sfeir MM, "Diagnosis of Multidrug-Resistant Pathogens of Pneumonia", Diagnostics(Basel), 11(12), pp.2287~ (2021)
- Polverino E, "European Respiratory Society guidelines for the management of adult bronchiectasis", Eur Respir J, 50(3), pp.1700629~ (2017)
- Chalmers JD, "Bronchiectasis : new therapies and new perspectives", Lancet Respir Med, 6(9), pp.715~726 (2018)
- 전국한의과대학폐계내과학교실, "폐계내과학(수정판)", pp.356~357 (2024), 의방출판사
- Lee H, "Clinical approach to non-cystic fibrosis bronchiectasis based on recent clinical guideline", Korean J Med, 95(3), pp.141~150 (2020)
- 전국한의과대학 공동교재편찬위원회, "本草學" (2016), 영림사
- Park J, "The Effectiveness and Safety of Chuna Manual Therapy Adjuvant to Western Medicine in Patients with Chronic Obstructive Pulmonary Disease : A Randomized, Single-Blind, Investigator-Initiated, Pilot Trial", Healthcare(Basel), 12(2), pp.152~ (2024)
- Spinou A, "An update on measurement and monitoring of cough : what are the important study endpoints?", J Thorac Dis, 6(Suppl 7), pp.S728~S734 (2014)
- Yun YH, "Validation study of the Korean version of the brief fatigue inventory", J Pain Symptom Manage, 29(2), pp.165~172 (2005)
- Kim JW, "Validity Evidences of VAS Pain Scale Utilizing Objective Physical Activity Measures in Middle-Aged Females with Low-Back Pain", The Korean Journal of Measurement and Evaluation in Physical Education and Sport Science, 15(2), pp.29~39 (2013)
- Karakioulaki M, "Biomarkers in Pneumonia-Beyond Procalcitonin", Int J Mol Sci, 20(8), pp.2004~ (2019)
- Polverino Eva, "Microbiology and outcomes of community acquired pneumonia in non cystic-fibrosis bronchiectasis patients", Journal of Infection, 71(1), pp.28~36 (2015)
- Ramzi, N, "Bronchiectasis in common variable immunodeficiency: a systematic review and meta-analysis", Pediatric Pulmonology, 55(2), pp.292~299 (2020)
- Cui J, "Bu-Shen-Yi-Qi formula ameliorates airway remodeling in murine chronic asthma by modulating airway inflammation and oxidative stress in the lung", Biomedicine & Pharmacotherapy, 112, pp.108694~ (2019)
- Oshikiri T, "Postoperative recurrent laryngeal nerve palsy is associated with pneumonia in minimally invasive esophagectomy for esophageal cancer", Surg Endosc, 35(2), pp.837~844 (2021)
- Asaka S, "Postoperative Pneumonia After Esophagectomy and Systemic Inflammatory Response Syndrome", Anticancer Res, 39(2), pp.979~985 (2019)
- Lee SE, "Shigyungbanha-tang Exhibits Anti-inflammatory Effects by Inhibiting IκB-α Degradation in LPS-stimulated Peritoneal Macrophages", J Int Korean Med, 28(3), pp.442~452 (2007)
- Kim KT, "Effects of Shigyungbanha-Tang on the Lipopolysaccharide-Induced Acute Lung Injury in Mice", Journal of Physiology & Pathology in Korean Medicine, 23(6), pp.1349~1357 (2009)
- Park SR, "Differential Regulation of NF-κB and Nrf2 by Bojungikki-Tang Is Associated with Suppressing Lung Inflammation", Evid Based Complement Alternat Med, 2018, pp.5059469~ (2018)
- Chun J, "Bojungikki-Tang Improves Response to PD-L1 Immunotherapy by Regulating the Tumor Microenvironment in MC38 Tumor-Bearing Mice", Front Pharmacol, 13, pp.901563~ (2022)
- Kim Y, "Research trends of Lonicera japonica over the last 10 years", Journal of Haehwa Medicine, 19(1), pp.17~23 (2010)
- Ranneh Y, "Acute Inflammation and Oxidative Stress Induced by Lipopolysaccharide and the Ameliorative Effect of Stingless Bee Honey", Comb Chem High Throughput Screen, 24(6), pp.744~757 (2021)
- Kong M, "The Efficacy and Safety of Acupuncture for Preventing Radiation Pneumonitis in Patients With Lung Cancer : A Prospective, Single-Blinded, Randomized Pilot Proof-of-Principle Study", Integr Cancer Ther, 19, pp.1534735420908327~ (2020)
- McCarthy B, "Pulmonary rehabilitation for chronic obstructive pulmonary disease", Cochrane database of systematic reviews, 2015(2), pp.CD003793~ (2015)
- Lyu YR, "Application of Taesikbub and Lung-doyinbub in"Dong-Ui-Bo-Gam"as a Korean Traditional Pulmonary Rehabilitation Exercise", J Korean Med, 39(3), pp.41~50 (2018)
- Kim TH, "Chronic Obstructive Pulmonary Disease Patients Treated with Korean Medicine Pulmonary Rehabilitation : Two case reports", J Korean Med, 41(3), pp.162~172 (2020)