갑상선 결절에 대한 반하후박탕(半夏厚朴湯)가미방의 효과 : 체계적 문헌 고찰 및 메타 분석
The Effect of Banhahubak-tang-gami on Thyroid Nodules: A Systematic Review and Meta-Analysis
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Objective: The purpose of this study was to investigate the effect of Banhahubak-tang-gami on thyroid nodules through a systematic review and meta-analysis of randomized controlled trials (RCTs). Methods: An online search was conducted using keywords such as “thyroid nodule”, “Banhahubak-tang”, ‘‘BanxiaHoupo Decoction”, and “Pinellia and Officinal Magnolia Bark Decoction” in 11 databases (Pubmed, Cochrane, Embase, ScienceDirect, CNKI, CiNii, RISS, KISS, ScienceON, OASIS, and DBpia) on August 1, 2024. There were no limits on the publication period and language. A meta-analysis was conducted by synthesizing the result data, such as total effective rate (TER), maximum thyroid nodule diameter, TSH, and TCM symptom score (TSS), using RevMan web. The quality of the studies was evaluated using Cochrane’s risk of bias (RoB). Results: Five RCTs met the inclusion criteria. The meta-analysis revealed that the treatment group (Banhahubak-tang-gami or Banhahubak-tang-gami with Western medicine) showed a more statistically significant effect compared to the control group (Western medicine or non-treatment) in TER (RR: 1.62, 95% CI 1.10~2.38, P=0.02), maximum thyroid nodule diameter (RR: -2.85, 95% CI -4.62~-1.07, P=0.002), TSH(RR: -0.15, 95% CI -0.24~-0.07, P=0.00004), TSS(RR: -2.75, 95% CI -3.41~-2.09, P=0.0005). Conclusion: This study suggests that Banhahubak-tang-gami can be effective for treating thyroid nodules. However, the included studies appear to be of low quality and involve only small sample sizes, suggesting that additional research is necessary.
Abstract
Objective: The purpose of this study was to investigate the effect of Banhahubak-tang-gami on thyroid nodules through a systematic review and meta-analysis of randomized controlled trials (RCTs). Methods: An online search was conducted using keywords such as “thyroid nodule”, “Banhahubak-tang”, ‘‘BanxiaHoupo Decoction”, and “Pinellia and Officinal Magnolia Bark Decoction” in 11 databases (Pubmed, Cochrane, Embase, ScienceDirect, CNKI, CiNii, RISS, KISS, ScienceON, OASIS, and DBpia) on August 1, 2024. There were no limits on the publication period and language. A meta-analysis was conducted by synthesizing the result data, such as total effective rate (TER), maximum thyroid nodule diameter, TSH, and TCM symptom score (TSS), using RevMan web. The quality of the studies was evaluated using Cochrane’s risk of bias (RoB). Results: Five RCTs met the inclusion criteria. The meta-analysis revealed that the treatment group (Banhahubak-tang-gami or Banhahubak-tang-gami with Western medicine) showed a more statistically significant effect compared to the control group (Western medicine or non-treatment) in TER (RR: 1.62, 95% CI 1.10~2.38, P=0.02), maximum thyroid nodule diameter (RR: -2.85, 95% CI -4.62~-1.07, P=0.002), TSH(RR: -0.15, 95% CI -0.24~-0.07, P=0.00004), TSS(RR: -2.75, 95% CI -3.41~-2.09, P=0.0005). Conclusion: This study suggests that Banhahubak-tang-gami can be effective for treating thyroid nodules. However, the included studies appear to be of low quality and involve only small sample sizes, suggesting that additional research is necessary.
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