Pseudocirrhosis of Breast Cancer Metastases to the Liver Treated by Chemotherapy
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Pseudocirrhosis refers to a condition that shows changes in hepatic contour thatmimic cirrhosis radiographically in the absence of the typical histopathologicalfindings of cirrhosis. This condition has been observed in patients with cancermetastatic to the liver, both in those who have undergone prior systemic chemotherapyand those who have not. Pseudocirrhosis may cause difficulty in interpretationof the response to chemotherapy and hepatic decompression and complication ofportal hypertension have a negative effect on the prognosis. We report on a case ofbreast cancer with liver metastases that showed cirrhotic changes during diseaseprogression. Progression of liver metastases was confirmed by F18 fluorodeoxyglucosepositron emission tomography/computed tomography (PET-CT). We alsoperformed ultrasound-guided liver biopsy and confirmed tumor infiltration with severedesmoplastic fibrosis. This case suggests the pathogenesis of pseudocirrhosisthrough histopathological findings and the role of PET-CT in evaluation of the responseto chemotherapy in patients with pseudocirrhosis.
Abstract
Pseudocirrhosis refers to a condition that shows changes in hepatic contour thatmimic cirrhosis radiographically in the absence of the typical histopathologicalfindings of cirrhosis. This condition has been observed in patients with cancermetastatic to the liver, both in those who have undergone prior systemic chemotherapyand those who have not. Pseudocirrhosis may cause difficulty in interpretationof the response to chemotherapy and hepatic decompression and complication ofportal hypertension have a negative effect on the prognosis. We report on a case ofbreast cancer with liver metastases that showed cirrhotic changes during diseaseprogression. Progression of liver metastases was confirmed by F18 fluorodeoxyglucosepositron emission tomography/computed tomography (PET-CT). We alsoperformed ultrasound-guided liver biopsy and confirmed tumor infiltration with severedesmoplastic fibrosis. This case suggests the pathogenesis of pseudocirrhosisthrough histopathological findings and the role of PET-CT in evaluation of the responseto chemotherapy in patients with pseudocirrhosis.
참고문헌 (12)
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