Adherence to the Recommended Intake of Calcium and Colorectal Cancer Risk in the HEXA Study
2
조회
0
다운로드
1
인용
0
참고문헌
키워드
초록
Purpose Dietary calcium intake has been suggested to be protective against the development of colorectal cancer. The mean dietary calcium intake of Koreans is 490 mg/day, which is far below the recommended calcium intake of 700-800 mg/day. In this study, we explored the relationship between dietary calcium intake and colorectal cancer development in Koreans with relatively low calcium intake compared with individuals in Western countries. Materials and Methods The Health Examinees Study, a large-scale genomic community-based prospective cohort study, was designed to identify the general characteristics of major chronic diseases in Koreans. A total of 119,501 participants aged 40-69 years recruited between 2004 and 2013 were included in this analysis. The calcium intake level was categorized using the Dietary Reference Intakes for Koreans (KDRIs). The Cox proportional hazards regression model was used to estimate the hazard ratio (HR) and the corresponding 95% confidence intervals (CIs) for colorectal cancer risk, adjusting for potential confounders. Results In the multivariable-adjusted model, compared with the group that consumed less than the recommended amount of calcium, the group that consumed more than the recommended intake of calcium showed a significant reduction in the risk of colorectal cancer in women. (HR, 0.54; 95% CI, 0.31 to 0.95). Among men, however, no significant association was observed between dietary calcium intake and colorectal cancer risk (HR, 0.89; 95% CI, 0.54 to 1.45). Conclusion Korean women who adhere to the recommended intake of calcium showed a reduced risk of colorectal cancer.
Abstract
Purpose Dietary calcium intake has been suggested to be protective against the development of colorectal cancer. The mean dietary calcium intake of Koreans is 490 mg/day, which is far below the recommended calcium intake of 700-800 mg/day. In this study, we explored the relationship between dietary calcium intake and colorectal cancer development in Koreans with relatively low calcium intake compared with individuals in Western countries. Materials and Methods The Health Examinees Study, a large-scale genomic community-based prospective cohort study, was designed to identify the general characteristics of major chronic diseases in Koreans. A total of 119,501 participants aged 40-69 years recruited between 2004 and 2013 were included in this analysis. The calcium intake level was categorized using the Dietary Reference Intakes for Koreans (KDRIs). The Cox proportional hazards regression model was used to estimate the hazard ratio (HR) and the corresponding 95% confidence intervals (CIs) for colorectal cancer risk, adjusting for potential confounders. Results In the multivariable-adjusted model, compared with the group that consumed less than the recommended amount of calcium, the group that consumed more than the recommended intake of calcium showed a significant reduction in the risk of colorectal cancer in women. (HR, 0.54; 95% CI, 0.31 to 0.95). Among men, however, no significant association was observed between dietary calcium intake and colorectal cancer risk (HR, 0.89; 95% CI, 0.54 to 1.45). Conclusion Korean women who adhere to the recommended intake of calcium showed a reduced risk of colorectal cancer.
참고문헌 (31)
- Arnold M, "Global patterns and trends in colorectal cancer incidence and mortality", Gut, 66, pp.683~691 (2017)
- 정규원, "Cancer Statistics in Korea: Incidence, Mortality, Survival, and Prevalence in 2016", Cancer Research and Treatment, 51(2), pp.417~430 (2019), 대한암학회
- Continuous update project: keeping the science current. Colorectal cancer 2011 report: food, nutrition, physical activity and the prevention of colorectal cancer, "World Cancer Research Fund", World Cancer Research Fund, ~ (2011)
- Diet, nutrition, physical activity and colorectal cancer, "World Cancer Research Fund", World Cancer Research Fund, ~ (2017)
- Cho E, "Dairy foods, calcium, and colorectal cancer : a pooled analysis of 10 cohort studies", J Natl Cancer Inst, 96, pp.1015~1022 (2004)
- Han C, "Dietary calcium intake and the risk of colorectal cancer : a case control study", BMC Cancer, 15, pp.966~ (2015)
- Keum N, "Calcium intake and colorectal cancer risk : dose-response metaanalysis of prospective observational studies", Int J Cancer, 135, pp.1940~1948 (2014)
- National health statistics, "Korea Centers for Disease Control and Prevention", Korea Centers for Disease Control and Prevention, ~ (2018)
- Balk EM, "Global dietary calcium intake among adults : a systematic review", Osteoporos Int, 28, pp.3315~3324 (2017)
- Health Examinees Study Group, "The Health Examinees(HEXA)study : rationale, study design and baseline characteristics", Asian Pac J Cancer Prev, 16, pp.1591~1597 (2015)
- Shin S, "Association between milk consumption and metabolic syndrome among Korean adults : results from the health examinees study", Nutrients, 9, pp.1102~ (2017)
- Ahn Y, "Validation and reproducibility of food frequency questionnaire for Korean genome epidemiologic study", Eur J Clin Nutr, 61, pp.1435~1441 (2007)
- Newmark HL, "Colon cancer and dietary fat, phosphate, and calcium : a hypothesis", J Natl Cancer Inst, 72, pp.1323~1325 (1984)
- 정규원, "Cancer Statistics in Korea: Incidence, Mortality, Survival, and Prevalence in 2014", Cancer Research and Treatment, 49(2), pp.292~305 (2017), 대한암학회
- Meng Y, "Dietary intakes of calcium, iron, magnesium, and potassium elements and the risk of colorectal cancer : a meta-analysis", Biol Trace Elem Res, 189, pp.325~335 (2019)
- Mizoue T, "Calcium, dairy foods, vitamin D, and colorectal cancer risk : the Fukuoka Colorectal Cancer Study", Cancer Epidemiol Biomarkers Prev, 17, pp.2800~2807 (2008)
- Zhang X, "Higher intakes of dietary vitamin D, calcium and dairy products are inversely associated with the risk of colorectal cancer : a case-control study in China", Br J Nutr, 123, pp.699~711 (2020)
- Murphy N, "Consumption of dairy products and colorectal cancer in the European Prospective Investigation into Cancer and Nutrition(EPIC)", PLoS One, 8, pp.e72715~ (2013)
- Butler LM, "Prospective study of dietary patterns and colorectal cancer among Singapore Chinese", Br J Cancer, 99, pp.1511~1516 (2008)
- Kesse E, "Dietary calcium, phosphorus, vitamin D, dairy products and the risk of colorectal adenoma and cancer among French women of the E3N-EPIC prospective study", Int J Cancer, 117, pp.137~144 (2005)
- Tantamango-Bartley Y, "Independent associations of dairy and calcium intakes with colorectal cancers in the Adventist Health Study-2 cohort", Public Health Nutr, 20, pp.2577~2586 (2017)
- Valles X, "Colorectal cancer, sun exposure and dietary vitamin D and calcium intake in the MCC-Spain study", Environ Int, 121, pp.428~434 (2018)
- Major food sources of Na and Ca in Korea, "Korea Centers for Disease Control and Prevention", Centers for Disease Control and Prevention, ~ (2010)
- Braun M, "Racial differences in skeletal calcium retention in adolescent girls with varied controlled calcium intakes", Am J Clin Nutr, 85, pp.1657~1663 (2007)
- Chakrabarty S, "Extracellular calcium and calcium sensing receptor function in human colon carcinomas : promotion of E-cadherin expression and suppression of beta-catenin", TCF activation, 2003, pp.63, 67~71
- Ye CP, "Regulation of a Ca2+-activated K+ channel by calcium-sensing receptor involves p38 MAP kinase", J Neurosci Res, 75, pp.491~498 (2004)
- Allen LH, "Calcium bioavailability and absorption : a review", Am J Clin Nutr, 35, pp.783~808 (1982)
- Franceschi S, "Menopause and colorectal cancer", Br J Cancer, 82, pp.1860~1862 (2000)
- Fernandez E, "Oral contraceptives and colorectal cancer risk : a meta-analysis", Br J Cancer, 84, pp.722~727 (2001)
- Grodstein F, "Postmenopausal hormone therapy and the risk of colorectal cancer : a review and meta-analysis", Am J Med, 106, pp.574~582 (1999)
- Baker AH, "Sex differences in fruit and vegetable intake in older adults", Appetite, 40, pp.269~275 (2003)