본문 바로가기
KERD
논문KCI 등재

Prognostic Significance of Immunohistochemical Expression of p53 Gene Product in Operable Breast Cancer

2

조회

0

다운로드

0

인용

0

참고문헌

주제분류의학일반

초록

Abstract

Purpose: The aim of this study was to investigate the prognostic significance of the expression of p53 gene product in operable invasive breast cancer by performing immunohistochemical analysis. Materials and Methods: Between January 1993 and December 2001, 440 operable invasive breast cancer patients underwent immunohistochemical staining for p53, and we retrospectively analyzed these results together with the clinical outcomes. Results: The overexpression of p53 was detected in 51.6% of the cases. The overexpression of p53 was inversely correlated with lymph node metastasis (p=0.005). The tumor size, tumor histology, histologic grade, hormonal receptor status and tumor stage were not related to the overexpression of p53. Multivariate Cox regression analysis indicate that lymph node metastasis, tumor size and the p53 expression were the significant prognostic factors for overall survival; lymph node metastasis, the estrogen receptor status and the p53 expression were the significant prognostic factors for relapse free survival. On the subgroup analysis, the p53 non-expressors showed better 7-year overall survival (92.7% vs. 76.7%, respectively, p=0.011) and relapse free survival (74.9% vs. 57.8%, respectively, p=0.032) than did the p53 overexpressors for the patients with lymph node metastasis. However, for the patients without lymph node metastasis, the survival rates were not different for both the p53 non-expressors and the p53 overexpressors. Conclusion: Immunohistochemical staining of the p53 gene product was an independent prognostic factor for predicting survival of the lymph node positive invasive breast cancer patients. (Cancer Res Treat. 2006;38:218- 223)

참고문헌 (22)

  1. "Immunohistochemistry expression of mutant form of p53 oncogene in primary lung cancer. Lancet. 1990", prog(sis), pp.675~9
  2. "Levine AJ. The p53 proto-oncogene can act as a suppressor of transformation. Cell. 1989", pp.1083~93
  3. "et al. Relation between p53 overexpression and established prognostic factors in breast cancer. Surgery. 1991", pp.259~64
  4. "Levine AJ. Activating mutations for transformation by p53 produce a gene product that forms an hsc70-p53 complex with an altered half-life. Mol Cell Biol. 1988", pp.531~9
  5. "et al. Loss of heterozygosity of the p53 gene and p53 protein expression in human colorectal carcinomas. Cancer Res. 1991", pp.4436~42
  6. "et al. Overexpression and mutation of p53 in epithelial ovarian cancer. Cancer Res. 1991", pp.2979~84
  7. "Prognostic factors in breast cancer", 124, pp.966~978 (2000), College of American Pathologists
  8. "Association of overexpression of tumor suppressor protein p53 with rapid cell proliferation and poor prognosis in node-negative breast cancer patients1992", pp.1109~14
  9. "Milles RR. Immunohistochemical detection of p53 protein in mammary carcinoma an important new independent indicator of prognosis? Hum Pathol. 1993", pp.469~76
  10. "Syrjanen K. P53 protein expression in breast cancer as related to histopathological characteristics and prognosis. Int J Cancer. 1993", pp.51~6
  11. "P53 protein in 204 patients with primary breast carcinoma", 256, pp.139~146 (1995)
  12. "Expression of c-myc p53 and nm23-H1 gene product in benign and malignant breast lesions coexpression and correlation with clinicopathologic parameters.", 79, pp.42~50 (2005)
  13. "Adverse outcome and resistance to adjuvant antiestrogen therapy in node-positive postmenopausal breast cancer patients-The role of p53", 15, pp.69~75 (2006)
  14. "Usefulness of immunohistochemical staining for p53 in the prognosis of breast carcinomas", 57, pp.96~104 (1995)
  15. "Immunofluorometrically determined p53 accumulation as a prognostic indicator in Italian breast cancer patients", 79, pp.147~152 (1998)
  16. "TP53 mutation is an independent prognostic marker for poor outcome in both node-negative and node-positive breast cancer . 2000", 39, pp.327~333 (2000)
  17. "p53 in node-negative breast carcinoma", 13, pp.821~830 (1995)
  18. "Spectrum of p53 tumor suppressor gene mutations and breast cancer survival", 83, pp.57~66 (2004)
  19. "Somatic mutations in the p53 gene and prognosis in breast cancer", 80, pp.1968~1973 (1999)
  20. "P53 status predicts survival in breast cancer patients treated with or without postoperative radiotherapy", 13, pp.2745~2751 (1995)
  21. "Prognostic significance of p53 gene alterations in node-negative breast cancer", 26, pp.225~235 (1993)
  22. "P53 determination alongside classical prognostic factors in node-negative breast cancer", 11, pp.393~397 (2000)

관련 논문AI추천

이 간행물의 다른 논문 (9건)