본문 바로가기
KERD
논문KCI 등재

Prognostic Significance of Abnormal -catenin Expression in BreastCarcinoma

Prognostic Significance of Abnormal -catenin Expression in Breast Carcinoma

이원애
대한병리학회|2005.04|Journal of Pathology and Translational Medicine|제39권 제2호|pp. 114-119

2

조회

0

다운로드

0

인용

0

참고문헌

주제분류병리학

초록

Abstract

Background : The subcellular localization and activity of β-catenin are tightly regulated within the cell. The aim of this study was to analyze the aberrant β-catenin expression in breast carcinomas and to determine its clinical significance. Methods : Fifty five cases of breast carcinoma were immunostained with monoclonal antibodies against β-catenin. Normal expression of β-catenin was defined as exclusive membranous staining. Abnormal expression of β-catenin was reclassified into 3 categories: complete or partial loss of membranous staining (LOM) without cytoplasmic staining and nuclear staining, LOM with cytoplasmic staining and without nuclear staining, and LOM with nuclear staining and with/without cytoplasmic staining. Results : Normal membranous β-catenin expression was detected in 25 (45.5%) of 55 cases of breast carcinoma. Thirty cases with abnormal β-catenin expression comprised 9 cases (16.1%) showing LOM without cytoplasmic and/or nuclear staining, 20 cases (36.4%) showing LOM with cytoplasmic staining and without nuclear staining, and one case (1.8%) showing LOM with nuclear and cytoplasmic staining. Abnormal β-catenin expression was significantly correlated with lymph node metastasis (p=0.03). LOM with cytoplasmic and/or nuclear expression was significantly correlated with poor disease free survival by univariate (p=0.03) and multivariate analyses (p=0.03). In addition, it was correlated with poor overall survival with a borderline significance (p=0.059). Conclusions : This study suggests that the cytoplasmic and/or nuclear expression of β-catenin can be used as a biologic marker for predicting disease recurrence and poor patients' survival in breast carcinomas.

참고문헌 (23)

  1. "Oncogenic pathwaysin hereditary and sporadic breast cancer", 49, pp.34~43 (2004)
  2. "Functional correlation between cell adhesive proportionsand some cell surface proteins", 75, pp.464~74 (1977)
  3. "Cadherin cell adhesion receptors as a morphogeneticregulator", 251, pp.1451~5 (1991)
  4. "Wnt family proteins in mammary developmentand cancer", 9, pp.119~31 (2004)
  5. "Beta-catenin and Tcfsin mammary development and cancer", 8, pp.145~58
  6. "Wnt signaling and mammary tumorigenesis", 6, pp.37~52 (2001)
  7. "Constitutive transcriptional activationby a beta-catenin-Tcf complex in APC-", -colon carcinoma, 1997, pp.275, 1784~7
  8. "Regulationof intercellular beta-catenin levels by adenomatous polyposis coli(APC)tumor-suppressor protein", 92, pp.3046~50 (1995)
  9. "Mutational analysisof the APC", beta-catenin, pp.1998, 58[DOI]
  10. "Prognostic significance of E-cadherinand beta-catenin in resected stage I non-small cell lung cancer", 24, pp.441~9 (2003)
  11. "Increased beta-catenin mRNAlevels and mutational alterations of the APC and beta-catenin geneare present in intestinal-type gastric cancer", 23, pp.87~91 (2002)
  12. "Mutation and altered expression ofbeta-catenin during gallbladder carcinogenesis", 26, pp.758~66
  13. "beta-catenin nuclear localizationis associated with grade in ovarian serous carcinoma", 88, pp.363~8 (2003)
  14. "Histological grading of breastcarcinomas:a study of interobserver agreement", 26, pp.873~9 (1995)
  15. "Beta-catenin,a novel prognostic markerfor breast cancer:its roles in cyclin D1 expression and cancer progression", 97, pp.4262~6 (2000)
  16. "Pin1 regulates turnoverand subcellular localization of beta-catenin by inhibiting itsinteraction with APC", 3, pp.793~801 (2001)
  17. "Gene expression profiling of breastcancers with emphasis of beta-catenin regulation", 19, pp.275~82
  18. "Wnt signaling and breast cancer", 3, pp.36~41 (2004)
  19. "Beta-catenin and p53 analysesof a breast carcinoma tissue microarray", 100, pp.2084~92 (2004)
  20. "Deregulatedbeta-catenin induces a p53- and ARF-dependent growth arrestand cooperates with Ras in transformation", 20, pp.4912~22 (2001)
  21. "Deficiency of p53 acceleratesmammary tumorigenesis in Wnt-1 transgenic mice and promoteschromosomal instability", 9, pp.882~95 (1995)
  22. "Siah-1,SIP,and Ebi collaborate in a novelpathway for beta-catenin degradation linked to p53 responses", 7, pp.915~26 (2001)
  23. "Siah-1 mediates a novel beta-catenindegradation pathway linking p53 to the adenomatous polyposis coliprotein", 7, pp.927~36 (2001)

관련 논문AI추천

E-cadherin Expression Loss in T1 Invasive Ductal Carcinoma of theBreast as a Predictive Marker for Lymph Node Metastasis김은경, Aysegul Sahin대한병리학회 · Journal of Pathology and Translational Medicine2005 · 제39권 제3호Prognostic Significance of Immunohistochemical Expression of p53 Gene Product in Operable Breast CancerHong Suk Song, Ki Yong Jeong, Sun Hee Kang, Young Rok Do, Yu Sa Kim대한암학회 · Cancer Research and Treatment2006 · 제38권 제4호A Clinical Analysis of PTEN Expressions in Breast CancersChang Hyeok Ahn, Hang Ju Cho, Jeong Soo Kim, Kee Hwan Kim, Keun Woo Lim, Sang Seol Jung, Se Jeong Oh, Seock Ah Im, Woo Chan Park대한암학회 · Cancer Research and Treatment2003 · 제35권 제2호Immunohistochemical Study of β-catenin Expression between Hepatocellular Carcinoma and CholangiocarcinomaKi Jung Yun, Suck Chei Choi, Tae Hyeon Kim, Weon Cheol Han대한암학회 · Cancer Research and Treatment2002 · 제34권 제2호The Immunoexpressions and Prognostic Significance of Inhibin Alpha and Beta Human Chorionic Gonadotrophins (hCG) in Breast CarcinomasChangsuk Kang, Eundeok Chang, Eunjung Lee, Jeong Soo Kim, Se Jeong Oh대한암학회 · Cancer Research and Treatment2005 · 제37권 제4호Clinical Value of Cyclooxygenase-2 Expression in Human Breast CarcinomaGyung-Yub Gong, Jin-Hee Ahn, Jung-Shin Lee, Myung-Ju Ahn, Sei-Hyun Ahn, Sung-Bae Kim, Woo Kun Kim, Yoon-Koo Kang대한암학회 · Cancer Research and Treatment2004 · 제36권 제3호

이 간행물의 다른 논문 (12건)

S Phase Kinase Associated Protein 2 Expression in Breast Cancer andIts Prognostic Implications오세정, 강창석, 장은덕, 이은정pp. 69-73비소세포 폐암종에서 bcl-2, p53, VEGF의 발현: 미세혈관밀도 및 예후와의 상관관계최현주, 강석진, 유진영, 정지한, 강창석pp. 74-80임신 후기 어미 쥐에 투여한 덱사메타손이 신생 쥐의 중추신경계 성숙에 미치는 영향김종일, 구혜수, 윤수정pp. 81-90Expression of p63, bcl-2, bcl-6 and p16 in Basal Cell Carcinoma andSquamous Cell Carcinoma of the Skin정진룡, 장향란, 김애리, 김인선, 계영철pp. 91-98Expression of Vascular Endothelial Growth Factors A, C and D in GastricAdenocarcinoma이진욱, 양두현, 장규윤, 문우성, 유기훈, 이동근, 정명자, 강명재pp. 99-105
원문 보기