Clinicopathological Features of Low-Grade Thyroid-like Nasopharyngeal Papillary Adenocarcinoma
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Purpose Primary low-grade thyroid-like papillary adenocarcinomas are extremely rare neoplasms that generally originate in the nasopharynx. Here, we describe a novel case of a 15-year-old Chinese girl who was diagnosed with low-grade thyroid-like papillary adenocarcinoma, including a brief review of the literature to reveal the clinicopathological features of lowgrade thyroid-like nasopharyngeal papillary adenocarcinoma. Materials and Methods Immunohistochemistry was used to evaluate the expression of pan-cytokeratin (CKpan), cytokeratin (CK) 7, thyroid transcription factor 1 (TTF-1), vimentin, epithelial membrane antigen (EMA), thyroglobulin, CD15, S100, P40, CK20, CDX-2, glial fibrillary acidic protein (GFAP), and Ki-67. Additionally, in situ hybridization investigation was utilized to identify the presence of small Epstein-Barr virus (EBV)–encoded RNA. Results Histopathological analysis revealed florid proliferation of papillary structures lined by columnar epithelial cells with fibrovascular cores. Immunohistochemically, the neoplastic cells were positive for CKpan, CK7, TTF-1, vimentin, and EMA, but negative for thyroglobulin, CD15, S100, P40, CK20, CDX-2, and GFAP. The Ki-67–labeling index reached 5% in the most concentrated spot. In situ hybridization for EBV was negative. Conclusion Due to the distinct rarity of low-grade thyroid-like papillary adenocarcinomas with a favorable clinical outcome, a nationwide effort to raise public awareness of this neoplasm is required.
Abstract
Purpose Primary low-grade thyroid-like papillary adenocarcinomas are extremely rare neoplasms that generally originate in the nasopharynx. Here, we describe a novel case of a 15-year-old Chinese girl who was diagnosed with low-grade thyroid-like papillary adenocarcinoma, including a brief review of the literature to reveal the clinicopathological features of lowgrade thyroid-like nasopharyngeal papillary adenocarcinoma. Materials and Methods Immunohistochemistry was used to evaluate the expression of pan-cytokeratin (CKpan), cytokeratin (CK) 7, thyroid transcription factor 1 (TTF-1), vimentin, epithelial membrane antigen (EMA), thyroglobulin, CD15, S100, P40, CK20, CDX-2, glial fibrillary acidic protein (GFAP), and Ki-67. Additionally, in situ hybridization investigation was utilized to identify the presence of small Epstein-Barr virus (EBV)–encoded RNA. Results Histopathological analysis revealed florid proliferation of papillary structures lined by columnar epithelial cells with fibrovascular cores. Immunohistochemically, the neoplastic cells were positive for CKpan, CK7, TTF-1, vimentin, and EMA, but negative for thyroglobulin, CD15, S100, P40, CK20, CDX-2, and GFAP. The Ki-67–labeling index reached 5% in the most concentrated spot. In situ hybridization for EBV was negative. Conclusion Due to the distinct rarity of low-grade thyroid-like papillary adenocarcinomas with a favorable clinical outcome, a nationwide effort to raise public awareness of this neoplasm is required.
참고문헌 (27)
- He JH, "Clinicopathological characteristics of primary nasopharyngeal adenocarcinoma", Ai Zheng, 22, pp.753~757 (2003)
- McGuire LJ, "The histopathologic diagnosis of nasopharyngeal carcinoma", Ear Nose Throat J, 69, pp.229~236 (1990)
- Carrizo F, "Thyroid transcription factor-1 expression in thyroid-like nasopharyngeal papillary adenocarcinoma : report of 2 cases", Ann Diagn Pathol, 9, pp.189~192 (2005)
- Wu PY, "Adult thyroidlike low-grade nasopharyngeal papillary adenocarcinoma with thyroid transcription factor-1 expression", Otolaryngol Head Neck Surg, 137, pp.837~838 (2007)
- Fu CH, "Primary thyroid-like papillary adenocarcinoma of the nasopharynx", Auris Nasus Larynx, 35, pp.579~582 (2008)
- Bansal A, "An unusual case of low-grade tubulopapillary adenocarcinoma of the sinonasal tract", World J Surg Oncol, 6, pp.54~ (2008)
- Ohe C, "Thyroid-like low-grade nasopharyngeal papillary adenocarcinoma : report of two cases", Pathol Int, 60, pp.107~111 (2010)
- Sillings CN, "Thyroid-like papillary adenocarcinoma of the nasopharynx: a case report in a 19-year-old male", Oral Surg Oral Med Oral Pathol Oral Radiol Endod, 110(3), pp.e25~e28 (2010)
- Petersson F, "Biphasic low-grade nasopharyngeal papillary adenocarcinoma with a prominent spindle cell component : report of a case localized to the posterior nasal septum", Head Neck Pathol, 5, pp.306~313 (2011)
- Huang CH, "Positive immunostaining of thyroid transcription factor-1 in primary nasopharyngeal papillary adenocarcinoma", J Formos Med Assoc, 114, pp.473~474 (2015)
- Ozer S, "Thyroid-like papillary adenocarcinoma of the nasopharynx with focal thyroglobulin expression", Pathology, 45, pp.622~624 (2013)
- Oishi N, "Thyroid-like low-grade nasopharyngeal papillary adenocarcinoma : case report and literature review", Pathol Res Pract, 210, pp.1142~1145 (2014)
- Ozturk K, "Primary thyroid-like papillary adenocarcinoma of the nasal septum: a case report", Ear Nose Throat J, 94, pp.E19~E21 (2015)
- Wu R, "Clinicopathological features of low-grade nasopharyngeal papillary adenocarcinoma", Zhonghua Bing Li Xue Za Zhi, 43, pp.613~617 (2014)
- Zhang X, "Low-grade thyroid-like papillary of the nasopharynx with squamous differentiation : report of a case", Lin Chuang Yu Shi Yan Bing Li Xue Za Zhi, 31, pp.1199~1200 (2015)
- Kang Z, "Low-grade nasopharyngeal papillary adenocarcinoma : report of two cases and literature review", Lin Chuang Yu Shi Yan Bing Li Xue Za Zhi, 31, pp.1165~1167 (2015)
- Li JF, "Thyroid-like low-grade nasopharyngeal papillary adenocarcinoma : report of a case", Zhonghua Bing Li Xue Za Zhi, 40, pp.638~639 (2011)
- Han S, "Clinicopathological observation of 1 cases of low grade nasopharyngeal papillary adenocarcinoma", Lin Chuang Yu Shi Yan Bing Li Xue Za Zhi, 29, pp.328~330 (2013)
- Chen Z, "Thyroid-like low-grade nasopharyngeal papillary adenocarcinoma : one case report", Lin Chung Er Bi Yan Hou Tou Jing Wai Ke Za Zhi, 28, pp.1266~1267 (2014)
- Wenig BM, "Nasopharyngeal papillary adenocarcinoma : a clinicopathologic study of a lowgrade carcinoma", Am J Surg Pathol, 12, pp.946~953 (1988)
- Thompson L, "World Health Organization classification of tumours : pathology and genetics of head and neck tumours", Ear Nose Throat J, 85, pp.74~ (2006)
- Bingle CD, "Thyroid transcription factor-1", Int J Biochem Cell Biol, 29, pp.1471~1473 (1997)
- Katoh R, "Thyroid transcription factor-1 in normal, hyperplastic, and neoplastic follicular thyroid cells examined by immunohistochemistry and nonradioactive in situ hybridization", Mod Pathol, 13, pp.570~576 (2000)
- Ordonez NG, "Value of thyroid transcription factor-1immunostaining in tumor diagnosis : a review and update", Appl Immunohistochem Mol Morphol, 20, pp.429~444 (2012)
- Imamura Y, "CD15(C3D-1)immunoreactivity in normal, benign and malignant thyroid lesions", Appl Immunohistochem, 6, pp.181~186 (1998)
- Ortiz-Rey JA, "Expression of CDX2, cytokeratins 7 and 20 in sinonasal intestinal-type adenocarcinoma", Appl Immunohistochem Mol Morphol, 13, pp.142~146 (2005)
- Wang CP, "Photodynamic therapy with topical 5-aminolevulinic acid as a postoperative adjuvant therapy for an incompletely resected primary nasopharyngeal papillary adenocarcinoma : a case report", Lasers Surg Med, 38, pp.435~438 (2006)