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Polymorphous Low-Grade Adenocarcinoma in the Nasopharynx: A Case Report and Review of the Literature

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주제분류이비인후과학

초록

Polymorphous low-grade adenocarcinoma (PLGA) is a neoplasm that usually occurs in theminor salivary glands located in the mucosa of the soft and hard palates, the buccal mucosa,and the upper lip. It rarely occurs in the nasopharynx, and only six cases have been reported. PLGA can be treated by wide local excision and requires no additional treatment if a negativemargin is identified in frozen biopsy. Here we describe a case of PLGA originating in the nasopharyngealmucosa. We were able to completely resect the tumor using simple endoscopicsurgery rather than using an open approach, such as a transpalatal resection. Our patient hadno local recurrence or distant metastasis at the 24-month follow-up.

Abstract

Polymorphous low-grade adenocarcinoma (PLGA) is a neoplasm that usually occurs in theminor salivary glands located in the mucosa of the soft and hard palates, the buccal mucosa,and the upper lip. It rarely occurs in the nasopharynx, and only six cases have been reported. PLGA can be treated by wide local excision and requires no additional treatment if a negativemargin is identified in frozen biopsy. Here we describe a case of PLGA originating in the nasopharyngealmucosa. We were able to completely resect the tumor using simple endoscopicsurgery rather than using an open approach, such as a transpalatal resection. Our patient hadno local recurrence or distant metastasis at the 24-month follow-up.

참고문헌 (11)

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  5. Wenig BM, "Polymorphous low-grade adenocarcinoma of seromucous glands of the nasopharynx. A report of a case and a discussion of the morphologic and immunohistochemical features", Am J Clin Pathol, 92(1), pp.104~109 (1989)
  6. Yu Shih Lai, "Exclusively Endoscopic Resection of Nasopharyngeal Adenocarcinoma", Clinical and Experimental Otorhinolaryngology, 6(4), pp.263~265 (2013), 대한이비인후과학회[DOI]
  7. Lengyel E, "Polymorphous low-grade adenocarcinoma of the nasopharynx. Case report and review of the literature", Strahlenther Onkol, 176(1), pp.40~42 (2000)
  8. Wei YC, "Polymorphous low-grade adenocarcinoma of the nasopharynx : A case report and brief review", J Clin Pathol, 61(10), pp.1124~1126 (2008)
  9. Garzaro M, "Nasopharyngeal polymorphous low-grade adenocarcinoma in a patient with nonfunctioning pituitary macroadenoma", B-ENT, 6(1), pp.59~62 (2010)
  10. Kaul R, "Polymorphous low grade adenocarcinoma-an unusual presentation", Online J Health Allied Scs, 9(2), pp.18~ (2010)
  11. Martínez-Capoccioni G, "Transnasal endoscopic resection of a nasopharyngeal pleomorphic adenoma : A rare case report", Eur Arch Otorhinolaryngol, 269(8), pp.2009~2013 (2012)

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