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Calcium Phosphate Glass가 마우스 두개골 세포에 미치는 영향

The Effects of Calcium Phosphate Glass on Mouse Calvarial Cell

김민경|이덕연|김종관|이용근|조규성|최성호|김창성|채중규
대한치주과학회 (The Korean Academy Of Periodontology)|2004.03|Journal of Periodontal & Implant Science|제34권 제1호|pp. 49-59

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참고문헌

주제분류치의학

초록

Abstract

The goal of periodontal treatment is not only to arrest the progression of the disease but also to promote the functional, esthetic regeneration of the periodontium. Flap operation, bone graft, guided tissue regeneration, growth factors and bone morphogenetic protein have been used for this purpose. Among these techniques of regeneration, alloplastic graft, especially calcium phosphate is getting more attention recently. The purpose of this study was to evaluate the effects of calcium phosphate glass on mouse calvarial cell in vitro. The toxicity of calcium phosphate glass was measured using MTT assay, the synthesis of collagen was measured using collagen assay, and ALP activity was measured. The experimental groups were cultured with calcium phosphate glass(both AQ-, and HT-CPG) in concentration of 0.01, 0.02, 0.1, 0.2g/ml. The results are as follows 1. In concentrations not exceeding 0.02g/ml, both the groups(AQ-CPG, HT-CPG) didn't show any toxicity on mouse calvarial cell(p<0.05). 2. In both the experimental groups are the concentration of 0.02g/ml, collagen expressions were significantly up-regulated (p<0.05). 3. In both the experimental groups are the concentration of 0.02g/ml, ALP activity was not significantly up-regulated, but ALP activity in both experimental groups were greater than control group(p<0.05). The results suggested that the use of calcium phosphate glass may promotes periodontal regeneration. Ongoing studies are necessary in order to determine their regeneration effects.

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관련 논문AI추천

새롭게 개발된 비정질의 Calcium Phosphate가 백서두개골의 골재생에 미치는 영향김종관, 김창성, 이용근, 조규성, 채경준, 채중규, 최성호, 최정유대한치주과학회 · Journal of Periodontal & Implant Science2007 · 제37권 제4호미세다공성 Biphasic calcium phosphate ceramics의 골이식 대체재로서의 기본특성에 대한 비교연구박광범, 박진우, 서조영, 안현욱, 양동준, 여신일, 장일성, 최석규대한치주과학회 · Journal of Periodontal & Implant Science2006 · 제36권 제4호생분해성 Calcium Metaphosphate 골이식재의 골조직재생효과에 관한 연구구영, 김석영, 류인철, 양승민, 이용무, 정종평, 채한승, 천성수, 최상묵, 한수부대한치주과학회 · Journal of Periodontal & Implant Science2003 · 제33권 제1호골이식재로서의 Calcium Polyphosphate 평가 : 동물 연구계승범, 김석영, 류인철, 양승민, 이승진, 이용무, 이인경, 임윤탁, 정종평, 한수부대한치주과학회 · Journal of Periodontal & Implant Science2003 · 제33권 제2호뼈모세포 초기부착에 영향을 미치는 나노수준 거칠기 칼슐포스페이트 박막 개발#고재승, Guang Zhi Dong, Hyun-Man Kim대한구강해부학회 · 대한구강해부학회지2005 · 제29권 제1호백서 두개골 결손부에서 Ca-P 피복된 이종골의 골재생 효과김영준, 김옥수, 박홍주, 성선주, 정현주대한치주과학회 · Journal of Periodontal & Implant Science2004 · 제34권 제3호

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