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치주질환과 관상동맥질환의 관련성에 대한 임상적 연구

Association between periodontal disease and coronary heart disease

정현주|김주한|이준호
대한치주과학회 (The Korean Academy Of Periodontology)|2005.03|Journal of Periodontal & Implant Science|제35권 제1호|pp. 111-122

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참고문헌

키워드

acute myocardial infarctionperiodontal diseasecoronary heart disease
주제분류치의학

초록

Coronary heart disease is the leading cause of mortality in adult population. Whereas the association between periodontal disease and coronary heart disease (CHD) are controversial, recent studies reported the association between periodontal disease and acute myocardial infarction or prognosis of CHD. This study was aimed to investigate the relationship between periodontal disease and angiographically defined CHD, and acute myocardial infarction, and the prognosis of treated CHD. Patients under the age of 60 who had undergone the diagnostic coronary angiography were enrolled in this study. Subjects were classified as positive CHD (+CHD, n=37) with coronary artery stenosis more than 50% in at least one of major epicardial arteries, and negative CHD (-CHD, n=20) without stenosis. After recording the number of missing teeth, periodontal disease status was measured by means of plaque index (PI), gingival index (GI), bleeding on probing (BOP), probing depth (PD), and clinical attachment level (CAL). Positive CHD subjects were classified into acute myocardial infarction group (AMI), and non-AMI with angina pectoris and old myocardial infarction. Six months postoperatively, positive CHD subjects were followed and had undergone the coronary angiography again. Even though there was no significant difference in the periodontal parameters and status between positive CHD and negative CHD, some periodontal parameters, such as mean probing depth and proportion of sites with probing depth greater than 4mm or 6mm were significantly different between AMI and Non-AMI(p<0.05). There was no significant difference in the periodontal parameters according to in angiographically follow-up status. These results indicate that periodontal disease may be associated with the occurrence of acute myocardial infarction.

Abstract

Coronary heart disease is the leading cause of mortality in adult population. Whereas the association between periodontal disease and coronary heart disease (CHD) are controversial, recent studies reported the association between periodontal disease and acute myocardial infarction or prognosis of CHD. This study was aimed to investigate the relationship between periodontal disease and angiographically defined CHD, and acute myocardial infarction, and the prognosis of treated CHD. Patients under the age of 60 who had undergone the diagnostic coronary angiography were enrolled in this study. Subjects were classified as positive CHD (+CHD, n=37) with coronary artery stenosis more than 50% in at least one of major epicardial arteries, and negative CHD (-CHD, n=20) without stenosis. After recording the number of missing teeth, periodontal disease status was measured by means of plaque index (PI), gingival index (GI), bleeding on probing (BOP), probing depth (PD), and clinical attachment level (CAL). Positive CHD subjects were classified into acute myocardial infarction group (AMI), and non-AMI with angina pectoris and old myocardial infarction. Six months postoperatively, positive CHD subjects were followed and had undergone the coronary angiography again. Even though there was no significant difference in the periodontal parameters and status between positive CHD and negative CHD, some periodontal parameters, such as mean probing depth and proportion of sites with probing depth greater than 4mm or 6mm were significantly different between AMI and Non-AMI(p<0.05). There was no significant difference in the periodontal parameters according to in angiographically follow-up status. These results indicate that periodontal disease may be associated with the occurrence of acute myocardial infarction.

참고문헌 (28)

  1. "Periodontal disease and cardiovascular disease", 67, pp.1123~1137 (1996)
  2. "Plaque and systemic disease:a reappraisal of the focal infection concept", 11, pp.209~220 (1984)
  3. "The pathobiology of periodontal diseases may affect systemic diseases:inversion of a paradigm", 3, pp.108~120 (1998)
  4. "Systemic diseases caused by oral infection", 13, pp.547~558 (2000)
  5. "Periodontal diseases contributions to cardiovascular disease:an overview of potential mechanisms", 3, pp.142~150 (1998)
  6. "Oral health and systemic disease:periodontitis and cardiovascular disease", 62, pp.859~870 (1998)
  7. "a risk factor for coronary heart disease", 3, pp.127~141 (1998)
  8. "Periodontitis - atherosclerosis syndrome:An expanded model of pathogenesis", 34, pp.346~352 (1999)
  9. "Dental disease and risk of coronary heart disease and mortality", 306, pp.688~691 (1993)
  10. "assessing the relationship between dental disease and coronary heart disease in elderly US veterans", 129, pp.301~311 (1998)
  11. "Investigation of the association between angiographically defined coronary artery disease and periodontal disease", 73, pp.1169~1176 (2002)
  12. "Examining the link between coronary heart disease and the elimination of chronic dental infections", 132, pp.883~889 (2001)
  13. "Pre-existing cardiovascular disease and periodontitis:a follow-up study", 81, pp.186~191 (2002)
  14. "Association between dental health and acute myocardial infarction", 298, pp.779~781 (1989)
  15. "Association between periodontal disease and acute myocardial infarction", 71, pp.1882~1886 (2000)
  16. "Dental infection and the risk of new coronary events:prospective study of patients with documented coronary artery disease", 20, pp.588~592 (1995)
  17. "Poor oral health and coronary heart disease", 9, pp.1631~1636 (1996)
  18. "Mechanism by which periodontitis may contribute to atherosclerosis", 32, pp.837~846 (2002)
  19. "한국인에서 치주질환과 관상동맥질환의 관련성에 대한 염증표지자와 IL-1 유전자 다변성의 영향.대한치주과학회지", 34, pp.607~622 (2004)
  20. "Periodontal assessment of patients undergoing angioplasty for treatment of coronary artery disease", 73, pp.631~636 (2002)
  21. "Myocardial infarction and periodontal disease", 77, pp.990~ (1998)
  22. "Cigarette smoking increases the risk for subgingival infection with periodontal pathogens", 67, pp.1050~1054 (1996)
  23. "The filter cigarette and coronary heart disease:the framingham story", 2, pp.109~113 (1981)
  24. "Diabetes mellitus:subclinical cardiovascular disease and the risk of incident cardiovascular disease and all-cause mortality", 20, pp.823~829 (2000)
  25. "Response to periodontal therapy in diabetics and smokers", 67, pp.1094~1102 (1996)
  26. "Association between smoking different tobacco products and periodontal indexes", 54, pp.481~487 (1983)
  27. "Flurbiprofen:A potent inhibitor of alveolar bone resorption in beagles", 227, pp.640~642 (1985)
  28. "Flurbiprofen:A potent inhibitor of alveolar bone resorption in beagles", 227, pp.640~642 (1985)

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