한국 성인의 치주질환과 고감도 C-반응단백질 농도의 상관관계
Relationship between periodontal disease and level of high-sensitivity C reactive protein in Korean adults
2
조회
0
다운로드
1
인용
0
참고문헌
키워드
초록
Objectives: The purpose of this study was to comprehensively examine the relationship between periodontal disease and high-sensitivity C reactive protein (hs-CRP) level. Methods: This study was conducted using the data from the sixth Korea National Health and Nutrition Examination Survey. SPSS 18.0 for Windows was used for statistical analysis. The data were collected from 4,576 subjects aged ≥19 years. To analyze the association between periodontal disease and hs-CRP level, chi-squared test and logistic regression analysis were used. Results: Consequent to correcting all the disturbance variables, the moderate risk of hs-CRP was 1.39 times higher in patients with periodontal disease than in those without (OR=1.39; 95% CI:1.14- 1.69), whereas the high risk of hs-CRP was 1.10 times but there was no statistical significance (OR=1.10; 95% CI:0.79-1.53). Conclusions: Periodontal disease contributes to raising the risk of systemic inflammation and hs-CRP from low to moderate. Periodontal disease is associated with an early rise in hs-CRP.
Abstract
Objectives: The purpose of this study was to comprehensively examine the relationship between periodontal disease and high-sensitivity C reactive protein (hs-CRP) level. Methods: This study was conducted using the data from the sixth Korea National Health and Nutrition Examination Survey. SPSS 18.0 for Windows was used for statistical analysis. The data were collected from 4,576 subjects aged ≥19 years. To analyze the association between periodontal disease and hs-CRP level, chi-squared test and logistic regression analysis were used. Results: Consequent to correcting all the disturbance variables, the moderate risk of hs-CRP was 1.39 times higher in patients with periodontal disease than in those without (OR=1.39; 95% CI:1.14- 1.69), whereas the high risk of hs-CRP was 1.10 times but there was no statistical significance (OR=1.10; 95% CI:0.79-1.53). Conclusions: Periodontal disease contributes to raising the risk of systemic inflammation and hs-CRP from low to moderate. Periodontal disease is associated with an early rise in hs-CRP.
참고문헌 (26)
- Paul M. Ridker, "Connecting the role of C-reactive protein and statins in cardiovascular disease", Clinical Cardiology, 26(S3), pp.39~44 (2003), Wiley[DOI]
- Elizabeth B. Windgassen, "C-Reactive Protein and High-Sensitivity C-Reactive Protein: An Update for Clinicians", Postgraduate Medicine, 123(1), pp.114~119 (2015), Informa UK Limited[DOI]
- Thomas A. Pearson, "Markers of Inflammation and Cardiovascular Disease", Circulation, 107(3), pp.499~511 (2003), Ovid Technologies (Wolters Kluwer Health)[DOI]
- Carlos Martín Ardila, "Comparison of serum amyloid A protein and C-reactive protein levels as inflammatory markers in periodontitis", Journal of Periodontal & Implant Science, 45(1), pp.14~22 (2015), 대한치주과학회
- Sandra N. Verhagen, "C-reactive protein and incident diabetes in patients with arterial disease", European Journal of Clinical Investigation, 43(10), pp.1052~1059 (2013), Wiley[DOI]
- Hui-Hui Liu, "High-sensitivity C-reactive protein and hypertension: combined effects on coronary severity and cardiovascular outcomes", Hypertension Research, 42(11), pp.1783~1793 (2019), Springer Science and Business Media LLC[DOI]
- Dong-Hun Han, "Group of Serum Inflammatory Markers and Periodontitis–Metabolic Syndrome Coexistence in Koreans", Journal of Periodontology, 83(5), pp.612~620 (2012), Wiley[DOI]
- MarceloCarlos Bortoluzzi, "Tooth loss, chewing ability and quality of life", Contemporary Clinical Dentistry, 3(4), pp.393~397 (2012), Medknow[DOI]
- 이지영, "치주질환자의 구강보건특성과 삶의 질의 관계", 한국치위생학회지, 13(5), pp.835~843 (2013), 한국치위생학회[DOI]
- Kejin Liu, "Prevalence and Risk Factors of CKD in Chinese Patients with Periodontal Disease", PLoS ONE, 8(8), pp.e70767~ (2013), Public Library of Science (PLoS)[DOI]
- J. F. Macedo, "Periodontal disease and oral health-related behavior as factors associated with preterm birth: a case-control study in south-eastern Brazil", Journal of Periodontal Research, 49(4), pp.458~464 (2014), Wiley[DOI]
- Zuhair S. Natto, "Methodological Quality Assessment of Meta-analyses and Systematic Reviews of the Relationship Between Periodontal and Systemic Diseases", Journal of Evidence Based Dental Practice, 19(2), pp.131~139 (2019), Elsevier BV[DOI]
- Fabrizio Sgolastra, "Effectiveness of Periodontal Treatment to Improve Metabolic Control in Patients With Chronic Periodontitis and Type 2 Diabetes: A Meta-Analysis of Randomized Clinical Trials", Journal of Periodontology, 84(7), pp.958~973 (2013), Wiley[DOI]
- Peter B. Lockhart, "Periodontal Disease and Atherosclerotic Vascular Disease: Does the Evidence Support an Independent Association?", Circulation, 125(20), pp.2520~2544 (2012), Ovid Technologies (Wolters Kluwer Health)[DOI]
- Rodrigo Martin-Cabezas, "Association between periodontitis and arterial hypertension: A systematic review and meta-analysis", American Heart Journal, 180, pp.98~112 (2016), Elsevier BV[DOI]
- N. Pischon, "Obesity, Inflammation, and Periodontal Disease", Journal of Dental Research, 86(5), pp.400~409 (2016), SAGE Publications[DOI]
- Jean Suvan, "Association between overweight", obesity and periodontitis in adults. A systematic review, 2011, pp.12(5), e381~e404[DOI]
- Korea national health and nutrition examination survey 6th(2013-2015), "Korean Ministry of Health and Welfare", Korea Centers for Disease Control and Prevention, 3~ (2015)
- Korea national health and nutrition examination survey 7th(2016-2017), "Korean Ministry of Health and Welfare", Korea Centers for Disease Control and Prevention, 9~ (2019)
- 정정옥, "한국 성인의 흡연과 치주질환과의 관련성 : 2010년 국민건강 영양조사 자료", 한국치위생학회지, 13(3), pp.481~489 (2013), 한국치위생학회[DOI]
- 이은선, "치주질환과 만성신장질환의 연관성: 코호트 연구에 대한 체계적 고찰", 치위생과학회지, 17(2), pp.160~167 (2017), 한국치위생과학회[DOI]
- Paul M. Ridker, "C-Reactive Protein and Other Markers of Inflammation in the Prediction of Cardiovascular Disease in Women", New England Journal of Medicine, 342(12), pp.836~843 (2000), Massachusetts Medical Society[DOI]
- Li Pan, "The association between high-sensitivity C-reactive protein and blood pressure in Yi people", BMC Public Health, 19(1), pp.991~ (2019), Springer Science and Business Media LLC[DOI]
- 이정환, "C-reactive Protein Detection in Gingival Crevicular Fluid as an Acute Systemic Inflammation Biomarker in Patients with Severe Periodontitis", 대한치과재료학회지, 40(4), pp.321~326 (2013), 대한치과재료학회
- Barbara Noack, "Periodontal Infections Contribute to Elevated Systemic C-Reactive Protein Level", Journal of Periodontology, 72(9), pp.1221~1227 (2001), Wiley[DOI]
- Spiros Paraskevas, "A systematic review and meta-analyses on C-reactive protein in relation to periodontitis", Journal of Clinical Periodontology, 35(4), pp.277~290 (2008), Wiley[DOI]