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Vaccines against periodontitis: a forward-looking review

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Periodontal disease, as a polymicrobial disease, is globally endemic as well as being a global epidemic. It is the leading cause for tooth loss in the adult population and has been positively related to life-threatening systemic diseases such as atherosclerosis and diabetes. As a result, it is clear that more sophisticated therapeutic modalities need to be developed, which may include vaccines. Up to now, however, no periodontal vaccine trial has been successful in satisfying all the requirements; to prevent the colonization of a multiple pathogenic biofilm in the subgingival area, to elicit a high level of effector molecules such as immunoglobulin sufficient to opsonize and phagocytose the invading organisms, to suppress the induced alveolar bone loss, or to stimulate helper T-cell polarization that exerts cytokine functions optimal for protection against bacteria and tissue destruction. This article reviews all the vaccine trials so as to construct a more sophisticated strategy which may be relevant in the future. As an innovative strategy to circumvent these barriers, vaccine trials to stimulate antigen-specific T-cells polarized toward helper T-cells with a regulatory phenotype (Tregs, CD4+, CD25+, FoxP3+) have also been introduced. Targeting not only a single pathogen, but polymicrobial organisms, and targeting not only periodontal disease, but also periodontal diseasetriggered systemic disease could be a feasible goal.

Abstract

Periodontal disease, as a polymicrobial disease, is globally endemic as well as being a global epidemic. It is the leading cause for tooth loss in the adult population and has been positively related to life-threatening systemic diseases such as atherosclerosis and diabetes. As a result, it is clear that more sophisticated therapeutic modalities need to be developed, which may include vaccines. Up to now, however, no periodontal vaccine trial has been successful in satisfying all the requirements; to prevent the colonization of a multiple pathogenic biofilm in the subgingival area, to elicit a high level of effector molecules such as immunoglobulin sufficient to opsonize and phagocytose the invading organisms, to suppress the induced alveolar bone loss, or to stimulate helper T-cell polarization that exerts cytokine functions optimal for protection against bacteria and tissue destruction. This article reviews all the vaccine trials so as to construct a more sophisticated strategy which may be relevant in the future. As an innovative strategy to circumvent these barriers, vaccine trials to stimulate antigen-specific T-cells polarized toward helper T-cells with a regulatory phenotype (Tregs, CD4+, CD25+, FoxP3+) have also been introduced. Targeting not only a single pathogen, but polymicrobial organisms, and targeting not only periodontal disease, but also periodontal diseasetriggered systemic disease could be a feasible goal.

참고문헌 (83)

  1. Socransky SS, "Microbial complexes in subgingival plaque", J Clin Periodontol, 25, pp.134~144 (1998)
  2. Slots J, "Systemic antibiotics in periodontics", J Periodontol, 75, pp.1553~1565 (2004)
  3. Parra B, "Detection of human viruses in periodontal pockets using polymerase chain reaction", Oral Microbiol Immunol, 11, pp.289~293 (1996)
  4. Contreras A, "Relationship between herpesviruses and adult periodontitis and periodontopathic bacteria", J Periodontol, 70, pp.478~784 (1999)
  5. Kubar A, "Real-time PCR quantification of cytomegalovirus in aggressive periodontitis lesions using TaqMan technology", J Periodontal Res, 39, pp.81~86 (2004)
  6. Ling LJ, "Association between human herpesviruses and the severity of periodontitis", J Periodontol, 75, pp.1479~1485 (2004)
  7. Dzink JL, "The predominant cultivable microbiota of active and inactive lesions of destructive periodontal diseases", J Clin Periodontol, 15, pp.316~323 (1988)
  8. Sundqvist G, "Pathogenicity and virulence of black-pigmented gram-negative anaerobes", FEMS Immunol Med Microbiol, 6, pp.125~137 (1993)
  9. Persson GR, "Immunization against Porphyromonas gingivalis inhibits progression of experimental periodontitis in nonhuman primates", Infect Immun, 62, pp.1026~1031 (1994)
  10. Houston LS, "Function of anti-Porphyromonas gingivalis immunoglobulin classes in immunized Macaca fascicularis", Oral Microbiol Immunol, 14, pp.86~91 (1999)
  11. Page RC, "Vaccination and periodontitis: myth or reality", J Int Acad Periodontol, 2, pp.31~43 (2000)
  12. Gibson FC 3rd, "Porphyromonas gingivalis-specific immunoglobulin G prevents P. gingivalis-elicited oral bone loss in a murine model", Infect Immun, 72, pp.2408~2411 (2004)
  13. Travis J, "Porphyromonas gingivalis proteinases as virulence factors in the development of periodontitis", J Periodontal Res, 32, pp.120~125 (1997)
  14. Kadowaki T, "Purification and characterization of a novel argininespecific cysteine proteinase (argingipain) involved in the pathogenesis of periodontal disease from the culture supernatant of Porphyromonas gingivalis", J Biol Chem, 269, pp.21371~21378 (1994)
  15. Imamura T, "The role of gingipains in the pathogenesis of periodontal disease", J Periodontol, 74, pp.111~118 (2003)
  16. Moritz AJ, "Immunization with Porphyromonas gingivalis cysteine protease:effects on experimental gingivitis and ligature-induced periodontitis in Macaca fascicularis", J Periodontol, 69, pp.686~697 (1998)
  17. Gibson FC 3rd, "Prevention of Porphyromonas gingivalis-induced oral bone loss following immunization with gingipain R1", Infect Immun, 69, pp.7959~7963 (2001)
  18. Inagaki S, "Antibody responses of periodontitis patients to gingipains of Porphyromonas gingivalis", J Periodontol, 74, pp.1432~1439 (2003)
  19. Kuboniwa M, "Specific antibodies to Porphyromonas gingivalis Lysgingipain by DNA vaccination inhibit bacterial binding to hemoglobin and protect mice from infection", Infect Immun, 69, pp.2972~2979 (2001)
  20. Evans RT, "Immunization with Porphyromonas (Bacteroides) gingivalis fimbriae protects against periodontal destruction", Infect Immun, 60, pp.2926~2935 (1992)
  21. Fan Q, "Fimbriae of Porphyromonas gingivalis induce opsonic antibodies that significantly enhance phagocytosis and killing by human polymorphonuclear leukocytes", Oral Microbiol Immunol, 16, pp.144~152 (2001)
  22. Choi JI, "Capsular polysaccharide-fimbrial protein conjugate vaccine protects against Porphyromonas gingivalis infection in SCID mice reconstituted with human peripheral blood lymphocytes", Infect Immun, 66, pp.391~393 (1998)
  23. Gonzalez D, "Immunization with Porphyromonas gingivalis capsular polysaccharide prevents P. gingivalis-elicited oral bone loss in a murine model", Infect Immun, 71, pp.2283~2287 (2003)
  24. Takazoe I, "Colonization of the subgingival area by Bacteroides gingivalis", J Dent Res, 63, pp.422~426 (1984)
  25. Slots J, "Attachment of Bacteroides melaninogenicus subsp. asaccharolyticus to oral surfaces and its possible role in colonization of the mouth and of periodontal pockets", Infect Immun, 19, pp.254~264 (1978)
  26. Mouton C, "Immunochemical identification and preliminary characterization of a nonfimbrial hemagglutinating adhesin of Bacteroides gingivalis", Infect Immun, 57, pp.566~573 (1989)
  27. Maeba S, "Transcutaneous immunization with a 40-kDa outer membrane protein of Porphyromonas gingivalis induces specific antibodies which inhibit coaggregation by P. gingivalis", Vaccine, 23, pp.2513~2521 (2005)
  28. Saito S, "Inhibition of a Porphyromonas gingivalis colonizing factor between Actinomyces viscosus ATCC 19246 by monoclonal antibodies against recombinant 40-kDa outer-membrane protein", Gen Pharmacol, 28, pp.675~680 (1997)
  29. Abiko Y, "A human monoclonal antibody which inhibits the coaggregation activity of Porphyromonas gingivalis", Infect Immun, 65, pp.3966~3969 (1997)
  30. Ross BC, "Identification of vaccine candidate antigens from a genomic analysis of Porphyromonas gingivalis", Vaccine, 19, pp.4135~4142 (2001)
  31. Chu L, "Hemolytic activity in the periodontopathogen Porphyromonas gingivalis: kinetics of enzyme release and localization", Infect Immun, 59, pp.1932~1940 (1991)
  32. Okuda K, "Protective efficacy of active and passive immunizations against experimental infection with Bacteroides gingivalis in ligated hamsters", J Dent Res, 67, pp.807~811 (1988)
  33. Booth V, "Passive immunization with monoclonal antibodies against Porphyromonas gingivalis in patients with periodontitis", Infect Immun, 64, pp.422~427 (1996)
  34. Booth V, "Characterization of the Porphyromonas gingivalis antigen recognized by a monoclonal antibody which prevents colonization by the organism", J Periodontal Res, 32, pp.54~60 (1997)
  35. Shibata Y, "Construction of a functional single-chain variable fragment antibody against hemagglutinin from Porphyromonas gingivalis", Infect Immun, 66, pp.2207~2212 (1998)
  36. Hosogi Y, "Monoclonal antibody against Porphyromonas gingivalis hemagglutinin inhibits hemolytic activity", Eur J Oral Sci, 109, pp.109~113 (2001)
  37. Kaizuka K, "Human monoclonal antibody inhibits Porphyromonas gingivalis hemagglutinin activity", J Periodontol, 74, pp.38~43 (2003)
  38. Shibata Y, "Construction of novel human monoclonal antibodies neutralizing Porphyromonas gingivalis hemagglutination activity using transgenic mice expressing human Ig loci", Vaccine, 23, pp.3850~3856 (2005)
  39. Harano K, "An antiserum to a synthetic fimbrial peptide of Actinobacillus actinomycetemcomitans blocked adhesion of the microorganism", FEMS Microbiol Lett, 130, pp.279~285 (1995)
  40. Takamatsu-Matsushita N, "Immunogenicity of Actinobacillus actinomycetemcomitans serotype b-specific polysaccharide-protein conjugate", Oral Microbiol Immunol, 11, pp.220~225 (1996)
  41. Herminajeng E, "Protective humoral immunity induced by surfaceassociated material from Actinobacillus actinomycetemcomitans in mice", Microbes Infect, 3, pp.997~1003 (2001)
  42. Shao H, "Quorum sensing regulation of biofilm growth and gene expression by oral bacteria and periodontal pathogens", Periodontol 2000, 52, pp.53~67 (2010)
  43. Kuboniwa M, "Subgingival biofilm formation", Periodontol 2000, 52, pp.38~52 (2010)
  44. Lee J, "B-1 cell-derived monoclonal antibodies and costimulatory molecules", J Surg Res, 154, pp.293~298 (2009)
  45. 이지영, "항-Porphyromonas gingivalis heat shock protein 60 단클론항체의 생성과 특성 규명", The Journal of the Korean Academy of Periodontology (JPIS), 38(4), pp.565~578 (2008), 대한치주과학회
  46. Ha JA, "Monoclonal antibody to Porphyromonas gingivalis heat-shock protein (Abstract 2631)", 88th General Session & Exhibition of the IADR, pp.14~17 (2010), International Association for Dental Research
  47. Notkins AL, "Polyreactive antibodies and polyreactive antigen-binding B (PAB) Cells", Curr Top Microbiol Immunol, 252, pp.241~249 (2000)
  48. Gemmell E, "Modulation of the antibody response by Porphyromonas gingivalis and Fusobacterium nucleatum in a mouse model", Oral Microbiol Immunol, 19, pp.247~251 (2004)
  49. Choi JI, "Polarization of Porphyromonas gingivalis-specific helper T-cell subsets by prior immunization with Fusobacterium nucleatum", Oral Microbiol Immunol, 15, pp.181~187 (2000)
  50. Choi J, "Prior exposure of mice to Fusobacterium nucleatum modulates host response to Porphyromonas gingivalis", Oral Microbiol Immunol, 16, pp.338~344 (2001)
  51. Choi JI, "Fusobacterium nucleatum impairs serum binding to Porphyromonas gingivalis biofilm", Oral Microbiol Immunol, 18, pp.92~94 (2003)
  52. Sjostrom K, "Opsonic antibody activity against Actinobacillus actinomycetemcomitans in patients with rapidly progressive periodontitis", Infect Immun, 60, pp.4819~4825 (1992)
  53. Vasel D, "Shared antigens of Porphyromonas gingivalis and Bac teroides forsythus", Oral Microbiol Immunol, 11, pp.226~235 (1996)
  54. Seymour GJ, "Shouts and whispers: an introduction to immunoregulation in periodontal disease", Periodontol 2000, 35, pp.9~13 (2004)
  55. Sasaki H, "The interleukin-10 knockout mouse is highly susceptible to Porphyromonas gingivalis-induced alveolar bone loss", J Periodontal Res, 39, pp.432~441 (2004)
  56. Cullinan MP, "Progression of periodontal disease and interleukin-10 gene polymorphism", J Periodontal Res, 43, pp.328~333 (2008)
  57. Yamashita K, "Effect of adoptive transfer of cloned Actinobacillus actinomycetemcomitans-specific T helper cells on periodontal disease", Infect Immun, 59, pp.1529~1534 (1991)
  58. Eastcott JW, "Adoptive transfer of cloned T helper cells ameliorates periodontal disease in nude rats", Oral Microbiol Immunol, 9, pp.284~289 (1994)
  59. Gemmell E, "Immunoregulatory control of Th1", Th2 cytokine profiles in periodontal disease, 2004, pp.35, 21~41
  60. Alayan J, "Alveolar bone loss in T helper 1", T helper 2 cytokine-deficient mice, 2007, pp.42, 97~103
  61. Belkaid Y, "Regulatory T cells and infection: a dangerous necessity", Nat Rev Immunol, 7, pp.875~888 (2007)
  62. Gmur R, "Dominant crossreactive antibodies generated during the response to a variety of oral bacterial species detect phosphorylcholine", J Dent Res, 78, pp.77~85 (1999)
  63. Laine ML, "Prevalence and distribution of six capsular serotypes of Porphyromonas gingivalis in periodontitis patients", J Dent Res, 76, pp.1840~1844 (1997)
  64. "Oral Microbiol Immunol", 1998, 55~58
  65. Maeda H, "Heat shock protein 60 (GroEL) from Porphyromonas gingivalis: molecular cloning and sequence analysis of its gene and purification of the recombinant protein", FEMS Microbiol Lett, 119, pp.129~135 (1994)
  66. Lee JY, "Porphyromonas gingivalis heat shock protein vaccine reduces the alveolar bone loss induced by multiple periodontopathogenic bacteria", J Periodontal Res, 41, pp.10~14 (2006)
  67. Choi JI, "Recognition and phagocytosis of multiple periodontopathogenic bacteria by anti-Porphyromonas gingivalis heat-shock protein 60 antisera", Oral Microbiol Immunol, 20, pp.51~55 (2005)
  68. Chang-Seo Park, "Identification of immunological parameters associated with the alveolar bone level in periodontal patients", Journal of Periodontal & Implant Science, 40(2), pp.61~68 (2010), 대한치주과학회
  69. Friedewald VE, "The American Journal of Cardiology and Journal of Periodontology editors’ consensus: periodontitis and atherosclerotic cardiovascular disease", J Periodontol, 80, pp.1021~1032 (2009)
  70. Van Eden W, "Stress, heat shock proteins, and autoimmunity: how immune responses to heat shock proteins are to be used for the control of chronic inflammatory diseases", Ann N Y Acad Sci, 1113, pp.217~237 (2007)
  71. Van Eden W, "Heat-shock proteins induce T-cell regulation of chronic inflammation", Nat Rev Immunol, 5, pp.318~330 (2005)
  72. Hansson GK, "The immune response in atherosclerosis:a double-edged sword", Nat Rev Immunol, 6, pp.508~519 (2006)
  73. Rajaiah R, "Heat-shock proteins can promote as well as regulate autoimmunity", Autoimmun Rev, 8, pp.388~393 (2009)
  74. Choi JI, "Establishment of Porphyromonas gingivalis heat-shock-proteinspecific T-cell lines from atherosclerosis patients", J Dent Res, 81, pp.344~348 (2002)
  75. Choi JI, "Epitope mapping of Porphyromonas gingivalis heatshock protein and human heat-shock protein in human atherosclerosis", J Dent Res, 83, pp.936~940 (2004)
  76. Choi J, "Establishment of Porphyromonas gingivalis-specific T-cell lines from atherosclerosis patients", Oral Microbiol Immunol, 16, pp.316~318 (2001)
  77. Choi JI, "Identification of T-cell epitopes of Porphyromonas gingivalis heat-shockprotein 60 in periodontitis", Oral Microbiol Immunol, 19, pp.1~5 (2004)
  78. 박정규, "동맥경화증에서 T-세포 및 B-세포에 대한 Porphyromonas gingivalis열충격 단백의 항원 결정 부위 특이성 연구", The Journal of the Korean Academy of Periodontology (JPIS), 33(2), pp.179~192 (2003), 대한치주과학회
  79. Choi JI, "Immunoreactivity of poly-specific peptide from Porphyromonas gingivalis heat shock protein (Abstract 2716)", 88th General Session & Exhibition of the IADR (2010), International Association for Dental Research
  80. Ma JK, "Generation and assembly of secretory antibodies in plants", Science, 268, pp.716~719 (1995)
  81. Shin EA, "Synthesis and assembly of an adjuvanted Porphyromonas gingivalis fimbrial antigen fusion protein in plants", Protein Expr Purif, 47, pp.99~109 (2006)
  82. Sharma A, "Secretion of Porphyromonas gingivalis fimbrillin polypeptides by recombinant Streptococcus gordonii", Biochem Biophys Res Commun, 238, pp.313~316 (1997)
  83. Sharma A, "Oral immunization with recombinant Streptococcus gordonii expressing porphyromonas gingivalis FimA domains", Infect Immun, 69, pp.2928~2934 (2001)

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