The biological effect of cyanoacrylate-combined calcium phosphate in rabbit calvarial defects
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Purpose: The purpose of this study was to determine the biological effects of cyanoacrylate-combined calcium phosphate (CCP), in particular its potential to act as a physical barrier - functioning like a membrane - in rabbit calvarial defects. Methods: In each animal, four circular calvarial defects with a diameter of 8 mm were prepared and then filled with either nothing (control group) or one of three different experimental materials. In the experimental conditions, they were filled with CCP alone (CCP group), filled with biphasic calcium phosphate (BCP) and then covered with an absorbable collagen sponge (ACS; BCP/ACS group), or filled with BCP and then covered by CCP (BCP/CCP group). Results: After 4 and 8 weeks of healing, new bone formation appeared to be lower in the CCP group than in the control group, but the difference was not statistically significant. In both the CCP and BCP/CCP groups, inflammatory cells could be seen after 4 and 8 weeks of healing. Conclusions: Within the limits of this study, CCP exhibited limited osteoconductivity in rabbit calvarial defects and was histologically associated with the presence of inflammatory cells. However, CCP demonstrated its ability to stabilize graft particles and its potential as an effective defect filler in bone augmentation, if the biocompatibility and osteoconductivity of CCP were improved.
Abstract
Purpose: The purpose of this study was to determine the biological effects of cyanoacrylate-combined calcium phosphate (CCP), in particular its potential to act as a physical barrier - functioning like a membrane - in rabbit calvarial defects. Methods: In each animal, four circular calvarial defects with a diameter of 8 mm were prepared and then filled with either nothing (control group) or one of three different experimental materials. In the experimental conditions, they were filled with CCP alone (CCP group), filled with biphasic calcium phosphate (BCP) and then covered with an absorbable collagen sponge (ACS; BCP/ACS group), or filled with BCP and then covered by CCP (BCP/CCP group). Results: After 4 and 8 weeks of healing, new bone formation appeared to be lower in the CCP group than in the control group, but the difference was not statistically significant. In both the CCP and BCP/CCP groups, inflammatory cells could be seen after 4 and 8 weeks of healing. Conclusions: Within the limits of this study, CCP exhibited limited osteoconductivity in rabbit calvarial defects and was histologically associated with the presence of inflammatory cells. However, CCP demonstrated its ability to stabilize graft particles and its potential as an effective defect filler in bone augmentation, if the biocompatibility and osteoconductivity of CCP were improved.
참고문헌 (27)
- Sculean A, "Regeneration of periodontal tissues: combinations of barrier membranes and grafting materials - biological foundation and preclinical evidence: a systematic review", J Clin Periodontol, 35(8), pp.106~116 (2008)
- Nkenke E, "Clinical outcomes of sinus floor augmentation for implant placement using autogenous bone or bone substitutes: a systematic review", Clin Oral Implants Res, 20(4), pp.124~133 (2009)
- Chiapasco M, "Clinical outcomes of GBR procedures to correct peri-implant dehiscences and fenestrations: a systematic review", Clin Oral Implants Res, 20(4), pp.113~123 (2009)
- Singer AJ, "A review of the literature on octylcyanoacrylate tissue adhesive", Am J Surg, 187, pp.238~248 (2004)
- Brown JK, "A prospective, randomized comparison of skin adhesive and subcuticular suture for closure of pediatric hernia incisions: cost and cosmetic considerations", J Pediatr Surg, 44, pp.1418~1422 (2009)
- Al-Belasy FA, "Hemostatic effect of n-butyl-2-cyanoacrylate (histoacryl) glue in warfarin-treated patients undergoing oral surgery", J Oral Maxillofac Surg, 61, pp.1405~1409 (2003)
- Quinn J, "Octylcyanoacrylate tissue adhesive versus suture wound repair in a contaminated wound model", Surgery, 122, pp.69~72 (1997)
- Eaglstein WH, "Cyanoacrylates for skin closure", Dermatol Clin, 23, pp.193~198 (2005)
- Singer AJ, "Evaluation of a new liquid occlusive dressing for excisional wounds", Wound Repair Regen, 11, pp.181~187 (2003)
- Singer A, "The effects of octylcyanoacrylate on scarring after burns", Acad Emerg Med, 8, pp.107~111 (2001)
- Kutcher M, "Evaluating the efficacy of 2-octyl cyanoacrylate bioadhesive for treatment of oral ulcerations", Compend Contin Educ Dent Suppl, 32, pp.12~16 (2001)
- Bhaskar SN, "Oral spray of isobutyl cyanoacrylate and its systemic effect", Oral Surg Oral Med Oral Pathol, 29, pp.313~319 (1970)
- Lee SB, "A histological evaluation of novel cyanoacrylate-based β-TCP composite in rat calvarial defects", KEY ENGINEERING MATERIALS, 309-311, pp.1133~1136 (2006), Trans Tech Publications Ltd
- Park KJ, "Bioactive cyanoacrylate-based filling material for bone defects in dental applications", KEY ENGINEERING MATERIALS, 284-286, pp.933~936 (2005), TRANS TECH PUBLICATIONS LTD
- Leggat PA, "Surgical applications of cyanoacrylate adhesives: a review of toxicity", ANZ J Surg, 77, pp.209~213 (2007)
- Jensen SS, "Bone healing and graft resorption of autograft, anorganic bovine bone and beta-tricalcium phosphate. A histologic and histomorphometric study in the mandibles of minipigs", Clin Oral Implants Res, 17, pp.237~243 (2006)
- Bowers GM, "Histologic observations following the placement of tricalcium phosphate implants in human intrabony defects", J Periodontol, 57, pp.286~287 (1986)
- 임지순, "The application of Cyanoacrylate-based Filling Material for Surgically Created 1-wall Intrabony Defects in Dogs", 생체재료학회지, 13(4), pp.128~132 (2009), 한국생체재료학회
- Dragu A, "Foreign body reaction after usage of tissue adhesives for skin closure: a case report and review of the literature", Arch Orthop Trauma Surg, 129, pp.167~169 (2009)
- Rengstorff DS, "A pilot study of 2-octyl cyanoacrylate injection for treatment of gastric fundal varices in humans", Gastrointest Endosc, 59, pp.553~558 (2004)
- Zhang CQ, "modified percutaneous transhepatic variceal embolization with 2-octyl cyanoacrylate versus endoscopic ligation in esophageal variceal bleeding management: randomized controlled trial", Dig Dis Sci, 53, pp.2258~2267 (2008)
- Losanoff JE, "Cyanoacrylate adhesive in management of severe presacral bleeding", Dis Colon Rectum, 45, pp.1118~1119 (2002)
- 김영균, "Clinical evaluations of OSTEON? as a new alloplastic material in sinus bone grafting and its effect on bone healing", Journal of Biomedical Materials Research - Part B Applied Biomaterials, 86(1), pp.270~277, John Wiley & Sons Inc.
- 엄유정, "토끼 두개골에서 새로 개발된 biphasic calcium phosphate의 골형성 효과 : A pilot study", Journal of Periodontal & Implant Science, 38(2), pp.163~170 (2008), 대한치주과학회
- Fleckenstein KB, "Effect of a hydroxyapatite tricalcium phosphate alloplast on osseous repair in the rat calvarium", J Periodontol, 77, pp.39~45 (2006)
- Yun-Young Chang,, "The Effects of Hydroxyapatite Coated with β-Tricalcium Phosphate in One-Wall Intrabony Defects in Dogs", 생체재료학회지, 14(3), pp.111~117 (2010), 한국생체재료학회
- Moreira-Gonzalez A, "Evaluation of 45S5 bioactive glass combined as a bone substitute in the reconstruction of critical size calvarial defects in rabbits", J Craniofac Surg, 16, pp.63~70 (2005)
