Is the relationship between periodontitis and hyperlipidemia mediated by lipoprotein-associated inflammatory mediators?
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Purpose: The aim of this study was to evaluate the serum levels of oxidized low-density lipoprotein (oxLDL), anti-oxLDL, and myeloperoxidase (MPO) in hyperlipidemic patients with periodontal disease. Methods: This study included 123 patients with hyperlipidemia categorized based on metabolic control as mild to moderate (H1) (n=66) or poor (H2) (n=57), as well as systemically healthy controls (C) (n=68). Serum levels of lipids, oxLDL, anti-oxLDL, and MPO were evaluated, along with clinical periodontal parameters. Results: The percentage of bleeding on probing (BOP%) and the clinical attachment level were significantly higher in the H2 group than in the C group. Patients with hyperlipidemia had a relatively high risk of developing periodontal disease. The oxLDL and anti-oxLDL levels were higher in H2 patients with periodontitis than in the control or H1 patients with periodontitis. In the H1 and H2 groups, the ratio of total cholesterol to high-density lipoprotein was significantly correlated with gingival index, BOP%, and oxLDL levels. Conclusions: Our findings indicate that the lipoprotein-associated inflammatory mediators of oxLDL, anti-oxLDL, and MPO may play an important role in the relationship between periodontal disease and hyperlipidemia.
Abstract
Purpose: The aim of this study was to evaluate the serum levels of oxidized low-density lipoprotein (oxLDL), anti-oxLDL, and myeloperoxidase (MPO) in hyperlipidemic patients with periodontal disease. Methods: This study included 123 patients with hyperlipidemia categorized based on metabolic control as mild to moderate (H1) (n=66) or poor (H2) (n=57), as well as systemically healthy controls (C) (n=68). Serum levels of lipids, oxLDL, anti-oxLDL, and MPO were evaluated, along with clinical periodontal parameters. Results: The percentage of bleeding on probing (BOP%) and the clinical attachment level were significantly higher in the H2 group than in the C group. Patients with hyperlipidemia had a relatively high risk of developing periodontal disease. The oxLDL and anti-oxLDL levels were higher in H2 patients with periodontitis than in the control or H1 patients with periodontitis. In the H1 and H2 groups, the ratio of total cholesterol to high-density lipoprotein was significantly correlated with gingival index, BOP%, and oxLDL levels. Conclusions: Our findings indicate that the lipoprotein-associated inflammatory mediators of oxLDL, anti-oxLDL, and MPO may play an important role in the relationship between periodontal disease and hyperlipidemia.
참고문헌 (39)
- Yusuf S, "Effect of potentially modifiable risk factors associated with myocardial infarction in 52 countries(the INTERHEART study) : case-control study", Lancet, 364, pp.937~952 (2004)
- Tsimikas S, "Oxidized phospholipids, Lp(a) lipoprotein, and coronary artery disease", N Engl J Med, 353, pp.46~57 (2005)
- D'Aiuto F, "Evidence that periodontal treatment improves biomarkers and CVD outcomes", J Periodontol, 84, pp.S85~105 (2013)
- Dietrich T, "The epidemiological evidence behind the association between periodontitis and incident atherosclerotic cardiovascular disease", J Periodontol, 84, pp.S70~84 (2013)
- Tsimikas S, "Pro-inflammatory interleukin-1 genotypes potentiate the risk of coronary artery disease and cardiovascular events mediated by oxidized phospholipids and lipoprotein(a)", J Am Coll Cardiol, 63, pp.1724~1734 (2014)
- Memon RA, "Infection and inflammation induce LDL oxidation in vivo", Arterioscler Thromb Vasc Biol, 20, pp.1536~1542 (2000)
- Steinberg D, "Atherogenesis in perspective : hypercholesterolemia and inflammation as partners in crime", Nat Med, 8, pp.1211~1217 (2002)
- Itabe H, "Oxidized low-density lipoprotein as a biomarker of in vivo oxidative stress : from atherosclerosis to periodontitis", J Clin Biochem Nutr, 51, pp.1~8 (2012)
- Cushing SD, "Minimally modified low density lipoprotein induces monocyte chemotactic protein 1 in human endothelial cells and smooth muscle cells", Proc Natl Acad Sci U S A, 87, pp.5134~5138 (1990)
- Delporte C, "Low-density lipoprotein modified by myeloperoxidase in inflammatory pathways and clinical studies", Mediators Inflamm, 2013, pp.971579~ (2013)
- Sokolov AV, "Proatherogenic modification of LDL by surface-bound myeloperoxidase", Chem Phys Lipids, 180, pp.72~80 (2014)
- Steinerová A, "Antibodies against oxidized LDL--theory and clinical use", Physiol Res, 50, pp.131~141 (2001)
- Buhlin K, "Risk factors for cardiovascular disease in patients with periodontitis", Eur Heart J, 24, pp.2099~2107 (2003)
- Teeuw WJ, "Treatment of periodontitis improves the atherosclerotic profile : a systematic review and meta-analysis", J Clin Periodontol, 41, pp.70~79 (2014)
- Fitzsimmons TR, "Local and systemic biomarkers in gingival crevicular fluid increase odds of periodontitis", J Clin Periodontol, 37, pp.30~36 (2010)
- Fentoğlu O, "Serum lipoprotein-associated phospholipase A2 and C-reactive protein levels in association with periodontal disease and hyperlipidemia", J Periodontol, 82, pp.350~359 (2011)
- Fentoğlu Ö, "Pro-inflammatory cytokine levels in association between periodontal disease and hyperlipidaemia", J Clin Periodontol, 38, pp.8~16 (2011)
- Silness J, "Periodontal disease in pregnancy. II. Correlation between oral hygiene and periodontal condition", Acta Odontol Scand, 22, pp.121~135 (1964)
- Loe H, "Periodontal disease in pregnancy. I. Prevalence and severity", Acta Odontol Scand, 21, pp.533~551 (1963)
- Chapple IL, "Periodontal health and gingival diseases and conditions on an intact and a reduced periodontium: consensus report of workgroup 1 of the 2017 world workshop on the classification of periodontal and peri-implant diseases and conditions", J Periodontol, 89(Suppl 1), pp.S74~S84 (2018)
- Tonetti MS, "Staging and grading of periodontitis : framework and proposal of a new classification and case definition", J Clin Periodontol, 45(Suppl 20), pp.S149~S161 (2018)
- Grundy SM, "Implications of recent clinical trials for the national cholesterol education program adult treatment panel III guidelines", Circulation, 110, pp.227~239 (2004)
- Van Lenten BJ, "The role of lipoproteins and receptor-mediated endocytosis in the transport of bacterial lipopolysaccharide", Proc Natl Acad Sci U S A, 83, pp.2704~2708 (1986)
- Naito HK, "The association of serum lipids, lipoproteins, and apolipoproteins with coronary artery disease assessed by coronary arteriography", Ann N Y Acad Sci, 454, pp.230~238 (1985)
- Maglakelidze N, "Functional-morphologic aspects of changes of mucosal gingiva microcirculatory bed vessels in experimental gingivitis against the background of hypercholesterolemia", Georgian Med News, pp.71~74 (2005)
- Penumarthy S, "Assessment of serum levels of triglycerides, total cholesterol, high-density lipoprotein cholesterol, and low-density lipoprotein cholesterol in periodontitis patients", J Indian Soc Periodontol, 17, pp.30~35 (2013)
- Türkoğlu O, "Evaluation of serum anti-cardiolipin and oxidized low-density lipoprotein levels in chronic periodontitis patients with essential hypertension", J Periodontol, 79, pp.332~340 (2008)
- Tamaki N, "Periodontal treatment decreases plasma oxidized LDL level and oxidative stress", Clin Oral Investig, 15, pp.953~958 (2011)
- Shah R, "Oxidized-low density lipoprotein in gingival crevicular fluid of patients with chronic periodontitis : a possible link to atherogenesis", Acta Odontol Scand, 72, pp.154~156 (2014)
- Miyasaki KT, "The neutrophil : mechanisms of controlling periodontal bacteria", J Periodontol, 62, pp.761~774 (1991)
- Van Dyke TE, "Neutrophil chemotaxis dysfunction in human periodontitis", Infect Immun, 27, pp.124~132 (1980)
- Jovinge S, "Human monocytes", macrophages release TNF-alpha in response to ox-LDL, 1996, pp.16, 1573~1579
- Dutta-Roy AK, "Insulin mediated processes in platelets, erythrocytes and monocytes", macrophages: effects of essential fatty acid metabolism, 1994, pp.51, 385~399
- Nicholls SJ, "Myeloperoxidase, modified lipoproteins, and atherogenesis", J Lipid Res, 50(Suppl), pp.S346~S351 (2009)
- Boudjeltia KZ, "Myeloperoxidase-dependent LDL modifications in bloodstream are mainly predicted by angiotensin II, adiponectin, and myeloperoxidase activity: a cross-sectional study in men", Mediators Inflamm, 2013, pp.750742~ (2013)
- Klebanoff SJ, "Myeloperoxidase : a front-line defender against phagocytosed microorganisms", J Leukoc Biol, 93, pp.185~198 (2013)
- Kinane DF, "Immune processes in periodontal disease : a review", Ann Periodontol, 7, pp.62~71 (2002)
- Fentoğlu O, "Short-term effects of periodontal therapy as an adjunct to anti-lipemic treatment", Oral Dis, 16, pp.648~654 (2010)
- Petersen KS, "The association between carotid intima media thickness and individual dietary components and patterns", Nutr Metab Cardiovasc Dis, 24, pp.495~502 (2014)