Measurement of atherosclerosis markers in individuals with periodontitis
2
조회
0
다운로드
0
인용
0
참고문헌
키워드
초록
Purpose: The inflammatory response due to inflammatory cytokines, bacterial pathogens, and the altered lipoprotein metabolism in patients with periodontitis indicates that infection with periodontal anaerobic bacteria may influence atherogenesis in vitro and in vivo. We aimed to explore the effect of periodontitis concerning clinical and ultrasound markers of early atherosclerosis. Methods: In this case-control study, a total of 30 systemically healthy adults (15 with periodontitis and 15 without periodontitis) over 40 years of age were studied. Periodontitis was determined by measuring the clinical attachment level (CAL) and radiographic bone loss (RBL). Conventional cardiovascular risk factors, including body mass index, serum levels of total cholesterol (TCH), triglycerides (TG), and high-density and low-density lipoprotein (HDL and LDL, respectively) cholesterol were evaluated. Carotid artery intima-media thickness (IMT) was measured using ultrasonography. Results: The mean values of the CAL and carotid IMT were 5.02±0.9 mm and 0.084±0.01 cm vs. 1.6±0.61 mm and 0.072±0.02 cm in the periodontitis and healthy groups, respectively, reflecting statistically significant differences (P=0.001 and P=0.037, respectively). There were statistically significant differences in the serum levels of TCH, TG, and LDL between the 2 groups (P=0.017). The CAL and RBL were positively associated with carotid IMT and serum cholesterol levels, except for HDL, whereas tooth loss was not associated with any markers (P<0.05). Compared to the healthy group, participants with periodontitis exhibited 2.09 times higher odds (95% confidence interval, 1.22–3.59) of having subclinical atherosclerosis. Conclusions: The presence of periodontitis increased the risk of atherosclerosis.
Abstract
Purpose: The inflammatory response due to inflammatory cytokines, bacterial pathogens, and the altered lipoprotein metabolism in patients with periodontitis indicates that infection with periodontal anaerobic bacteria may influence atherogenesis in vitro and in vivo. We aimed to explore the effect of periodontitis concerning clinical and ultrasound markers of early atherosclerosis. Methods: In this case-control study, a total of 30 systemically healthy adults (15 with periodontitis and 15 without periodontitis) over 40 years of age were studied. Periodontitis was determined by measuring the clinical attachment level (CAL) and radiographic bone loss (RBL). Conventional cardiovascular risk factors, including body mass index, serum levels of total cholesterol (TCH), triglycerides (TG), and high-density and low-density lipoprotein (HDL and LDL, respectively) cholesterol were evaluated. Carotid artery intima-media thickness (IMT) was measured using ultrasonography. Results: The mean values of the CAL and carotid IMT were 5.02±0.9 mm and 0.084±0.01 cm vs. 1.6±0.61 mm and 0.072±0.02 cm in the periodontitis and healthy groups, respectively, reflecting statistically significant differences (P=0.001 and P=0.037, respectively). There were statistically significant differences in the serum levels of TCH, TG, and LDL between the 2 groups (P=0.017). The CAL and RBL were positively associated with carotid IMT and serum cholesterol levels, except for HDL, whereas tooth loss was not associated with any markers (P<0.05). Compared to the healthy group, participants with periodontitis exhibited 2.09 times higher odds (95% confidence interval, 1.22–3.59) of having subclinical atherosclerosis. Conclusions: The presence of periodontitis increased the risk of atherosclerosis.
참고문헌 (22)
- Lamont RJ, "The oral microbiota : dynamic communities and host interactions", Nat Rev Microbiol, 16, pp.745~759 (2018)
- Kinane DF, "Periodontal manifestations of systemic disease", Aust Dent J, 46, pp.2~12 (2001)
- Jargaltsogt D, "The results of national oral health survey, Mongolia", Cent Asian J Med Sci, 4, pp.61~68 (2018)
- Jung YS, "Relationship between periodontal disease and subclinical atherosclerosis : the Dong-gu study", J Clin Periodontol, 41, pp.262~268 (2014)
- Newman MG, "Carranza’s clinical periodontology" (2006), Saunder Elsevier
- Tabeta K, "Current evidence and biological plausibility linking periodontitis to atherosclerotic cardiovascular disease", Jpn Dent Sci Rev, 50, pp.55~62 (2014)
- Bui FQ, "Association between periodontal pathogens and systemic disease", Biomed J, 42, pp.27~35 (2019)
- Sen S, "Periodontal disease, regular dental care use, and incident ischemic stroke", Stroke, 49, pp.355~362 (2018)
- Kim HJ, "Porphyromonas gingivalis accelerates atherosclerosis through oxidation of high-density lipoprotein", J Periodontal Implant Sci, 48, pp.60~68 (2018)
- Orlandi M, "Periodontal therapy and cardiovascular risk", Periodontol 2000, 83, pp.107~124 (2020)
- Kudo C, "Effects of periodontal treatment on carotid intima-media thickness in patients with lifestyle-related diseases : Japanese prospective multicentre observational study", Odontology, 106, pp.316~327 (2018)
- Nitya KN, "Assessment of periodontal status based on carotid artery intima media thickness", Oral Health Prev Dent, 18, pp.511~519 (2020)
- Pinho MM, "Periodontitis and atherosclerosis : an observational study", J Periodontal Res, 48, pp.452~457 (2013)
- Ahn YB, "Periodontitis is associated with the risk of subclinical atherosclerosis and peripheral arterial disease in Korean adults", Atherosclerosis, 251, pp.311~318 (2016)
- World Health Organization, "Oral health surveys: basic methods" (2013), World Health Organization Press
- Lang NP, "Periodontal health", J Clin Periodontol, 45(Suppl 20), pp.S9~S16 (2018)
- López-Jornet P, "Measurement of atherosclerosis markers in patients with periodontitis : a case-control study", J Periodontol, 83, pp.690~698 (2012)
- Jeong IB, "The carotid intima-media thickness as a screening test for coronary artery disease", Korean Circ J, 35, pp.460~466 (2005)
- Hajishengallis G, "Periodontitis : from microbial immune subversion to systemic inflammation", Nat Rev Immunol, 15, pp.30~44 (2015)
- Stewart R, "Increasing evidence for an association between periodontitis and cardiovascular disease", Circulation, 133, pp.549~551 (2016)
- Zeng XT, "Periodontal disease and carotid atherosclerosis : a meta-analysis of 17, 330 participants", Int J Cardiol, 203, pp.1044~1051 (2016)
- Griffiths R, "Lipoproteins and lipoprotein metabolism in periodontal disease", Clin Lipidol, 5, pp.397~411 (2010)