Clinical and microbiological effects of adjunctive local delivery of minocycline (Periocline®) in patients receiving supportive periodontal therapy: a pilot study
2
조회
0
다운로드
0
인용
0
참고문헌
키워드
초록
Purpose: This study aimed to evaluate the clinical and microbiological efficacy of adjunctive local delivery of minocycline (Periocline®) in patients receiving supportive periodontal therapy (SPT) after initial treatment. Methods: The participants were 16 men and 8 women (age, 20–65 years) who had at least 15 natural teeth, underwent SPT for more than 1 year due to chronic periodontitis, had 4 or more periodontal pocket sites deeper than 5 mm, and showed >25% gingival bleeding on probing (BoP). They were randomly assigned to the test and control groups. In the test group, mechanical debridement and local antibiotic delivery were performed for all periodontal sulci/pockets; in the control group, mechanical debridement and saline irrigation were performed. In patients who underwent SPT for more than 1 year, clinical and microbiological examinations were performed at baseline and 1 and 3 months after SPT. The clinical examination included an assessment of the periodontal pocket depth, clinical attachment level, plaque index, and BoP. Microbial tests were performed using real-time polymerase chain reaction; the relative ratios of Porphyromonas gingivalis and Fusobacterium nucleatum were determined. Results: Both groups showed significant improvements in clinical parameters at 1 and 3 months from baseline; there were no significant changes between months 1 and 3. Intergroup differences were insignificant. The microbiological analysis revealed no significant differences in P. gingivalis and F. nucleatum ratios across time points. While intergroup differences were insignificant, there was a tendency for the P. gingivalis and F. nucleatum ratios to decrease in the test group. Conclusions: Mechanical debridement in patients receiving maintenance therapy resulted in clinically significant improvement; the effectiveness of additional local delivery of antibiotics was not significant. The ratios of P. gingivalis and F. nucleatum showed a tendency to decrease in the test group, although it was not significant.
Abstract
Purpose: This study aimed to evaluate the clinical and microbiological efficacy of adjunctive local delivery of minocycline (Periocline®) in patients receiving supportive periodontal therapy (SPT) after initial treatment. Methods: The participants were 16 men and 8 women (age, 20–65 years) who had at least 15 natural teeth, underwent SPT for more than 1 year due to chronic periodontitis, had 4 or more periodontal pocket sites deeper than 5 mm, and showed >25% gingival bleeding on probing (BoP). They were randomly assigned to the test and control groups. In the test group, mechanical debridement and local antibiotic delivery were performed for all periodontal sulci/pockets; in the control group, mechanical debridement and saline irrigation were performed. In patients who underwent SPT for more than 1 year, clinical and microbiological examinations were performed at baseline and 1 and 3 months after SPT. The clinical examination included an assessment of the periodontal pocket depth, clinical attachment level, plaque index, and BoP. Microbial tests were performed using real-time polymerase chain reaction; the relative ratios of Porphyromonas gingivalis and Fusobacterium nucleatum were determined. Results: Both groups showed significant improvements in clinical parameters at 1 and 3 months from baseline; there were no significant changes between months 1 and 3. Intergroup differences were insignificant. The microbiological analysis revealed no significant differences in P. gingivalis and F. nucleatum ratios across time points. While intergroup differences were insignificant, there was a tendency for the P. gingivalis and F. nucleatum ratios to decrease in the test group. Conclusions: Mechanical debridement in patients receiving maintenance therapy resulted in clinically significant improvement; the effectiveness of additional local delivery of antibiotics was not significant. The ratios of P. gingivalis and F. nucleatum showed a tendency to decrease in the test group, although it was not significant.
참고문헌 (24)
- Hung HC, "Meta-analysis of the effect of scaling and root planing, surgical treatment and antibiotic therapies on periodontal probing depth and attachment loss", J Clin Periodontol, 29, pp.975~986 (2002)
- Caffesse RG, "Scaling and root planing with and without periodontal flap surgery", J Clin Periodontol, 13, pp.205~210 (1986)
- Greenstein G, "The role of controlled drug delivery for periodontitis. The Research, Science and Therapy Committee of the American Academy of Periodontology", J Periodontol, 71, pp.125~140 (2000)
- Ji S, "Bacterial invasion and persistence: critical events in the pathogenesis of periodontitis?", J Periodontal Res, 50, pp.570~585 (2015)
- Ciancio SG, "An evaluation of minocycline in patients with periodontal disease", J Periodontol, 51, pp.530~534 (1980)
- Ciancio SG, "The effect of short-term administration of minocycline HCl on gingival inflammation and subgingival microflora", J Periodontol, 53, pp.557~561 (1982)
- Bogren A, "Locally delivered doxycycline during supportive periodontal therapy : a 3-year study", J Periodontol, 79, pp.827~835 (2008)
- Soeroso Y, "The risk reduction of recurrent periodontal pathogens of local application minocycline HCl 2% gel, used as an adjunct to scaling and root planing for chronic periodontitis treatment", Ther Clin Risk Manag, 13, pp.307~314 (2017)
- Timmerman MF, "Evaluation of the long-term efficacy and safety of locally-applied minocycline in adult periodontitis patients", J Clin Periodontol, 23, pp.707~716 (1996)
- Murayama Y, "Local administration of minocycline for periodontitis. Double blind comparative study of LS-007", Nippon Shishubyo Gakkai Kaishi, 30, pp.206~222 (1988)
- van Steenberghe D, "Subgingival minocycline hydrochloride ointment in moderate to severe chronic adult periodontitis: a randomized, double-blind, vehicle-controlled, multicenter study", J Periodontol, 64, pp.637~644 (1993)
- van Steenberghe D, "A 15-month evaluation of the effects of repeated subgingival minocycline in chronic adult periodontitis", J Periodontol, 70, pp.657~667 (1999)
- Shiloah J, "Repopulation of periodontal pockets by microbial pathogens in the absence of supportive therapy", J Periodontol, 67, pp.130~139 (1996)
- Albert-Kiszely A, "Comparison of the effects of cetylpyridinium chloride with an essential oil mouth rinse on dental plaque and gingivitis-a six-month randomized controlled clinical trial", J Clin Periodontol, 34, pp.658~667 (2007)
- Querido SM, "Clinical and microbial evaluation of dental scaling associated with subgingival minocycline in chronic periodontitis subjects", Braz Oral Res, 18, pp.110~115 (2004)
- Lyons SR, "Quantitative real-time PCR for Porphyromonas gingivalis and total bacteria", J Clin Microbiol, 38, pp.2362~2365 (2000)
- Kato H, "Quantitative detection of volatile sulfur compoundproducing microorganisms in oral specimens using real-time PCR", Oral Dis, 11(Suppl 1), pp.67~71 (2005)
- Yoshida A, "Development of a 5′ fluorogenic nucleasebased real-time PCR assay for quantitative detection of Actinobacillus actinomycetemcomitans and Porphyromonas gingivalis", J Clin Microbiol, 41, pp.863~866 (2003)
- Williams RC, "Treatment of periodontitis by local administration of minocycline microspheres : a controlled trial", J Periodontol, 72, pp.1535~1544 (2001)
- Paquette D, "Locally delivered minocycline microspheres for the treatment of periodontitis in smokers", J Clin Periodontol, 30, pp.787~794 (2003)
- Jones AA, "Clinical and microbiological effects of controlledrelease locally delivered minocycline in periodontitis", J Periodontol, 65, pp.1058~1066 (1994)
- Matesanz-Pérez P, "A systematic review on the effects of local antimicrobials as adjuncts to subgingival debridement, compared with subgingival debridement alone, in the treatment of chronic periodontitis", J Clin Periodontol, 40, pp.227~241 (2013)
- Renvert S, "Supportive periodontal therapy", Periodontol 2000, 36, pp.179~195 (2004)
- Nakagawa T, "Clinical and microbiological study of local minocycline delivery(Periocline)following scaling and root planing in recurrent periodontal pockets", Bull Tokyo Dent Coll, 32, pp.63~70 (1991)