본문 바로가기
KERD
논문KCI 등재

MicroRNAs and periodontal disease: a qualitative systematic review of human studies

1

조회

0

다운로드

0

인용

0

참고문헌

키워드

주제분류치의학

초록

Purpose: MicroRNAs (miRNAs) are epigenetic post-transcriptional regulators that modulate gene expression and have been identified as biomarkers for several diseases, including cancer. This study aimed to systematically review the relationship between miRNAs and periodontal disease in humans, and to evaluate the potential of miRNAs as diagnostic and prognostic biomarkers of disease. Methods: The review was conducted following the Preferred Reporting Items for Systematic Reviews and Meta-Analysis guidelines (reference number CRD42020180683). The MEDLINE, Scopus, Cochrane Library, Embase, Web of Science, and SciELO databases were searched for clinical studies conducted in humans investigating periodontal diseases and miRNAs. Expression levels of miRNAs across the different groups were analysed using the collected data. Results: A total of 1,299 references were identified in the initial literature search, and 23 articles were finally included in the review. The study designs were heterogeneous, which prevented a meta-analysis of the data. Most of the studies compared miRNA expression levels between patients with periodontitis and healthy controls. The most widely researched miRNA in periodontal diseases was miR-146a. Most studies reported higher expression levels of miR-146a in patients with periodontitis than in healthy controls. In addition, many studies also focused on identifying target genes of the differentially expressed miRNAs that were significantly related to periodontal inflammation. Conclusions: The results of the studies that we analysed are promising, but diagnostic tests are needed to confirm the use of miRNAs as biomarkers to monitor and aid in the early diagnosis of periodontitis in clinical practice.

Abstract

Purpose: MicroRNAs (miRNAs) are epigenetic post-transcriptional regulators that modulate gene expression and have been identified as biomarkers for several diseases, including cancer. This study aimed to systematically review the relationship between miRNAs and periodontal disease in humans, and to evaluate the potential of miRNAs as diagnostic and prognostic biomarkers of disease. Methods: The review was conducted following the Preferred Reporting Items for Systematic Reviews and Meta-Analysis guidelines (reference number CRD42020180683). The MEDLINE, Scopus, Cochrane Library, Embase, Web of Science, and SciELO databases were searched for clinical studies conducted in humans investigating periodontal diseases and miRNAs. Expression levels of miRNAs across the different groups were analysed using the collected data. Results: A total of 1,299 references were identified in the initial literature search, and 23 articles were finally included in the review. The study designs were heterogeneous, which prevented a meta-analysis of the data. Most of the studies compared miRNA expression levels between patients with periodontitis and healthy controls. The most widely researched miRNA in periodontal diseases was miR-146a. Most studies reported higher expression levels of miR-146a in patients with periodontitis than in healthy controls. In addition, many studies also focused on identifying target genes of the differentially expressed miRNAs that were significantly related to periodontal inflammation. Conclusions: The results of the studies that we analysed are promising, but diagnostic tests are needed to confirm the use of miRNAs as biomarkers to monitor and aid in the early diagnosis of periodontitis in clinical practice.

참고문헌 (40)

  1. Chapple ILC, "The role of reactive oxygen and antioxidant species in periodontal tissue destruction", Periodontol 2000, 43, pp.160~232 (2007)
  2. Preshaw PM, "Current concepts in periodontal pathogenesis", Dent Update, 31, pp.570~572 (2004)
  3. Van Dyke TE, "Commentary : periodontitis is characterized by an immuno-inflammatory host-mediated destruction of bone and connective tissues that support the teeth", J Periodontol, 85, pp.509~511 (2014)
  4. Huang W, "Interleukin-1β rs1143627 polymorphism with susceptibility to periodontal disease", Oncotarget, 8, pp.31406~31414 (2017)
  5. Rodenhiser D, "Epigenetics and human disease : translating basic biology into clinical applications", CMAJ, 174, pp.341~348 (2006)
  6. Behm-Ansmant I, "MicroRNAs silence gene expression by repressing protein expression and", or by promoting mRNA decay, 2006, pp.71, 523~530
  7. Almiñana-Pastor PJ, "Epigenetics and periodontics : a systematic review", Med Oral Patol Oral Cir Bucal, 24, pp.e659~72 (2019)
  8. Dai R, "MicroRNA, a new paradigm for understanding immunoregulation, inflammation, and autoimmune diseases", Transl Res, 157, pp.163~179 (2011)
  9. Hammond SM, "An overview of microRNAs", Adv Drug Deliv Rev, 87, pp.3~14 (2015)
  10. Palanisamy V, "Control of cytokine mRNA expression by RNA-binding proteins and microRNAs", J Dent Res, 91, pp.651~658 (2012)
  11. Peng Y, "The role of MicroRNAs in human cancer", Signal Transduct Target Ther, 1, pp.15004~ (2016)
  12. Melak T, "Circulating microRNAs as possible biomarkers for coronary artery disease : a narrative review", EJIFCC, 30, pp.179~194 (2019)
  13. Poy MN, "microRNAs and the regulation of glucose and lipid metabolism", Diabetes Obes Metab, 9(Suppl 2), pp.67~73 (2007)
  14. Keller A, "Toward the blood-borne miRNome of human diseases", Nat Methods, 8, pp.841~843 (2011)
  15. Armitage GC, "Development of a classification system for periodontal diseases and conditions", Ann Periodontol, 4, pp.1~6 (1999)
  16. Ogata Y, "MicroRNA expression in inflamed and noninflamed gingival tissues from Japanese patients", J Oral Sci, 56, pp.253~260 (2014)
  17. Venugopal P, "Association of microRNA-125a and microRNA-499a polymorphisms in chronic periodontitis in a sample south Indian population : a hospital-based genetic association study", Gene, 631, pp.10~15 (2017)
  18. Kalea AZ, "Upregulation of gingival tissue miR200b in obese periodontitis subjects", J Dent Res, 94, pp.59~ (2015)[DOI]
  19. Naqvi AR, "Dysregulation of human miRNAs and increased prevalence of HHV miRNAs in obese periodontitis subjects", J Clin Periodontol, 46, pp.51~61 (2019)
  20. Perri R, "MicroRNA modulation in obesity and periodontitis", J Dent Res, 91, pp.33~38 (2012)
  21. Radović N, "MicroRNA-146a and microRNA-155 as novel crevicular fluid biomarkers for periodontitis in non-diabetic and type 2 diabetic patients", J Clin Periodontol, 45, pp.663~671 (2018)
  22. Bagavad Gita J, "Dysregulation of miR-146a by periodontal pathogens : A risk for acute coronary syndrome", J Periodontol, 90, pp.756~765 (2019)
  23. Yagnik K, "The periodontal-cardiovascular alliance : evaluation of miRNA-146a in subgingival plaque samples of chronic periodontitis patients with and without coronary heart disease", J Investig Clin Dent, 10, pp.e12442~ (2019)
  24. Chen H, "Abnormal expression of long noncoding RNA FGD5-AS1 affects the development of periodontitis through regulating miR-142-3p", SOCS6, Artif Cells Nanomed Biotechnol, pp.2019, 47[DOI]
  25. Ghotloo S, "Assessment of microRNA-146a in generalized aggressive periodontitis and its association with disease severity", J Periodontal Res, 54, pp.27~32 (2019)
  26. Kadkhodazadeh M, "MiR146a and MiR499 gene polymorphisms in Iranian periodontitis and peri-implantitis patients", J Long Term Eff Med Implants, 23, pp.9~16 (2013)
  27. Lee YH, "Comparison of inflammatory microRNA expression in healthy and periodontitis tissues", Biocell, 35, pp.43~49 (2011)
  28. Li J, "Assessment of microRNA-144-5p and its putative targets in inflamed gingiva from chronic periodontitis patients", J Periodontal Res, 54, pp.266~277 (2019)
  29. Micó-Martínez P, "miR-1226 detection in GCF as potential biomarker of chronic periodontitis : a pilot study", Med Oral Patol Oral Cir Bucal, 23, pp.e308~14 (2018)
  30. Motedayyen H, "Evaluation of microRNA-146a and its targets in gingival tissues of patients with chronic periodontitis", J Periodontol, 86, pp.1380~1385 (2015)
  31. Na HS, "Elevated microrna-128 in periodontitis mitigates tumor necrosis factor-α response via p38 signaling pathway in macrophages", J Periodontol, 87, pp.e173~82 (2016)
  32. Nisha KJ, "Identification of a novel salivary biomarker miR-143-3p for periodontal diagnosis : a proof of concept study", J Periodontol, 90, pp.1149~1159 (2019)
  33. Saito A, "MicroRNA profiling in gingival crevicular fluid of periodontitis-a pilot study", FEBS Open Bio, 7, pp.981~994 (2017)
  34. Stoecklin-Wasmer C, "MicroRNAs and their target genes in gingival tissues", J Dent Res, 91, pp.934~940 (2012)
  35. Venugopal P, "Differential expression of microRNAs let-7a, miR-125b, miR-100, and miR-21 and interaction with NF-kB pathway genes in periodontitis pathogenesis", J Cell Physiol, 233, pp.5877~5884 (2018)
  36. Xie YF, "Comparison of microRNA profiles of human periodontal diseased and healthy gingival tissues", Int J Oral Sci, 3, pp.125~134 (2011)
  37. Yoneda T, "Serum microRNAs and chronic periodontitis : a case-control study", Arch Oral Biol, 101, pp.57~63 (2019)
  38. Venugopal P, "Evaluation of a panel of single-nucleotide polymorphisms in miR-146a and miR-196a2 genomic regions in patients with chronic periodontitis", Genet Test Mol Biomarkers, 21, pp.228~235 (2017)
  39. Taganov KD, "NF-kappaB-dependent induction of microRNA miR146, an inhibitor targeted to signaling proteins of innate immune responses", Proc Natl Acad Sci U S A, 103, pp.12481~12486 (2006)
  40. Asa'ad F, "Expression of microRNAs in periodontal and periimplant diseases : a systematic review and meta-analysis", Int J Mol Sci, 21, pp.4147~ (2020)

관련 논문AI추천

Differential expression of microRNAs in the saliva of patients with aggressive periodontitis: a pilot study of potential biomarkers for aggressive periodontitis이은혜, Nam-Hun Lee, Su-Hwan Kim, Won-Kyung Kim, Young-Kyoo Lee, Young-Sung Kim대한치주과학회 · Journal of Periodontal & Implant Science2020 · 제50권 제5호Differential Expression Profiling of Salivary Exosomal microRNAs in a Single Case of Periodontitis - A Pilot Study김민석, 박성남, 손영우, 유형근, 최은주대한구강생물학회 · International Journal of Oral Biology2018 · 제43권 제4호Epigenetic biomarkers: a step forward for understanding periodontitis박윤정, Anders M. Lindroth대한치주과학회 · Journal of Periodontal & Implant Science2013 · 제43권 제3호Periodontopathogen LPSs Regulate MicroRNA Expression in Human Gingival Epithelial Cells정진, 나희삼, 박혜련, 정성희, Hwa Sun Lee, So-Yeon Jeong대한구강생물학회 · International Journal of Oral Biology2011 · 제36권 제3호Transcriptomic profiles and their correlations in saliva and gingival tissue biopsy samples from periodontitis and healthy patients이중석, 이지현, 전윤선, 차재국, 최성호대한치주과학회 · Journal of Periodontal & Implant Science2020 · 제50권 제5호Biomarkers associated with periodontitis and peri-implantitis: a systematic reviewAmardip Singh Kalsi, Federico Moreno, Haralampos Petridis대한치주과학회 · Journal of Periodontal & Implant Science2021 · 제51권 제1호

이 간행물의 다른 논문 (6건)