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백서두개골 결손부에서 BMP전달체의 골재생효과분석

The Analysis of Bone regenerative effect with carriers of bone morphogenetic protein in rat calvarial defects

김종관|최성호|김창성|정지희|조규성|채중규|채경준|정의원|정성원
대한치주과학회 (The Korean Academy Of Periodontology)|2007.12|Journal of Periodontal & Implant Science|제37권 제4호|pp. 733-742

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참고문헌

키워드

carrierBone morphogenetic proteinrat calvarial defect model
주제분류치의학

초록

Bone morphogenetic proteins have been shown to possess significant osteoinSductive potential, but in order to take advantage of this effect for tissue engineering, carrier systems are essential. Successful carrier systems must enable vascular and cellular invasion, allowing BMP to act as a differentiation factor. The carrier should be reproducible, non-immunogenic, moldable, and space-providing, to define the contours of the resulting bone. The purpose of this study was to review available literature, in comparing various carriers of BMP on rat calvarial defect model. The following conclusions were deduced. 1. Bone regeneration of ACS/BMP, β-TCP/BMP, FFSS/BMP, FFSS/β-TCP/BMP, MBCP/BMP group were significantly greater than the control groups. 2. Bone density in the ACS/BMP group was greater than that in β-TCP, FFSS, FFSS/β-TCP carrier group. 3. Bone regeneration in FFSS/BMP group was less than in ACS/BMP, β-TCP/BMP, MBCP/BMP group. However, New bone area of FFSS/β-TCP/BMP carrier group were more greater than that of FFSS/BMP group. ACS, β-TCP, FFSS, FFSS/β-TCP, MBCP were used for carrier of BMP. However, an ideal carrier which was reproducible, non-immunogenic, moldable, and space-providing did not exist. Therefore, further investigation are required in developing a new carrier system.

Abstract

Bone morphogenetic proteins have been shown to possess significant osteoinSductive potential, but in order to take advantage of this effect for tissue engineering, carrier systems are essential. Successful carrier systems must enable vascular and cellular invasion, allowing BMP to act as a differentiation factor. The carrier should be reproducible, non-immunogenic, moldable, and space-providing, to define the contours of the resulting bone. The purpose of this study was to review available literature, in comparing various carriers of BMP on rat calvarial defect model. The following conclusions were deduced. 1. Bone regeneration of ACS/BMP, β-TCP/BMP, FFSS/BMP, FFSS/β-TCP/BMP, MBCP/BMP group were significantly greater than the control groups. 2. Bone density in the ACS/BMP group was greater than that in β-TCP, FFSS, FFSS/β-TCP carrier group. 3. Bone regeneration in FFSS/BMP group was less than in ACS/BMP, β-TCP/BMP, MBCP/BMP group. However, New bone area of FFSS/β-TCP/BMP carrier group were more greater than that of FFSS/BMP group. ACS, β-TCP, FFSS, FFSS/β-TCP, MBCP were used for carrier of BMP. However, an ideal carrier which was reproducible, non-immunogenic, moldable, and space-providing did not exist. Therefore, further investigation are required in developing a new carrier system.

참고문헌 (31)

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