Serum Vitamin D Status in Iranian Fibromyalgia Patients: according to the Symptom Severity and Illness Invalidation
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Background: This study was designed to assess serum vitamin D status (25-OHD) in the fibromyalgia (FM) patients and to compare it with a healthy control group. It also aimed to investigate the correlation of serum vitamin D level with FM symptom severity and invalidation experiences. Methods: A total of 74 consecutive patients with FM and 68 healthy control participants were enrolled. The eligible FM patients completed the Illness Invalidation Inventory (3*I), the Revised Fibromyalgia Impact Questionnaire (FIQR) and a short-form health survey (SF-12). Venous blood samples were drawn from all participants to evaluate serum 25-OHD levels. Mann-Whitney tests and multiple logistic regression analyses were performed and Spearman’s correlations were calculated.Results: 88.4% of FM patients had low levels of serum 25-OHD. FM patients had significantly higher level of serum 25-OHD than the control group (17.24 ± 13.50 and 9.91 ± 6.47 respectively, P = 0.0001). There were no significant correlations between serum 25-OHD levels and the clinical measures of disease impact, invalidation dimensions, and health status. Multiple logistic regression analyses revealed that an increased discounting of the disease by the patient’s spouse was associated with a 4-fold increased risk for vitamin D deficiency (OR = 4.36; 95% CI, 0.95−19.87, P = 0.05). Conclusions: This study showed that although high rates of vitamin D insufficiency or deficiency were seen among FM patients and healthy non-FM participants, but it seems there was no intrinsic association between FM and vitamin D deficiency. Addressing of invalidation experience especially by the patient’s spouse is important in management of FM. (Korean J Pain 2016; 29: 172-8)
Abstract
Background: This study was designed to assess serum vitamin D status (25-OHD) in the fibromyalgia (FM) patients and to compare it with a healthy control group. It also aimed to investigate the correlation of serum vitamin D level with FM symptom severity and invalidation experiences. Methods: A total of 74 consecutive patients with FM and 68 healthy control participants were enrolled. The eligible FM patients completed the Illness Invalidation Inventory (3*I), the Revised Fibromyalgia Impact Questionnaire (FIQR) and a short-form health survey (SF-12). Venous blood samples were drawn from all participants to evaluate serum 25-OHD levels. Mann-Whitney tests and multiple logistic regression analyses were performed and Spearman’s correlations were calculated.Results: 88.4% of FM patients had low levels of serum 25-OHD. FM patients had significantly higher level of serum 25-OHD than the control group (17.24 ± 13.50 and 9.91 ± 6.47 respectively, P = 0.0001). There were no significant correlations between serum 25-OHD levels and the clinical measures of disease impact, invalidation dimensions, and health status. Multiple logistic regression analyses revealed that an increased discounting of the disease by the patient’s spouse was associated with a 4-fold increased risk for vitamin D deficiency (OR = 4.36; 95% CI, 0.95−19.87, P = 0.05). Conclusions: This study showed that although high rates of vitamin D insufficiency or deficiency were seen among FM patients and healthy non-FM participants, but it seems there was no intrinsic association between FM and vitamin D deficiency. Addressing of invalidation experience especially by the patient’s spouse is important in management of FM. (Korean J Pain 2016; 29: 172-8)
참고문헌 (28)
- Holick MF, "Vitamin D deficiency", N Engl J Med, 357, pp.266~281 (2007)
- de Rezende Pena C, "Evaluation of 25-hydroxyvitamin D serum levels in patients with fibromyalgia", J Clin Rheumatol, 16, pp.365~369 (2010)
- Straube S, "Vitamin D for the treatment of chronic painful conditions in adults", Cochrane Database Syst Rev, pp.CD007771~ (2010)
- Tandeter H, "Serum 25-OH vitamin D levels in patients with fibromyalgia", Isr Med Assoc J, 11, pp.339~342 (2009)
- Warner AE, "Diffuse musculoskeletal pain is not associated with low vitamin D levels or improved by treatment with vitamin D", J Clin Rheumatol, 14, pp.12~16 (2008)
- McBeth J, "Musculoskeletal pain is associated with very low levels of vitamin D in men : results from the European Male Ageing Study", Ann Rheum Dis, 69, pp.1448~1452 (2010)
- Heidari B, "Association between nonspecific skeletal pain and vitamin D deficiency", Int J Rheum Dis, 13, pp.340~346 (2010)
- Plotnikoff GA, "Prevalence of severe hypovitaminosis D in patients with persistent, nonspecific musculoskeletal pain", Mayo Clin Proc, 78, pp.1463~1470 (2003)
- Armstrong DJ, "Vitamin D deficiency is associated with anxiety and depression in fibromyalgia", Clin Rheumatol, 26, pp.551~554 (2007)
- Ganji V, "Serum vitamin D concentrations are related to depression in young adult US population : the Third National Health and Nutrition Examination Survey", Int Arch Med, 3, pp.29~ (2010)
- McCarty DE, "The link between vitamin D metabolism and sleep medicine", Sleep Med Rev, 18, pp.311~319 (2014)
- Schmidt-Wilcke T, "Fibromyalgia : from pathophysiology to therapy", Nat Rev Rheumatol, 7, pp.518~527 (2011)
- Edwards RR, "Duration of sleep contributes to next-day pain report in the general population", Pain, 137, pp.202~207 (2008)
- Zittermann A, "Vitamin D in preventive medicine: are we ignoring the evidence?", Br J Nutr, 89, pp.552~572 (2003)
- Kool MB, "Understanding the lack of understanding : invalidation from the perspective of the patient with fibromyalgia", Arthritis Rheum, 61, pp.1650~1656 (2009)
- Kool MB, "Social support and invalidation by others contribute uniquely to the understanding of physical and mental health of patients with rheumatic diseases", J Health Psychol, 18, pp.86~95 (2013)
- Bidari A, "Validation of the 2010 American College of Rheumatology preliminary diagnostic criteria for fibromyalgia in an Iranian population", Rheumatol Int, 33, pp.2999~3007 (2013)
- Wolfe F, "The American College of Rheumatology preliminary diagnostic criteria for fibromyalgia and measurement of symptom severity", Arthritis Care Res(Hoboken), 62, pp.600~610 (2010)
- Wolfe F, "The American College of Rheumatology 1990 criteria for the classification of fibromyalgia. Report of the multicenter criteria committee", Arthritis Rheum, 33, pp.160~172 (1990)
- Bennett RM, "The revised fibromyalgia impact questionnaire (FIQR):validation and psychometric properties", Arthritis Res Ther, 11, pp.R120~ (2009)
- Kool MB, "Lack of understanding in fibromyalgia and rheumatoid arthritis : the Illness Invalidation Inventory(3*I)", Ann Rheum Dis, 69, pp.1990~1995 (2010)
- Montazeri A, "The Iranian version of 12-item short form health survey (SF-12):factor structure, internal consistency and construct validity", BMC Public Health, 9, pp.341~ (2009)
- Ghavidel Parsa B, "The validity and reliability of the persian version of the revised fibromyalgia impact questionnaire", Rheumatol Int, 34, pp.175~180 (2014)
- Mateos F, "Bone mass and vitamin D levels in women with a diagnosis of fibromyalgia", Osteoporos Int, 25, pp.525~533 (2014)
- Wepner F, "Effects of vitamin D on patients with fibromyalgia syndrome : a randomized placebocontrolled trial", Pain, 155, pp.261~268 (2014)
- Daniel D, "Fibromyalgia--should we be testing and treating for vitamin D deficiency?", Aust Fam Physician, 40, pp.712~716 (2011)
- Straube S, "Vitamin D and chronic pain", Pain, 141, pp.10~13 (2009)
- Kool MB, "Patient and spouse appraisals of health status in rheumatoid arthritis and fibromyalgia: discrepancies and associations with invalidation", Clin Exp Rheumatol, 29, pp.S63~S69 (2011)