Herbal anti-inflammatory immunomodulators as host modulators in chronic periodontitis patients: a randomised, double-blind, placebo-controlled, clinical trial
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Purpose: Host modulatory therapy has been proposed as a treatment for periodontal diseases. A class of herbal medicines, known to be immunomodulators, alters the activity ofimmune function through the regulation of informational molecules such as cytokines. Inthe current study, we tested the hypothesis that herbal immunomodulator drugs act as anadjuvant to scaling and root planing (SRP) in alleviating periodontal inflammation by improvingclinical and biochemical parameters. Methods: Sixty healthy subjects (30 in each group) with moderate and severe chronic periodontitiswere enrolled in a double-blind, placebo-controlled, double-masked randomisedcontrolled trial. The control group was treated with SRP and a placebo, whereas the testgroup was treated with SRP followed by dietary supplementation of Septilin for 3 weeks. Periodontal clinical parameters and serum C-reactive protein (CRP) levels were evaluatedfor all patients at the baseline, 3 weeks, and 6 weeks. Results: Improved gingival index scores found in the test group as compared to the controlgroup were found to be statistically significant only after 3 weeks (P<0.001). In contrast,the decrease in the sulcus bleeding index and pocket depth scores was statistically highlysignificant in the test group as compared to the control group after 3 weeks and 6 weeks(P<0.001). However, reduced clinical attachment level and CRP scores, as reflected in thetest group as compared to the control group, were not found to be statistically significantafter both 3 weeks (P>0.05) and 6 weeks (P>0.05). Conclusions: The results of this clinical-biochemical study suggest that dietary supplementationwith herbal immunomodulatory agents may be a promising adjunct to SRP and mayaid in improving periodontal treatment outcomes.
Abstract
Purpose: Host modulatory therapy has been proposed as a treatment for periodontal diseases. A class of herbal medicines, known to be immunomodulators, alters the activity ofimmune function through the regulation of informational molecules such as cytokines. Inthe current study, we tested the hypothesis that herbal immunomodulator drugs act as anadjuvant to scaling and root planing (SRP) in alleviating periodontal inflammation by improvingclinical and biochemical parameters. Methods: Sixty healthy subjects (30 in each group) with moderate and severe chronic periodontitiswere enrolled in a double-blind, placebo-controlled, double-masked randomisedcontrolled trial. The control group was treated with SRP and a placebo, whereas the testgroup was treated with SRP followed by dietary supplementation of Septilin for 3 weeks. Periodontal clinical parameters and serum C-reactive protein (CRP) levels were evaluatedfor all patients at the baseline, 3 weeks, and 6 weeks. Results: Improved gingival index scores found in the test group as compared to the controlgroup were found to be statistically significant only after 3 weeks (P<0.001). In contrast,the decrease in the sulcus bleeding index and pocket depth scores was statistically highlysignificant in the test group as compared to the control group after 3 weeks and 6 weeks(P<0.001). However, reduced clinical attachment level and CRP scores, as reflected in thetest group as compared to the control group, were not found to be statistically significantafter both 3 weeks (P>0.05) and 6 weeks (P>0.05). Conclusions: The results of this clinical-biochemical study suggest that dietary supplementationwith herbal immunomodulatory agents may be a promising adjunct to SRP and mayaid in improving periodontal treatment outcomes.
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