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Bone formation around rhBMP-2- coated implants in rabbit sinuses with or without absorbable collagen sponge grafting

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Purpose: The purpose of this study was to evaluate bone formation around recombinanthuman bone morphogenetic protein (rhBMP-2)-coated implants placed with or withoutabsorbable collagen sponge (ACS) in rabbit maxillary sinuses. Methods: The Schneiderian membrane was elevated and an implant was placed in 24 sinusesin 12 rabbits. The space created beneath the elevated membrane was filled with eitherblood (n=6) or ACS (n=6). In the rabbits in which this space was filled with blood, rh-BMP-2-coated and non-coated implants were alternately placed on different sides. The resultinggroups were referred to as the BC and BN groups, respectively. The AC and ANgroups were produced in ACS-grafted rabbits in the same manner. Radiographic and histomorphometricanalyses were performed after eight weeks of healing. Results: In micro-computed tomography analysis, the total augmented volume and newbone volume were significantly greater in the ACS-grafted sinuses than in the blood-filledsinuses (P<0.05). The histometric analysis showed that the areas of new bone and boneto-implant contact were significantly larger in the AC group than in the AN group(P<0.05). In contrast, none of the parameters differed significantly between the BC and BNgroups. Conclusions: The results of this pilot study indicate that the insertion of ACS after elevatingthe Schneiderian membrane, simultaneously with implant placement, can significantlyincrease the volume of the augmentation. However, in the present study, the rhBMP-2coating exhibited limited effectiveness in enhancing the quantity and quality of regeneratedbone.

Abstract

Purpose: The purpose of this study was to evaluate bone formation around recombinanthuman bone morphogenetic protein (rhBMP-2)-coated implants placed with or withoutabsorbable collagen sponge (ACS) in rabbit maxillary sinuses. Methods: The Schneiderian membrane was elevated and an implant was placed in 24 sinusesin 12 rabbits. The space created beneath the elevated membrane was filled with eitherblood (n=6) or ACS (n=6). In the rabbits in which this space was filled with blood, rh-BMP-2-coated and non-coated implants were alternately placed on different sides. The resultinggroups were referred to as the BC and BN groups, respectively. The AC and ANgroups were produced in ACS-grafted rabbits in the same manner. Radiographic and histomorphometricanalyses were performed after eight weeks of healing. Results: In micro-computed tomography analysis, the total augmented volume and newbone volume were significantly greater in the ACS-grafted sinuses than in the blood-filledsinuses (P<0.05). The histometric analysis showed that the areas of new bone and boneto-implant contact were significantly larger in the AC group than in the AN group(P<0.05). In contrast, none of the parameters differed significantly between the BC and BNgroups. Conclusions: The results of this pilot study indicate that the insertion of ACS after elevatingthe Schneiderian membrane, simultaneously with implant placement, can significantlyincrease the volume of the augmentation. However, in the present study, the rhBMP-2coating exhibited limited effectiveness in enhancing the quantity and quality of regeneratedbone.

참고문헌 (34)

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관련 논문AI추천

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