Assessment of dehydrothermally cross-linked collagen membrane for guided bone regeneration around peri-implant dehiscence defects: a randomized single-blinded clinical trial
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Purpose: The aim of this study was to determine the clinical feasibility of using dehydrothermallycross-linked collagen membrane (DCM) for bone regeneration around peri-implantdehiscence defects, and compare it with non-cross-linked native collagen membrane(NCM). Methods: Dehiscence defects were investigated in twenty-eight patients. Defect width andheight were measured by periodontal probe immediately following implant placement(baseline) and 16 weeks afterward. Membrane manipulation and maintenance were clinicallyassessed by means of the visual analogue scale score at baseline. Changes in horizontalthickness at 1 mm, 2 mm, and 3 mm below the top of the implant platform and the averagebone density were assessed by cone-beam computed tomography at 16 weeks. Degradationof membrane was histologically observed in the soft tissue around the implantprior to re-entry surgery. Results: Five defect sites (two sites in the NCM group and three sites in the DCM group)showed soft-tissue dehiscence defects and membrane exposure during the early healingperiod, but there were no symptoms or signs of severe complications during the experimentalpostoperative period. Significant clinical and radiological improvements were foundin all parameters with both types of collagen membrane. Partially resorbed membrane leafletswere only observed histologically in the DCM group. Conclusions: These findings suggest that, compared with NCM, DCM has a similar clinicalexpediency and possesses more stable maintenance properties. Therefore, it could be usedeffectively in guided bone regeneration around dehiscence-type defects.
Abstract
Purpose: The aim of this study was to determine the clinical feasibility of using dehydrothermallycross-linked collagen membrane (DCM) for bone regeneration around peri-implantdehiscence defects, and compare it with non-cross-linked native collagen membrane(NCM). Methods: Dehiscence defects were investigated in twenty-eight patients. Defect width andheight were measured by periodontal probe immediately following implant placement(baseline) and 16 weeks afterward. Membrane manipulation and maintenance were clinicallyassessed by means of the visual analogue scale score at baseline. Changes in horizontalthickness at 1 mm, 2 mm, and 3 mm below the top of the implant platform and the averagebone density were assessed by cone-beam computed tomography at 16 weeks. Degradationof membrane was histologically observed in the soft tissue around the implantprior to re-entry surgery. Results: Five defect sites (two sites in the NCM group and three sites in the DCM group)showed soft-tissue dehiscence defects and membrane exposure during the early healingperiod, but there were no symptoms or signs of severe complications during the experimentalpostoperative period. Significant clinical and radiological improvements were foundin all parameters with both types of collagen membrane. Partially resorbed membrane leafletswere only observed histologically in the DCM group. Conclusions: These findings suggest that, compared with NCM, DCM has a similar clinicalexpediency and possesses more stable maintenance properties. Therefore, it could be usedeffectively in guided bone regeneration around dehiscence-type defects.
참고문헌 (35)
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