Effectiveness of porcine-derived xenograft with enamel matrix derivative for periodontal regenerative treatment of intrabony defects associated with a fixed dental prosthesis: a 2-year follow-up retrospective study
0
조회
0
다운로드
2
인용
0
참고문헌
키워드
초록
Purpose: Due to the difficulty of the hygienic care and sanitary management of abutment teeth and subpontic areas associated with fixed dental prostheses (FDPs), intrabony defects occur and accelerate due to the accumulation of plaque and calculus. This study aimed to evaluate the efficacy of regenerative periodontal surgery for intrabony defects associated with FDPs. Methods: The study inclusion criteria were met by 60 patients who underwent regenerative treatment between 2016 and 2018, involving a total of 82 intrabony defects associated with FDPs. Periodontal osseous lesions were classified as 1-, 2-, and 3-wall intrabony defects and were treated with an enamel matrix derivative in combination with bone graft material. The changes in clinical (pocket probing depth [PPD] and clinical attachment level [CAL]) and radiographic (defect depth and width) outcomes were measured at baseline and at 6, 12, and 24 months. Results: Six months after regenerative treatment, a significant reduction was observed in the PPD of 1-wall (P<0.001), 2-wall (P<0.001), and 3-wall (P<0.001) defects, as well as a significant reduction in the CAL of 2-wall (P<0.001) and 3-wall (P<0.001) intrabony defects. However, there was a significant increase in the CAL of 1-wall intrabony defects (P=0.003). Radiographically, a significant reduction in the depth of the 3-wall (P<0.001) defects and a significant reduction in the width of 2-wall (P=0.008) and 3-wall (P<0.001) defects were observed. The depth decreased in 1-wall defects; however, this change was not statistically significant (P=0.066). Conclusions: Within the limitations of the current study, regenerative treatment of 2- and 3-wall intrabony defects associated with FDPs improved clinical and radiological outcomes. Additional prospective studies are necessary to confirm our findings and to assess long-term outcomes.
Abstract
Purpose: Due to the difficulty of the hygienic care and sanitary management of abutment teeth and subpontic areas associated with fixed dental prostheses (FDPs), intrabony defects occur and accelerate due to the accumulation of plaque and calculus. This study aimed to evaluate the efficacy of regenerative periodontal surgery for intrabony defects associated with FDPs. Methods: The study inclusion criteria were met by 60 patients who underwent regenerative treatment between 2016 and 2018, involving a total of 82 intrabony defects associated with FDPs. Periodontal osseous lesions were classified as 1-, 2-, and 3-wall intrabony defects and were treated with an enamel matrix derivative in combination with bone graft material. The changes in clinical (pocket probing depth [PPD] and clinical attachment level [CAL]) and radiographic (defect depth and width) outcomes were measured at baseline and at 6, 12, and 24 months. Results: Six months after regenerative treatment, a significant reduction was observed in the PPD of 1-wall (P<0.001), 2-wall (P<0.001), and 3-wall (P<0.001) defects, as well as a significant reduction in the CAL of 2-wall (P<0.001) and 3-wall (P<0.001) intrabony defects. However, there was a significant increase in the CAL of 1-wall intrabony defects (P=0.003). Radiographically, a significant reduction in the depth of the 3-wall (P<0.001) defects and a significant reduction in the width of 2-wall (P=0.008) and 3-wall (P<0.001) defects were observed. The depth decreased in 1-wall defects; however, this change was not statistically significant (P=0.066). Conclusions: Within the limitations of the current study, regenerative treatment of 2- and 3-wall intrabony defects associated with FDPs improved clinical and radiological outcomes. Additional prospective studies are necessary to confirm our findings and to assess long-term outcomes.
참고문헌 (28)
- Tan K, "A systematic review of the survival and complication rates of fixed partial dentures(FPDs)after an observation period of at least 5 years", Clin Oral Implants Res, 15, pp.654~666 (2004)
- Hochman N, "Splinting : a retrospective 17-year follow-up study", J Prosthet Dent, 67, pp.600~602 (1992)
- Fayyad MA, "Failure of dental bridges : III--effect of some technical factors", J Oral Rehabil, 23, pp.675~678 (1996)
- Fayyad MA, "Failure of dental bridges. II. Prevalence of failure and its relation to place of construction", J Oral Rehabil, 23, pp.438~440 (1996)
- Knoernschild KL, "Periodontal tissue responses after insertion of artificial crowns and fixed partial dentures", J Prosthet Dent, 84, pp.492~498 (2000)
- Freilich MA, "Periodontal effects of fixed partial denture retainer margins : configuration and location", J Prosthet Dent, 67, pp.184~190 (1992)
- Valderhaug J, "Oral hygiene, periodontal conditions and carious lesions in patients treated with dental bridges. A 15-year clinical and radiographic follow-up study", J Clin Periodontol, 20, pp.482~489 (1993)
- Müller HP, "The effect of artificial crown margins at the gingival margin on the periodontal conditions in a group of periodontally supervised patients treated with fixed bridges", J Clin Periodontol, 13, pp.97~102 (1986)
- Valderhaug J, "Periodontal conditions in patients 5 years following insertion of fixed prostheses. Pocket depth and loss of attachment", J Oral Rehabil, 3, pp.237~243 (1976)
- Meyle J, "Molecular aspects of the pathogenesis of periodontitis", Periodontol 2000, 69, pp.7~17 (2015)
- Papapanou PN, "Diagnosis and epidemiology of periodontal osseous lesions", Periodontol 2000, 22, pp.8~21 (2000)
- Reynolds MA, "Periodontal regeneration -intrabony defects: a consensus report from the AAP regeneration workshop", J Periodontol, 86, pp.S105~107 (2015)
- Blumenthal NM, "Defect-determined regenerative options for treating periodontal intrabony defects in baboons", J Periodontol, 74, pp.10~24 (2003)
- Díaz-Faes L, "Efficacy of regenerative therapy in aggressive periodontitis : a systematic review and meta-analysis of randomised controlled clinical trials", Clin Oral Investig, 24, pp.1369~1378 (2020)
- Barbato L, "Clinical efficacy of minimally invasive surgical (MIS) and non-surgical (MINST) treatments of periodontal intra-bony defect. A systematic review and network meta-analysis of RCT's", Clin Oral Investig, 24, pp.1125~1135 (2020)
- Lee JH, "Assessment of early discomfort and wound healing outcomes after periodontal surgery with and without enamel matrix derivative : an observational retrospective case-control study", Clin Oral Investig, 24, pp.229~237 (2020)
- Lee JH, "Adjunctive use of enamel matrix derivatives to porcine-derived xenograft for the treatment of one-wall intrabony defects : two-year longitudinal results of a randomized controlled clinical trial", J Periodontol, 91, pp.880~889 (2020)
- Needleman I, "A systematic review of guided tissue regeneration for periodontal infrabony defects", J Periodontal Res, 37, pp.380~388 (2002)
- Murphy KG, "Guided tissue regeneration for the treatment of periodontal intrabony and furcation defects. A systematic review", Ann Periodontol, 8, pp.266~302 (2003)
- Needleman IG, "Guided tissue regeneration for periodontal infra-bony defects", Cochrane Database Syst Rev, pp.CD001724~ (2006)
- Reynolds MA, "The efficacy of bone replacement grafts in the treatment of periodontal osseous defects. A systematic review", Ann Periodontol, 8, pp.227~265 (2003)
- Lee JH, "Comparative assessment of anterior maxillary alveolar ridge preservation with and without adjunctive use of enamel matrix derivative : A randomized clinical trial", Clin Oral Implants Res, 31, pp.1~9 (2020)
- Li W, "The use of enamel matrix derivative alone versus in combination with bone grafts to treat patients with periodontal intrabony defects : a meta-analysis", J Am Dent Assoc, 143, pp.e46~56 (2012)
- Matarasso M, "Enamel matrix derivative and bone grafts for periodontal regeneration of intrabony defects. A systematic review and meta-analysis", Clin Oral Investig, 19, pp.1581~1593 (2015)
- Nemoto Y, "Clinical and CBCT evaluation of combined periodontal regenerative therapies using enamel matrix derivative and deproteinized bovine bone mineral with or without collagen membrane", Int J Periodontics Restorative Dent, 38, pp.373~381 (2018)
- Kubota T, "A comparable study of combinational regenerative therapies comprising enamel matrix derivative plus deproteinized bovine bone mineral with or without collagen membrane in periodontitis patients with intrabony defects", Open J Stomatol, 8, pp.277~286 (2018)
- Lekovic V, "A comparison between enamel matrix proteins used alone or in combination with bovine porous bone mineral in the treatment of intrabony periodontal defects in humans", J Periodontol, 71, pp.1110~1116 (2000)
- Zucchelli G, "Enamel matrix proteins and bovine porous bone mineral in the treatment of intrabony defects : a comparative controlled clinical trial", J Periodontol, 74, pp.1725~1735 (2003)