Soft-tissue volume augmentation using a connective tissue graft and a volume-stable collagen matrix with polydeoxyribonucleotide for immediate implant placement: a pilot study in a dog model
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Purpose: The aims of this study were 1) to investigate the effects of a subepithelial connective tissue graft (SCTG) and a volume-stable collagen matrix (VCMX) on soft-tissue volume gain in the immediate implant placement protocol, and 2) to determine whether polydeoxyribonucleotide (PDRN) can enhance the effects of a VCMX. Methods: Dental implants were placed in 4 mongrel dogs immediately after extracting the distal roots of their third and fourth mandibular premolars. The gap between the implant and the buccal bone plate was filled with synthetic bone substitute particles. The following soft-tissue augmentation modalities were applied buccally: 1) control (no augmentation), 2) SCTG, 3) VCMX, and 4) VCMX/PDRN. After 4 months, histomorphometric analysis was performed. Tissue changes were evaluated using superimposed standard tessellation language (STL) files. Results: Wound dehiscence was found in more than half of the test groups, but secondary wound healing was successfully achieved in all groups. Histomorphometrically, tissue thickness was favored in group SCTG at or above the implant platform level (IP), and group SCTG and the groups with VCMX presented similar tissue thickness below the IP. However, the differences in such thickness among the groups were minor. The keratinized tissue height was greater in group VCMX/PDRN than in groups SCTG and VCMX. Superimposing the STL f iles revealed a decrease in soft-tissue volume in all groups. Conclusions: Wound dehiscence after soft-tissue volume augmentation might be detrimental to obtaining the expected outcomes. PDRN appears not to have a positive effect on the soft tissue volume gain.
Abstract
Purpose: The aims of this study were 1) to investigate the effects of a subepithelial connective tissue graft (SCTG) and a volume-stable collagen matrix (VCMX) on soft-tissue volume gain in the immediate implant placement protocol, and 2) to determine whether polydeoxyribonucleotide (PDRN) can enhance the effects of a VCMX. Methods: Dental implants were placed in 4 mongrel dogs immediately after extracting the distal roots of their third and fourth mandibular premolars. The gap between the implant and the buccal bone plate was filled with synthetic bone substitute particles. The following soft-tissue augmentation modalities were applied buccally: 1) control (no augmentation), 2) SCTG, 3) VCMX, and 4) VCMX/PDRN. After 4 months, histomorphometric analysis was performed. Tissue changes were evaluated using superimposed standard tessellation language (STL) files. Results: Wound dehiscence was found in more than half of the test groups, but secondary wound healing was successfully achieved in all groups. Histomorphometrically, tissue thickness was favored in group SCTG at or above the implant platform level (IP), and group SCTG and the groups with VCMX presented similar tissue thickness below the IP. However, the differences in such thickness among the groups were minor. The keratinized tissue height was greater in group VCMX/PDRN than in groups SCTG and VCMX. Superimposing the STL f iles revealed a decrease in soft-tissue volume in all groups. Conclusions: Wound dehiscence after soft-tissue volume augmentation might be detrimental to obtaining the expected outcomes. PDRN appears not to have a positive effect on the soft tissue volume gain.
참고문헌 (40)
- Araújo MG, "Dimensional ridge alterations following tooth extraction. An experimental study in the dog", J Clin Periodontol, 32, pp.212~218 (2005)
- Tan WL, "A systematic review of post-extractional alveolar hard and soft tissue dimensional changes in humans", Clin Oral Implants Res, 23(Suppl 5), pp.1~21 (2012)
- Pommer B, "Scientific interests of 21st century clinical oral implant research : topical trend analysis", Clin Implant Dent Relat Res, 18, pp.850~856 (2016)
- Botticelli D, "Hard-tissue alterations following immediate implant placement in extraction sites", J Clin Periodontol, 31, pp.820~828 (2004)
- Araújo MG, "Bio-Oss collagen in the buccal gap at immediate implants : a 6-month study in the dog", Clin Oral Implants Res, 22, pp.1~8 (2011)
- Chen ST, "Immediate or early placement of implants following tooth extraction : review of biologic basis, clinical procedures, and outcomes", Int J Oral Maxillofac Implants, 19(Suppl), pp.12~25 (2004)
- Kan JY, "Facial gingival tissue stability following immediate placement and provisionalization of maxillary anterior single implants : a 2-to 8-year follow-up", Int J Oral Maxillofac Implants, 26, pp.179~187 (2011)
- Lim HC, "Immediate implant placement in conjunction with guided bone regeneration and", or connective tissue grafts : an experimental study in canines, 2022, pp.52, 170~180
- Bianchi AE, "Single-tooth replacement by immediate implant and connective tissue graft : a 1–9-year clinical evaluation", Clin Oral Implants Res, 15, pp.269~277 (2004)
- Covani U, "Bucco-lingual crestal bone changes after immediate and delayed implant placement", J Periodontol, 75, pp.1605~1612 (2004)
- Chen ST, "Esthetic outcomes following immediate and early implant placement in the anterior maxilla--a systematic review", Int J Oral Maxillofac Implants, 29(Suppl), pp.186~215 (2014)
- Cosyn J, "A systematic review on the frequency of advanced recession following single immediate implant treatment", J Clin Periodontol, 39, pp.582~589 (2012)
- Cosyn J, "A 5-year prospective study on single immediate implants in the aesthetic zone", J Clin Periodontol, 43, pp.702~709 (2016)
- Hosseini M, "Tissue changes at implant sites in the anterior maxilla with and without connective tissue grafting : a five-year prospective study", Clin Oral Implants Res, 31, pp.18~28 (2020)
- Levine RA, "10 Keys for successful esthetic-zone single implants : importance of biotype conversion for lasting success", Compend Contin Educ Dent, 39, pp.522~529 (2018)
- Thoma DS, "Efficacy of soft tissue augmentation around dental implants and in partially edentulous areas : a systematic review", J Clin Periodontol, 41(Suppl 15), pp.S77~S91 (2014)
- Thoma DS, "A systematic review assessing soft tissue augmentation techniques", Clin Oral Implants Res, 20(Suppl 4), pp.146~165 (2009)
- Thoma DS, "Randomized controlled clinical study evaluating effectiveness and safety of a volume-stable collagen matrix compared to autogenous connective tissue grafts for soft tissue augmentation at implant sites", J Clin Periodontol, 43, pp.874~885 (2016)
- Thoma DS, "Soft tissue volume augmentation at dental implant sites using a volume stable three-dimensional collagen matrix-histological outcomes of a preclinical study", J Clin Periodontol, 44, pp.185~194 (2017)
- Naenni N, "Volumetric and linear changes at dental implants following grafting with volume-stable three-dimensional collagen matrices or autogenous connective tissue grafts : 6-month data", Clin Oral Investig, 22, pp.1185~1195 (2018)
- Cosyn J, "EAO position paper : immediate implant placement : managing hard and soft tissue stability from diagnosis to prosthetic treatment", Int J Prosthodont, 36, pp.533~545 (2023)
- Hämmerle CH, "Efficacy of a collagen matrix for soft tissue augmentation after implant placement compared to connective tissue grafts : a multicenter, noninferiority, randomized controlled trial", Clin Oral Implants Res, 34, pp.999~1013 (2023)
- Squadrito F, "Pharmacological activity and clinical use of PDRN", Front Pharmacol, 8, pp.224~ (2017)
- Bitto A, "Polydeoxyribonucleotide improves angiogenesis and wound healing in experimental thermal injury", Crit Care Med, 36, pp.1594~1602 (2008)
- Galeano M, "Polydeoxyribonucleotide stimulates angiogenesis and wound healing in the genetically diabetic mouse", Wound Repair Regen, 16, pp.208~217 (2008)
- Lee DW, "The effect of polydeoxyribonucleotide on ischemic rat skin flap survival", Ann Plast Surg, 75, pp.84~90 (2015)
- Shin SM, "Polydeoxyribonucleotide exerts opposing effects on ERK activity in human skin keratinocytes and fibroblasts", Mol Med Rep, 28, pp.148~ (2023)
- Lee KS, "Dimensional ridge changes in conjunction with four implant timing protocols and two types of soft tissue grafts : a pilot pre-clinical study", J Clin Periodontol, 49, pp.401~411 (2022)
- Lim HC, "Effect of polydeoxyribonucleotide with xenogeneic collagen matrix on gingival phenotype modification : a pilot preclinical study", J Periodontal Implant Sci, 53, pp.417~428 (2023)
- Kilkenny C, "Animal research : reporting in vivo experiments : the ARRIVE guidelines", Br J Pharmacol, 160, pp.1577~1579 (2010)
- Caneva M, "Connective tissue grafts in conjunction with implants installed immediately into extraction sockets. An experimental study in dogs", Clin Oral Implants Res, 24, pp.50~56 (2013)
- Thoma DS, "Soft tissue volume augmentation by the use of collagen-based matrices in the dog mandible--a histological analysis", J Clin Periodontol, 38, pp.1063~1070 (2011)
- Aldhohrah T, "Does simultaneous soft tissue augmentation around immediate or delayed dental implant placement using sub-epithelial connective tissue graft provide better outcomes compared to other treatment options? A systematic review and meta-analysis", PLoS One, 17, pp.e0261513~ (2022)
- De Angelis P, "The effect of soft tissue augmentation on the clinical and radiographical outcomes following immediate implant placement and provisionalization : a systematic review and meta-analysis", Int J Implant Dent, 7, pp.86~ (2021)
- Raghoebar GM, "Linear and profilometric changes of the mucosa following soft tissue augmentation in the zone of aesthetic priority : a systematic review and meta-analysis", Clin Oral Implants Res, 32(Suppl 21), pp.138~156 (2021)
- Seyssens L, "Immediate implant placement with or without connective tissue graft : a systematic review and meta-analysis", J Clin Periodontol, 48, pp.284~301 (2021)
- Linkevicius T, "Influence of titanium base, lithium disilicate restoration and vertical soft tissue thickness on bone stability around triangular-shaped implants : a prospective clinical trial", Clin Oral Implants Res, 29, pp.716~724 (2018)
- Cosyn J, "A multi-centre randomized controlled trial comparing connective tissue graft with collagen matrix to increase soft tissue thickness at the buccal aspect of single implants : 1-year results", J Clin Periodontol, 49, pp.911~921 (2022)
- Zeltner M, "Randomized controlled clinical study comparing a volume-stable collagen matrix to autogenous connective tissue grafts for soft tissue augmentation at implant sites : linear volumetric soft tissue changes up to 3 months", J Clin Periodontol, 44, pp.446~453 (2017)
- Becker J, "Use of a new cross-linked collagen membrane for the treatment of dehiscence-type defects at titanium implants : a prospective, randomized-controlled double-blinded clinical multicenter study", Clin Oral Implants Res, 20, pp.742~749 (2009)