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췌장관샘암종에서 Matrix Metalloproteinase-2 (MMP-2)와 Tissue Inhibitor of Metalloproteinase-2 (TIMP-2)의 발현

Expression of Matrix Metalloproteinase-2 (MMP-2) and Tissue Inhibitor of Metalloproteinase-2 (TIMP-2) in Pancreatic Ductal Adenocarcinoma

최준혁|배영경|구미진
대한병리학회|2004.04|Journal of Pathology and Translational Medicine|제38권 제2호|pp. 73-78

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참고문헌

주제분류병리학

초록

Abstract

Background : Matrix metalloproteinase-2 (MMP-2) is known to be one of the key molecules for tumor invasion and metastasis. MMP-2 activity is modulated through interaction with the tissue inhibitor of metalloproteinase-2 (TIMP-2). The purpose of this study was to evaluate the expression of MMP-2 and TIMP-2 in pancreatic ductal adenocarcinoma. Methods : Using immunohistochemical staining, we investigated the expression of MMP-2 and TIMP-2 in 30 pancreatic ductal adenocarcinomas and 10 normal pancreas. Results : MMP-2 expression was present in tumor cells in 11 cases, and in stromal cells in 24 cases, out of 30 carcinomas. MMP-2 expression of tumor cells was significantly higher in poorly differentiated adenocarcinomas than in well/moderately differentiated adenocarcinomas, and in cases with vascular invasion than in cases without. MMP-2 expression was stronger in the marginal areas than in the central area of the tumor. TIMP-2 expression was detected in the tumor and stromal cells of all carcinomas. MMP-2 and TIMP-2 expression had no significant correlation with tumor size, lymph node metastasis, or TNM stage. MMP-2 expression was not correlated with TIMP-2 expression. Conclusions : These results suggest that MMP-2 expression may play an important role in the invasive property of pancreatic ductal adenocarcinoma, whereas TIMP-2 expression increases as a reaction to invasion.

참고문헌 (30)

  1. "Imbalanceof expression of matrix metalloproteinase and tissue inhi-bitors of the matrix metalloproteinases(TIMPs)in human pancreaticcarcinoma", 182, pp.347~355 (1997)
  2. "Involvement of matrix metal-loproteinase-2 activity in invasion and metastasis of pancreatic car-cinoma", 82, pp.642~650 (1988)
  3. "Expression of matrix metallopro-teinase and tissue inhibitors of metalloproteinases in human pancre-atic adenocarcinomas:clinicopathologic and prognostic significanceof matrilysin expression", 19, pp.1118~1127 (2001)
  4. "Invasiveness and MMP expression in pancreatic carcinoma", 98, pp.33~39 (2001)
  5. "Tumor invasion and extracellularmatrix.", pp.636~49
  6. "Expression of matrix met-alloproteinase and the tissue inhibitors of metalloproteinases andtheir local invasiveness and metastasis in Chinese human pancreat-ic cancer", 73, pp.95~99 (2000)
  7. "Role of MT-MMPs and MMP-2 in pancreatic cancer progression", 85, pp.14~20 (2000)
  8. "Correlation between expression of matrix metal-loproteinase-2 and angiogenesis in colorectal adenocarcinoma", pp.263~270 (1999)
  9. "Stromal expres-sion of 72 kda type IV collagenase", pp.389~2 96, and TIMP-2 mRNAs incolorectal neoplasia
  10. "Immunohistochemical distribution of type IV collagenase in", pp.585~92
  11. "Expression of membrane-type matrix metalloproteinase in human gastric carcinomas", 55, pp.3263~3236 (1995)
  12. "Expression of matrix metalloproteinase and its inhibitor ingastric adenocarcinoma", 33, pp.199~206 (2001)
  13. "Overexpression of MMP-9correlates with growth of small hepatocellular carcinoma", 17, pp.237~243 (2000)
  14. "Levels of matrix metalloproteinasein bladder cancer correlate with tumor grade and invasion", pp.5365~5369 (1993)
  15. "Increased expressionof matrix metalloproteinase 7 and 9 and membrane type 1-matrixmetalloproteinase in esophageal squamous cell carcinomas", 88, pp.2201~2209 (2000)
  16. "Detection of matrix metalloproteinaseactivity in human pancreatic cancer", 27, pp.302~304 (1997)
  17. "Expressionof the MMP-1 in human pancreatic carcinoma relationship with prognosticfactor", 12, pp.669~674 (1999)
  18. "Inhibition of invasion and metastasis in cells transfected withan inhibitor of metalloproteinases", 52, pp.701~708 (1992)
  19. "Histologicfeatures of venous invasion expression of vascular endothelial growthfactor and matrix metalloproteinase-2 and matrix metalloproteinase-9 and relation with liver metastasis in pancreatic cancer", 24, pp.169~178 (2002)
  20. "Autio-Harmainen H. Differential expressionof matrix metalloproteinase (MMP)-2, MMP-9,and Membranetype 1-MMP in hepatocellular and pancreatic adenocarcinoma:implicationsfor tumor progression and clinical prognosis", 6, pp.2726~2734 (2000)
  21. "Activity of type IV collagenasesin benign and malignant breast disease", 67, pp.1126~1131 (1993)
  22. "Differentialexpression of matrix metalloproteinases and their inhibitors in nonsmallcell lung cancer", 190, pp.150~156 (2000)
  23. "Expression of matrixmetalloproteinase (MMP)-2, MMP-9, tissue inhibitor of metalloproteinase (TIMP)--1 and TIMP-2 in adenocarcinomas of the gallbladder", 37, pp.1~9 (2003)
  24. "Relative expression E-cadherinand type IV collagenase genes predicts disease outcome in patientswith resectable pancreatic carcinoma", 5, pp.25~33 (1999)
  25. "Immunohistochemicallocalization of the matrix metalloproteinase 2 and its specific inhibitorTIMP-2 in neoplastic tissues with monoclonal antibodies", 56, pp.500~505 (1994)
  26. "Matrix metalloproteinases in tumor invasionand metastasis", 189, pp.300~308 (1999)
  27. "High levels of mRNA for tissue inhibitors of metalloproteinases(TIMP-1 and TIMP-2) in primary breast carcinomas are associatedwith development of metastases", pp.1623~1628 (1997)
  28. "Enhanced expressionof tissue inhibitor of metalloproteinase-2 in the stroma ofbreast carcinomas correlates with tumor recurrence", 59, pp.339~344 (1994)
  29. "Cell surface activation of progelatinase A (proMMP-2)and cell migration.", 8, pp.179~186 (1998)
  30. "Comparison of matrix metalloproteinaseexpression between primary tumors with or without livermetastasis in pancreatic and colorectal carcinomas", 80, pp.105~110 (2002)

관련 논문AI추천

담낭 샘암종에서 Matrix Metalloproteinase (MMP)-2, MMP-9, Tissue Inhibitor of Metalloproteinase (TIMP)-1, TIMP-2의 발현박영년, 박찬일, 배종엽, 정현철, 최진섭대한병리학회 · Journal of Pathology and Translational Medicine2003 · 제37권 제1호유방암종에서 MMp-2, MTI-MMP, TIMP-2 mRNA의 발현김동원, 이동화, 진소영대한병리학회 · Journal of Pathology and Translational Medicine2003 · 제37권 제6호유방암종의 MMP-2와 MMP-9 발현과 예후 인자와의 연관성박설미, 윤혜경대한병리학회 · Journal of Pathology and Translational Medicine2004 · 제38권 제2호담낭암종에서 Urokinase-Type Plasminogen Activator와 Plasminogen Activator Inhibitor-1의 발현강행지, 박문향, 이기형, 이승연대한병리학회 · Journal of Pathology and Translational Medicine2003 · 제37권 제6호췌장관 샘암종에서 c-erbB-2와 Cyclooxygenase-2의 면역조직화학적 발현김홍진, 윤성수, 최준혁, 최혜정대한병리학회 · Journal of Pathology and Translational Medicine2007 · 제41권 제3호혀의 편평상피세포암에서 MMP-2, MMP-3, MMP-10, MMP-13의 발현 양상김영실, 윤경인, 이철원, 표성운대한구강악안면외과학회 · 대한구강악안면외과학회지2002 · 제28권 제3호

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