곧창자 샘암종에서 p53, bcl-2, Ki-67 발현과 세포자멸사에 대한 연구: 수술 전 방사선화학 치료 반응과의 상관관계
An Analysis of p53, bcl-2 and Ki-67 Expressions, and Apoptosis in Rectal Cancer: Their Correlation with the Tumor Response after Preoperative Radiochemotherapy
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Abstract
Background : Preoperative radiochemotherapy (RCT) has been administered for locally advanced rectal cancer to increase the therapeutic benefits, and to preserve the sphincter in lowlying tumors, however, tumor responses after RCT are variable. Methods : Apoptotic index (AI), and expressions of Ki-67, p53 and bcl-2 were analyzed in pretreatment biopsies from 69 patients with rectal cancer by immunohistochemistry. Tumor response was graded in surgically resected specimens by using a three-scale grading system: no response (NR), partial remission (PR) and complete remission (CR). Results : CR was identified in 19 cases (28%), PR in 24 cases (35%), and NR in 26 cases (38%) of 69 cases. p53 protein was expressed in 49 cases (71%), whereas bcl-2 was in 42 cases (61%). The pretreatment Ki-67 labeling index was 65.4±23.4%. The tumor response was not associated with any of these markers. Tumors with CR/PR showed a higher AI (0.84±0.84%/0.66±0.52%) than that of tumors with NR (0.58 ±0.54%). There was a significant correlation between tumor response and the histologic differentiation (p=0.008) or recurrence (p=0.039). Conclusions : The AI revealed a tendency to increase in tumors with CR/PR, while expressions of p53 and bcl-2, and Ki-67 labeling index had little direct association with tumor response.
참고문헌 (31)
- "Colorectal cancer screening", 55, pp.35~42 (2000)
- "Annual Report of Tumor Registry in Korea Department of Health andWelfare", pp.1~2002
- "Genetic alterations in the adenoma-carcinoma sequence", 70(6), pp.1727~31 (1992)
- "Local excision of rectal cancer without adjuvant therapy:a word of caution", 231, pp.345~51 (2000)
- "Disease free survival and recurrence after resection of colorectal carcinoma", 16, pp.333~41 (1981)
- "Patterns of recurrence after curative resection of carcinoma of the colon and rectum", 174, pp.27~32 (1992)
- "Results of adjuvant radiation therapy in cancer of the rectum", 55, pp.350~3 (1985)
- "Radiotherapy,concomitant protracted-venous infusion 5-fluorouracil,and surgery of ultrasound-staged T3 or T4 rectal cancer", 44, pp.52~8 (2001)
- "T-level downstaging and complete pathologic response after preoperative chemoradiation for advanced rectal cancer result in decreased recurrence and improved disease-free survival", 45, pp.895~903 (2002)
- "Neoadjuvant therapy for adenocarcinoma of the rectum:tumor response and acute toxicity", 44, pp.513~22 (2001)
- "Changes in tumor proliferation of rectal cancer induced by preoperative 5-Fluorouracil and irradiation", 41, pp.62~7 (1998)
- "Apoptosis as a cellular predictor for histopathologic response to neoadjuvant radiochemotherapy in patients with rectal cancer", 52, pp.294~303 (2002)
- "Reporting results of cancer treatment", 47, pp.207~14 (1981)
- "Stockholm Colorectal Cancer Study Group", 3, pp.423~30
- "Enhancement of mammalian cell killing by 5-fluorouracil in combination with X-rays", 39, pp.3763~7 (1979)
- "Downstaging of advanced rectal cancer following combined preoperative chemotherapy and high dose radiation", 30, pp.169~75 (1994)
- "Pre-operative combined 5-FU low dose leucovorin,and sequential radiation therapy for unresectable rectal cancer", 25, pp.821~7 (1993)
- "Combined preoperative radiation and mitomycin", 5-fluorouracil treatment for locally advanced rectal adenocarcinoma, 1998, pp.187, 164~70
- "Preoperative radiation and chemotherapy in the treatment of adenocarcinoma of the rectum", 221, pp.778~87 (1995)
- "Prognostic markers in rectal carcinoma", 15, pp.131~40 (1998)
- "p53 is required for radiation-induced apoptosis in mouse thymocytes", 362, pp.847~9 (1993)
- "p53 mutation does not correlate with radiosensitivity in 24 head and neck cancer cell lines", 53, pp.3667~9 (1993)
- "bcl-2 protein in non-small-cell lung cancinoma", 329, pp.690~4 (1993)
- "bcl-2 and p53 oncoprotein expression during colorectal tumorigenesis", 55, pp.237~41 (1995)
- "bcl-2 and p53 status prior to and after preoperative radiochemotherapy for locally advanced rectalcancer", 41, pp.585~91
- "High intrinsic apoptosis,but not radiation-induced apoptosis,predicts better survival in rectal carcinoma patients", 57, pp.434~43 (2003)
- "Programmed cell death and radioresistance", 15, pp.119~31 (1996)
- "Gamma-radiation-induced apoptosis in human colorectal adenoma and carcinoma cell lines can occur in the absence of wild type p53", 10, pp.2391~6 (1995)
- "Role of p53 and p21", WAF1 detection in patient selection for preoperative radiotherapy in rectal cancer patients, 1998, pp.41, 68~74
- "Bcl-2 family proteins", 17, pp.3225~36 (1998)
- "Bcl-2 family proteins", 17, pp.3225~36 (1998)
