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곧창자 샘암종에서 p53, bcl-2, Ki-67 발현과 세포자멸사에 대한 연구: 수술 전 방사선화학 치료 반응과의 상관관계

An Analysis of p53, bcl-2 and Ki-67 Expressions, and Apoptosis in Rectal Cancer: Their Correlation with the Tumor Response after Preoperative Radiochemotherapy

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참고문헌

주제분류병리학

초록

Abstract

Background : Preoperative radiochemotherapy (RCT) has been administered for locally advanced rectal cancer to increase the therapeutic benefits, and to preserve the sphincter in lowlying tumors, however, tumor responses after RCT are variable. Methods : Apoptotic index (AI), and expressions of Ki-67, p53 and bcl-2 were analyzed in pretreatment biopsies from 69 patients with rectal cancer by immunohistochemistry. Tumor response was graded in surgically resected specimens by using a three-scale grading system: no response (NR), partial remission (PR) and complete remission (CR). Results : CR was identified in 19 cases (28%), PR in 24 cases (35%), and NR in 26 cases (38%) of 69 cases. p53 protein was expressed in 49 cases (71%), whereas bcl-2 was in 42 cases (61%). The pretreatment Ki-67 labeling index was 65.4±23.4%. The tumor response was not associated with any of these markers. Tumors with CR/PR showed a higher AI (0.84±0.84%/0.66±0.52%) than that of tumors with NR (0.58 ±0.54%). There was a significant correlation between tumor response and the histologic differentiation (p=0.008) or recurrence (p=0.039). Conclusions : The AI revealed a tendency to increase in tumors with CR/PR, while expressions of p53 and bcl-2, and Ki-67 labeling index had little direct association with tumor response.

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관련 논문AI추천

곧창자 샘암종에서 세포주기 조절 단백 발현:수술 전 방사선화학 치료 반응 및 예후에 미치는 영향강석진, 강창석, 신정하, 유진영, 이교영, 정지한, 최현주대한병리학회 · Journal of Pathology and Translational Medicine2006 · 제40권 제3호잘룩창자곧창자 샘암종에서 p21 단백, p53 단백, Ki-67 단백의 발현 및 세포자멸사박영의, 손진희, 신형식, 최경찬, 최영희대한병리학회 · Journal of Pathology and Translational Medicine2002 · 제36권 제5호곧창자 샘암종에서 EGFR 과발현과 수술 전 방사선화학치료 반응강석진, 유진영, 이교영, 정주원, 정지한, 최현주대한병리학회 · Journal of Pathology and Translational Medicine2007 · 제41권 제5호간내 담관암종에서의 p53, Rb, bcl-2 단백 발현과 Ki-67 표지지수와의 상관관계구미진, 김홍진, 윤성수, 최준혁대한병리학회 · Journal of Pathology and Translational Medicine2003 · 제37권 제3호조기 위암에서 림프절 전이와 p53, Bcl-2 단백 발현 및 Ki-67 표지지수의 상관관계심영란, 최준혁대한병리학회 · Journal of Pathology and Translational Medicine2002 · 제36권 제1호대장암에서 M30 면역 염색으로 검출된 세포 자멸사와 MSI및 임상 병리학적 특징과의 상관 관계강현정, 김지연, 김활웅, 박도윤, 설미영, 신동훈, 이수한, 이창훈, 최경운, 허기영대한병리학회 · Journal of Pathology and Translational Medicine2006 · 제40권 제5호

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