본문 바로가기
KERD
논문KCI 등재

인체 유방암종에서 p34cdc2, p27Kip1, p21WAF1/Cip1 및 p53의 발현

Expression of p34cdc2, p27Kip1, p21WAF1/Cip1 and p53 in Human Breast Cancers

김은경|이호정|이원미|주종은|박찬금|김동훈
대한병리학회|2005.12|Journal of Pathology and Translational Medicine|제39권 제6호|pp. 391-400

1

조회

0

다운로드

1

인용

0

참고문헌

주제분류병리학

초록

Abstract

Background : Cell cycle progression is governed by cell cycle regulators and inhibitors such as the cyclin dependent kinases (CDK), p27Kip1, p21WAF1/Cip1 and p53. The purpose of this study was to correlate expressions of p34cdc2, p27Kip1, p21WAF1/Cip1 and p53 with the various clinicopathologic prognostic parameters of human breast cancers. Methods : The paraffin-embedded tissue sections from 102 patients with human breast carcinomas were examined by performing immunohistochemical staining. The primary antibodies used for immunohistochemical staining were mouse monoclonal antibody to human p34cdc2, p27Kip1, p21WAF1/Cip1, p53, ER and PR. Results : The expression rates of p34cdc2, p21WAF1/Cip1 and p53 were 29.3%, 40.2% and 49.1% in breast carcinomas, respectively. In normal breast tissues, p34cdc2, p21WAF1/Cip1 and p53 were not expressed. The p34cdc2 was expressed in the cytoplasm of cancer cells. The expression rate of p27Kip1 was 29.3% in breast carcinomas and 100% in normal breast tissues, so the loss of p27Kip1 expression in breast cancer was noted. The high expression of p21WAF1/Cip1 in neoplastic cells was associated with the p53 expression (p=0.03). The expression of p27Kip1 was correlated with that of the progesterone receptor (PR) (p=0.04) and the expression of p21WAF1/Cip1 was correlated with that of positivity for estrogen receptor (ER) (p=0.04) and PR (p=0.04). No correlation was demonstrated between the mean patient survival and the expression rate of p34cdc2, p27Kip1, p21 WAF1/Cip1 and p53. Conclusions : The loss of the normal cell growth cycle by the abnormal expression of cyclin dependent kinases and their inhibitors and the steroid hormones may play an important role in human breast carcinogenesis. The p53 dependent p21WAF1/Cip1 pathway, the p27Kip1 protein loss and the cdc2 overexpression were important in development and progression of human breast cancer.

참고문헌 (26)

  1. "Expression of p27Kip1 protein in colorectal adenocarcinoma", 34, pp.132~7 (2000)
  2. "High level expression of p27 and cyclin D1 in some human breast cancer cells Inverse correlation between the expression of p27 and degree of malignancy in human breast and colorectal cancers", pp.6380~5
  3. "Abnormal cell cycle regulation in malignancy", 112, pp.~52 (1999)
  4. "Localization of the CDKN4", p27Kip1 gene to human chromosome 12p12, 1995, pp.96, 668~70
  5. "The p21Cdk-interacting protein Cip1 is a potent inhibitor of G1 cyclin-dependent kinases", 75, pp.805~16 (1993)
  6. "Cancer", 362, pp.786~7 (1993)
  7. "p53 mutation andexpression of Rb protein in germ cell tumors", 32, pp.1074~80 (1998)
  8. "p53 expression and prognosis in gastric carcinoma", 50, pp.859~62 (1992)
  9. "Pathological prognostic factors in breast cancer The value of histological grade in breast cancer experience froma large study with long-term follow-up", pp.403~10
  10. "Expression of the cell cycle regulatory proteins p34cdc2,p21waf1,and p53 in node negative invasive ductal breast carcinoma", 56, pp.328~35 (2003)
  11. "Role of the ubiquitin-proteasome pathway in regulating abundance of the cyclin-dependent kinase inhibitor p27", 269, pp.682~5 (1995)
  12. "Increased proteosome-dependent degradation of the cyclin-dependent kinase inhibitor p27 in aggressive colorectal carcinomas", 3, pp.231~4 (1997)
  13. "Prognostic significance of p27 expression in colorectal cancer", 18(23)
  14. "Significance of the expression of cyclin-dependent kinase inhibitor,p27kip1,in human breast cancer", 32, pp.1081~8 (1998)
  15. "Correlation between p53 and p27kip1 expression and clinicopathologic features in hepatocellular carcinoma", 32, pp.390~7 (2000)
  16. "A recombinant adenovirus expressing p27Kip1 induces cell cycle arrest and loss of cyclin-Cdk activity in human breast cancer cells", 14, pp.2283~9 (1997)
  17. "Decreased levels of the cell-cyclin inhibitor p27kip1 protein:prognostic implications in primary breast cancer", 3, pp.227~30 (1997)
  18. "TP53 tumor suppressor gene:a model for investigating human mutagenesis", 4, pp.1~15 (1992)
  19. "Quantitative p21(waf-1)", p53 immunohistochemical analysis defines groups of primary invasive breast carcinomas with different prognostic indicators, 2001, pp.95, 128~34
  20. "p21WAF1", CIP1 Codon 31 polymorphism in korean women:association with cervical cancer susceptibility and prognosis, 2000, pp.32, 1050~8
  21. "WAF1", Cip1 gene polymorphism and expression in carcinomas of the breast,ovary and endometrium, 1997, pp.150, 167~75
  22. "Prognostic value of p21 and p53 expression in breast carcinoma an immunohistochemical study in 261 patients with long-term follow-up", pp.1591~9, Clin Cancer Res 1996
  23. "Expression of cyclins in ductal hyperplasia,atypical ductal hyperplasia and ductal carcinoma in situ of the breast", 41, pp.345~53 (2000)
  24. "Elevated levels of p27,p21 and cyclin D1 correlate with positive oestrogen and progesterone receptor status in node-negative breast carcinoma patients", 435, pp.116~24 (1999)
  25. "Expression of p21Waf1,p27Kip1 and cyclin D1 proteins in breast ductal carcinoma in situ:Relation with clinicopathologic characteristics and with p53 expression and estrogen receptor status", 51, pp.94~9 (2001)
  26. "Hormone receptors and proliferation in breast carcinomas of equivalent histologic grades in pre- and postmenopausal women", 98, pp.118~27 (2002)

관련 논문AI추천

유방의 침윤성 관암종에서 p21, p53 및 bcl-2 단백의 발현문형배, 윤기중, 조향정대한병리학회 · Journal of Pathology and Translational Medicine2003 · 제37권 제6호유방암종에서 p27kip1 단백의 세포 내 발현 위치와 예후와의 관련성김대철, 조세헌, 홍숙희, 홍영습대한병리학회 · Journal of Pathology and Translational Medicine2006 · 제40권 제3호비소세포폐암종에서 Cyclin E 경로 단백들(cyclin E, cdk2,p21, p27, p57)의 발현 및 예후 지표 인자로서 의의강창석, 박경신, 변재호, 심상인, 이교영, 이명아, 이희정, 정지한, 정찬권대한병리학회 · Journal of Pathology and Translational Medicine2006 · 제40권 제1호위상피의 증식성 병변에서 p53, p21waf1/cip1, Cyclin D1 및 Rb 단백의 발현김형중, 박언섭, 유재형, 이태진대한병리학회 · Journal of Pathology and Translational Medicine2002 · 제36권 제4호유방암종에서 E2F4와 E2F2의 발현김은영, 이미자, 조현진대한병리학회 · Journal of Pathology and Translational Medicine2005 · 제39권 제5호난소 상피 종양에서 G1/S 세포주기 조절단백의 변화강현정, 김지연, 김활웅, 설미영, 신동훈, 이창훈, 최경운대한병리학회 · Journal of Pathology and Translational Medicine2006 · 제40권 제4호

이 간행물의 다른 논문 (9건)

Expression of Epidermal Growth Factor Receptor Related Proteinin Gallbladder Cancer: An Association with p53 Mutation이동근, 박호성, 강명재, 장규윤, 문우성, 김경열, 이학용, Majumdar Adhip P. N., Tarnawski Andrzej S.pp. 385-390유방암종에서 Vascular Endothelial Growth Factor-C 발현양선호, 이동근, 문우성, 장규윤, 강명재, 정명자pp. 401-405Renal Cell Carcinoma Associated with Xp11.2 Translocation:Clinicopathologic and Immunohistochemical Findings of 4 Cases권지은, 박상희, 서연림pp. 406-411비소세포 폐암종에서 Thymidylate Synthase의 발현김성환, 조덕곤, 김훈교, 유진영, 심병용, 송소향, 강석진, 김수지, 김치홍, 조규도, 안명임pp. 412-417The Expression of Matrix Metalloproteinase-9 and Tumor Angiogenesis in Human Osteosarcoma유진영, 이안희, 정지한, 강창석, 강석진, 서은주, 최현주, 심상인pp. 418-423
원문 보기