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난소 상피 종양에서 G1/S 세포주기 조절단백의 변화

Alteration of G1/S Cell Cycle Regulatory Proteins in Ovarian Epithelial Tumors

신동훈|강현정|이창훈|김지연|설미영|김활웅|최경운
대한병리학회|2006.08|Journal of Pathology and Translational Medicine|제40권 제4호|pp. 274-281

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참고문헌

주제분류병리학

초록

Abstract

Background : Disturbances of the cell cycle regulatory proteins are key events underlying the development and/or progression of human malignancies. The aim of this study was to evaluate the expression of G1/S cell cycle regulatory proteins in ovarian epithelial tumor. Methods : We simultaneously evaluated the expression of cyclin D1, cyclin E, CDK4, CDK2, p16, Rb, E2F1, p53 and the Ki67 labelling index (LI) by immunohistochemical methods in 148 cases of ovarian epithelial tumor of the benign (n=47), borderline (n=29), and malignant type (n=72). Results : The expression of cyclin E, CDK2, p16, Rb, E2F1, p53 and the Ki67 LI gradually increased from the benign type, through the borderline type, to the malignant tumors. Between the borderline and malignant tumors, the increased expression of cyclin E, E2F1, and p53, and the decreased expression of Rb were significantly associated with malignancy. The reduced Rb expression and the increased E2F1 expression were correlated with the FIGO stage and the histologic grade in the malignant ovarian epithelial tumors. Conclusions : Cyclin E, E2F1, and p53 overexpressions and the loss of Rb are the important components during carcinogenesis of ovarian epithelial tumors. Our results suggest that in- creased expression of E2F1 should be considered as a new parameter for the prognosis of patients with malignant ovarian epithelial tumors.

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상피성 난소암에서 핵 DNA 정량검사와 Cyclin A의예후적 의의김성훈, 김영태, 김재욱, 노종환, 이종승, 조남훈대한산부인과학회 · Obstetrics & Gynecology Science2004 · 제47권 제7호비소세포폐암종에서 c-kit와 세포주기 조절인자의 발현주미, 김한성, 장선희대한병리학회 · Journal of Pathology and Translational Medicine2006 · 제40권 제6호유방암종에서 p27kip1 단백의 세포 내 발현 위치와 예후와의 관련성김대철, 조세헌, 홍숙희, 홍영습대한병리학회 · Journal of Pathology and Translational Medicine2006 · 제40권 제3호세포주기와 관련된 유전자들의 난소 내 mRNA 및 단백질 발현박창은, 홍성노대한임상검사과학회 · 대한임상검사과학회지2006 · 제38권 제1호난소암에서 cyclin B1 및 D1 발현과임상 예후 인자들과의 관련성강명화, 김상운, 김성훈, 김영태, 김재욱, 김재훈, 김희연, 윤보성대한산부인과학회 · Obstetrics & Gynecology Science2005 · 제48권 제11호난소종양 환자에서 유세포분석을 통한 DNA 정량검사의예후적 의의김성훈, 김영태, 김재욱, 박기현, 이종승대한산부인과학회 · Obstetrics & Gynecology Science2004 · 제47권 제6호

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