위생검 조직에서 비정형 점막병변에 대한 GLUT1과 p53의 발현
Expressions of the GLUT1 and p53 Protein in Atypical Mucosal Lesions Obtained from Gastric Biopsy Specimens
2
조회
0
다운로드
0
인용
0
참고문헌
초록
Abstract
Background : The diagnosis of atypical mucosal lesions by performing hematoxylin-eosin staining is too subjective, and it is also subject to considerable inter-observer variation. There is a need for reliable immunohistochemical markers that can give reproducible results and that are not subject to individual interpretation. Methods : We reviewed a total of 199 cases of gastric biopsy specimens, which were all diagnosed as atypical mucosal lesions, and 124 cases of the adenocarcinomas specimens had been classified from category 1 (C1) to C5 according to the Vienna classification. We also examined the immunohistochemical expressions of the glucose transporter GLUT1 and the p53 protein in the gastric biopsy specimens to determine if they were useful markers for differentiatial diagnosis under the Vienna classifications. Results : None of the specimens in categories C1 to C3 showed GLUT1 expression, but 10.1% of the C4 specimens and 25.0% of the C5 specimens were GLUT1-positive (p<0.05). The expression of p53 was undetectable in the C1 specimens, but this was expressed in 2.9% of the C2 specimens, 15.6% of the C3 specimens, 37.8% of the C4 specimens, and 65.3% of the C5 specimens (p<0.05). Conclusions : The Vienna classification is very applicable to the gastric biopsy specimens of the atypical mucosal lesions, and the GLUT1 and p53 expressions are candidates as highly useful markers to differentiate the Vienna C4 lesions from the C3 and C5 lesions.
참고문헌 (18)
- "Review of histological classifications of gastrointestinal epithelial neoplasia:differences in diagnosis of early carcinomas between Japanese and Western pathologists", 36, pp.445~456 (2001)
- "Japanese classification of gastric carcinoma. 1st Ed.", pp.73~88 (1995)
- "Gastric dysplasia:the Padova international classification", 24, pp.167~176 (2000)
- "The Vienna classification of gastrointestinal epithelial neoplasia", 47, pp.251~255 (2000)
- "The new Vienna classification of epithelial neoplasia of the gastrointestinal tract:advantages and disadvantages", 442, pp.99~106 (2003)
- "Differential diagnosis of atypical epithelium of biopsied gastric mucosa using immunostaining of Ki-67,p53,hMLH1 and MDM2 expression", 21, pp.527~537 (2002)
- "Sugar and amino acid transport by cells in culturedifferences between normal and malignant cells", 286, pp.929~933 (1972)
- "Transformation of rat fibroblasts by FSV rapidly increases glucose transporter gene transcription", 235, pp.1495~8 (1987)
- "Overexpression of the human erythrocyte glucose transporter occurs as a late event in human colorectal carcinogenesis and is associated with an increased incidence of lymph node metastases", 2, pp.1151~1154 (1996)
- "Overexpression of Glut1 and Glut3 in stage I nonsmall cell lung carcinoma is associated with poor survival", 80, pp.1046~1051 (1997)
- "GLUT1 glucose transporter expression in colorectal carcinoma:a marker for poor prognosis", 83, pp.34~40 (1998)
- "Expression of facilitative glucose transporters in gastric tumors", 46, pp.2683~2689 (1999)
- "Expression of glucose transporter-1 in human gastric carcinoma:association with tumor aggressiveness,metastasis,and patient survival", 92, pp.634~641 (2001)
- "Expression of the human erythrocyte glucose transporter in transitional cell carcinoma of the bladder", 55, pp.448~452 (2000)
- "Expression of the GLUT1 glucose transporter in gallbladder carcinomas", 49, pp.907~911 (2001)
- "Cancer:p53,guardian of the genome", 358, pp.15~6 (1992)
- "Tissue microarray analysis of multiple gene expression in intestinal metaplasia,dysplasia and carcinoma of the stomach", 46, pp.505~514 (2005)
- "Pathology & genetics tumours of the digestive system." (2000)