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위 샘암종에서 cyclin E, p53, E-cadherin 및 β-catenin 발현의 의의

Significance of Cyclin E, p53, E-cadherin, and β-Catenin Expressions in Gastric Adenocarcinomas

이미자|서재홍|현용배
대한병리학회|2004.08|Journal of Pathology and Translational Medicine|제38권 제4호|pp. 213-220

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참고문헌

주제분류병리학

초록

Abstract

Background : Gastric cancer is reported to be one of the leading causes of mortality in Korea. Our aim was to evaluate the clinicopathologic usefulness of cyclin E, p53, E-cadherin and - catenin expressions in gastric adenocarcinomas. Methods : Immunohistochemical staining was performed on the 40 early gastric carcinoma (EGC) cases and 69 advanced gastric carcinoma (AGC) cases to examine the relationship with the clinicopathologic parameters. Results : Cyclin E and p53 expressions were significantly lower in the mucosal or submucosal invasion group compared with those in the muscle invasion and subserosal or serosal invasion groups. Cyclin E expression was significantly higher in the node-positive group compared with that in the node-negative group. The loss of -catenin expression was significantly higher in the nodenegative group. p53 expression was significantly higher in the intestinal type group than that in the diffuse type group. Loss of E-cadherin expression was significantly higher in the diffuse type group. Cyclin E expression correlates with p53 expression. Conclusions : The depth of invasion seems to correlate with cyclin E and p53 expressions. Lymph node metastasis may correlate with loss of -catenin expression.

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