방광에 생긴 미세유두변이 요로상피세포암종의 임상 및 병리학적 분석
Clinicopathologic Analysis of the Micropapillary Variant of Urothelial Carcinoma in Urinary
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Abstract
Background : Micropapillary urothelial carcinoma of urinary bladder is a rare and aggressive subtype of urothelial carcinoma (UC). Methods & Results : Seven UCs with a micropapillary component (MPC) were identified by reviewing 135 cystectomy specimens of UC (5.2% in incidence). MPC was associated with conventional UC in 6 cases and the plasmacytoid variant of UC in 1 case. Lymph node metastasis, that characteristically contained MPC was present in 60% (3 out of 5 cases of regional lymph node dissection). Three patients with extensive MPC showed laminar propria invasion (pT1; 33%) and perivesical fat invasion (pT3; 67%). Two out of 3 patients with extensive MPC showed distant metastasis into the colon after cystectomy. The colonic lesions showed exclusively micropapillary differentiation. Four patients with focal or moderate MPC (pT2, 25%; pT3, 75%) were alive without disease at the time of writing this article. All 3 cases with extensive MPC had surface and/or invasive MPC on the prior TURB specimen. Immunohistochemically, the tumor cells were positive for cytokeratin 7, cytokeratin 20, EMA and E-cadherin and tissue retraction spaces that simulate lymphatic spaces were negative for CD34 in all 7 cases. Conclusions : This study suggests that the micropapillary growth pattern in UC is a manifestation of aggressive behavior and UC with MPC must be included as part of the differential diagnosis when dealing with a metastatic lesion with a micropaillary structure.
참고문헌 (22)
- "Micropapillary bladder carcinoma:a clinicopathological study of 20 cases", 161, pp.1798~1802 (1999)
- "Micropapillary variant of transitional cell carcinoma of the urinary bladder", 18, pp.1224~32
- "Micropapillary variant of urothelial carcinoma of the urinary bladder;a clinicopathological and immunohistochemical study", 45, pp.55~64 (2004)
- "World health organization classification of tumours", pp.89~120 (2004), IARC Press
- "Urologic surgical pathology", pp.216~353 (1997), Mosby
- "Carcinomas with micropapillary morphology clinical significance and current concepts", 11, pp.297~303 (2004)
- "Clinical and pathological characteristics of micropapillary transitional cell carcinoma:a highly aggressive variant", 163, pp.748~751 (2000)
- "Invasive micropapillary carcinoma of the breast", 6, pp.660~662 (1993)
- "Invasive micropapillary carcinoma of the breast", 190, pp.668~74 (1994)
- "Micropapillary component in lung adenocarcinoma:a distinctive histological feature with possible prognostic significance", 26, pp.358~364 (2002)
- "Invasive micropapillarysalivary duct carcinoma:a distinct histologic variant with biologicsignificance", 28, pp.319~326 (2004)
- "Subclassification of serous borderline tumors of the ovary into benign and malignant types", 20, pp.1331~1345 (1996)
- "Invasive micropapillary carcinoma of the breast:clinicopathological and immunohistochemical study", 54, pp.90~96 (2004)
- "Invasive micropapillary carcinoma of the breast:clinicopathologic study of 62 cases of a poorly recognized variant with highly aggressive behavior", 121, pp.857~866 (2004)
- "Breast carcinomas with an unexpected inside-out growth pattern", 189 (1993)
- "Pathogenesis of invasive micropapillary carcinoma:role of MUC1 gycoprotein", 17, pp.1045~1050 (2004)
- "Infiltrating micropapillary carcinoma of the breast", 12, pp.499~504 (1999)
- "Clinicopathologic analysis of invasive micropapillary differentiation in breast carcinoma", 14, pp.836~841 (2001)
- "Invasive micropapillary carcinoma of the breast:eighty cases of an underrecognized entity", 32, pp.583~589 (2001)
- "Micropapillary carcinoma of the urothelial tract", 9, pp.1~5 (2005)
- "A micropapillary variant of transitional cell carcinoma arising in the ureter", 124, pp.1347~1348 (2000)
- "Uterine papillary serous carcinoma;a highly malignant form of endometrial adenocarcinoma", 6, pp.93~108 (1982)