Cytological Findings of the Micropapillary Variant of Urothelial Carcinoma: A Comparison with Typical High-Grade Urothelial Carcinoma
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Background: Micropapillary variant of urothelial carcinoma (MPUC) showed distinct pathologic features and aggressive behavior. The cytologic findings of MPUC are still indistinct. In this study, we evaluated the cytological findings of MPUC compared with those of high-grade urothelial carcinoma (HGUC). Methods: The voided urine cytology of 8 cases of MPUC and 8 cases of HGUC was reviewed. Following cytological parameters were evaluated: cellularity, background, number of small, tight papillary clusters, small acinar structure, scattered single cells, cytoplasmic features, nuclear-to-cytoplasmic ratio, nuclear pleomorphism, nuclear membrane irregularity, hyperchromasia, chromatin pattern and nucleoli. Results: Compared to that of HGUC, cytology of MPUC showed large numbers of small, tight papillary clusters, small acinar structure, few numbers of single cells, and hyperchromatic nuclei. Other parameters were similar between the two groups; both groups showed similar cellularity, dense or vacuolated cytoplasm, moderate to severe nuclear pleomorphism, irregular nuclear membrane, coarse granular chromatin, and small and prominent nucleoli. Conclusions: The urine cytology of MPUCs showed smaller and tighter papillary cell clusters, more small acinar structures, fewer numbers of scattered single cells, and more hyperchromatic nuclei. Than that of HGUC these features can help to distinguish MPUC and HGUC and offer an early cytological diagnosis of MPUC.
Abstract
Background: Micropapillary variant of urothelial carcinoma (MPUC) showed distinct pathologic features and aggressive behavior. The cytologic findings of MPUC are still indistinct. In this study, we evaluated the cytological findings of MPUC compared with those of high-grade urothelial carcinoma (HGUC). Methods: The voided urine cytology of 8 cases of MPUC and 8 cases of HGUC was reviewed. Following cytological parameters were evaluated: cellularity, background, number of small, tight papillary clusters, small acinar structure, scattered single cells, cytoplasmic features, nuclear-to-cytoplasmic ratio, nuclear pleomorphism, nuclear membrane irregularity, hyperchromasia, chromatin pattern and nucleoli. Results: Compared to that of HGUC, cytology of MPUC showed large numbers of small, tight papillary clusters, small acinar structure, few numbers of single cells, and hyperchromatic nuclei. Other parameters were similar between the two groups; both groups showed similar cellularity, dense or vacuolated cytoplasm, moderate to severe nuclear pleomorphism, irregular nuclear membrane, coarse granular chromatin, and small and prominent nucleoli. Conclusions: The urine cytology of MPUCs showed smaller and tighter papillary cell clusters, more small acinar structures, fewer numbers of scattered single cells, and more hyperchromatic nuclei. Than that of HGUC these features can help to distinguish MPUC and HGUC and offer an early cytological diagnosis of MPUC.
참고문헌 (16)
- Amin MB, "Micropapillary variant of transitional cell carcinoma of the urinary bladder: histologic pattern resembling ovarian papillary serous carcinoma", Am J Surg Pathol, 18, pp.1224~1232 (1994)
- Amin MB, "Histological variants of urothelial carcinoma: diagnostic, therapeutic and prognostic implications", Mod Pathol, 22(Suppl 2), pp.96~118 (2009)
- Kamat AM, "Micropapillary bladder cancer: a review of the University of Texas M. D. Anderson Cancer Center experience with 100 consecutive patients", Cancer, 110, pp.62~67 (2007)
- Zhu B, "Urine cytomorphology of micropapillary urothelial carcinoma", Diagn Cytopathol, 41, pp.485~491 (2013)
- Ylagan LR, "Micropapillary variant of transitional cell carcinoma of the urinary bladder: a report of three cases with cytologic diagnosis in urine specimens", Acta Cytol, 45, pp.599~604 (2001)
- 이영석, "방광의 미세유두형 요로상피암종의 세포소견 －1예 보고－", 대한세포병리학회지, 17(1), pp.46~50 (2006), 대한세포병리학회
- Lee JI, "Micropapillary carcinoma of the urinary bladder: a case report", Acta Cytol, 53, pp.344~348 (2009)
- Nicolas MM, "Micropapillary carcinoma of the urinary bladder: report of a case and review of its cytologic features", Diagn Cytopathol, 39, pp.784~787 (2011)
- Sakuma T, "Urine cytology of micropapillary carcinoma of the urinary bladder", Diagn Cytopathol, 39, pp.852~856 (2011)
- Divya K, "Fine needle aspiration cytology of a case of micropapillary variant of urothelial carcinoma of bladder", J Cytol, 28, pp.127~130 (2011)
- Bardales RH, "Practical urologic cytopathology", pp.181~189 (2002), Oxford University Press
- Nassar H, "Pathogenesis of invasive micropapillary carcinoma: role of MUC1 glycoprotein", Mod Pathol, 17, pp.1045~1050 (2004)
- Sangoi AR, "Immunohistochemical comparison of MUC1, CA125, and Her2Neu in invasive micropapillary carcinoma of the urinary tract and typical invasive urothelial carcinoma with retraction artifact", Mod Pathol, 22, pp.660~667 (2009)
- Samaratunga H, "Micropapillary variant of urothelial carcinoma of the urinary bladder; a clinicopathological and immunohistochemical study", Histopathology, 45, pp.55~64 (2004)
- Perepletchikov AM, "Micropapillary urothelial carcinoma: clinico-pathologic review", Pathol Res Pract, 205, pp.807~810 (2009)
- Compérat E, "Micropapillary urothelial carcinoma of the urinary bladder: a clinicopathological analysis of 72 cases", Pathology, 42, pp.650~654 (2010)