본문 바로가기
KERD
논문KCI 등재

골거대세포종에서 혈관신생과 VEGF 및 MMP-9의 발현과 임상양상의 상관성에 관한 연구

Expression of VEGF, MMP-9 and Neovascularization inRelationship to the Clinical Behavior of Giant Cell Tumorsof Bone

정상우|이재혁|한창우|김성순|정성택|이경화|심민근|김조헌
대한병리학회|2006.12|Journal of Pathology and Translational Medicine|제40권 제6호|pp. 420-426

2

조회

0

다운로드

1

인용

0

참고문헌

주제분류병리학

초록

Abstract

Giant cell tumors (GCTs) of bone are benign but can be locally aggressive neoplasms. Their clinical behavior has been difficult to predict on the basis of histology alone. This study investigated the neovascularization and expression of vascular endothelial growth factor (VEGF) as well as matrix metalloproteinase-9 (MMP-9) in GCTs of bone; in addition we evaluated their relationship to clinical behavior. Methods : We evaluated the microvessel number and density in 33 samples of giant cell tumor using CD34 immunohistochemistry. In addition, we examined the immunohistochemical expression of VEGF and MMP-9. Results : The microvessel number alone, not the microvessel density, had statistical association with the clinical stage of GCTs (p=0.045). The proportion of cases with strong expression of VEGF increased with advancing clinical stage, however, these results were not statistically significant (p=0.257). The percentage of the cases with strong expression of MMP-9 also increased with advancing clinical stage and this was statistically significant (p=0.022). Conclusions : These results suggest that intratumor microvessel count and the expression of MMP-9 correlate with GCT stage. Evaluation of their expression may therefore provide prognostic information on the aggressive behavior of GCTs of bone.

참고문헌 (24)

  1. "Late recurrence of giant-cell tumor of bone", 76, pp.1231~3 (1994)
  2. "Metastases from histologicallybenign giant-cell tumor of bone", 66, pp.269~74 (1984)
  3. "Giant cell tumor of bone", 19, pp.64~8 (1993)
  4. "Angiography ingiant-cell bone tumors", 130, pp.323~31 (1979)
  5. "Gene expression of vascular endothelialgrowth factor in giant cell tumors of bone", 31, pp.804~812 (2000)
  6. "Expression of VEGF and MMP-9 in giant cell tumor of bone andother osteolytic lesions", 73, pp.1427~1436 (2003)
  7. "Vascularendothelial growth factor is a secreted angiogenic mitogen", 246, pp.1306~9 (1989)
  8. "Matrix metalloproteinase 9 andvascular endothelial growth factor are essential for osteoclast recruitmentinto developing long bones", 151, pp.879~889 (2000)
  9. "Matrix metalloproteinases are obligatory forthe migration of preosteoclasts to the developing marrow cavity ofprimitive long bones", 108, pp.3649~3659 (1995)
  10. "MMP-9", gelatinase B is a keyregulator of growth plate angiogenesis and apoptosis of hypertrophicchondrocytes, 1998, pp.93, 411~422
  11. "A system of staging musculoskeletal neoplasms", 204, pp.9~24 (1986)
  12. "Microvessel quantitation and prognosis in invasive breast carcino-ma", 23, pp.755~61 (1992)
  13. "Human giant celltumors of bone identification and characterization of cell types", 79, pp.483~91 (1987)
  14. "Gene expression of monocyte chemoattractant protein-1 in giantcell tumors of bone osteoclastoma:possible involvement in CD68+macrophage-like cell migration", 70, pp.121~129 (1998)
  15. "Monocyte-macrophagelineage of giant cell tumor of bone", 71, pp.1751~60 (1993)
  16. "Expression of vascular permeabilityfactor(vascular endothelial growth factor)and its receptorsin adenocarcinomas of the gastrointestinal tract", 53, pp.4727~35
  17. "Vascular endothelialgrowth factor and glioma angiogenesis:coordinate inductionof VEGF receptors,distribution of VEGF protein and possiblein vivo regulatory mechanisms", 59, pp.520~9 (1994)
  18. "Proliferation index and vascular density of giant cell tumors of bone:are they prognostic markers", 77, pp.2044~2051 (1996)
  19. "Vascular endothelial growthfactor is a potential tumour angiogenesis factor in human gliomasin vivo", 359, pp.845~8 (1992)
  20. "Vascular permeabilityfactor", vascular endothelial growth factor,microvascular hyperpermeability,and angiogenesis, 1995, pp.146, 1029~1039
  21. "Matrix metalloproteinase 9(gelatinaseB)is expressed in multinucleated giant cells of human giantcell tumor of bone and is associated with vascular invasion", 148, pp.611~622 (1996)
  22. "Independent expression and cellular processing of Mr 72,000type IV collagenase and interstitial collagenase in human tumorigeniccell lines", 50, pp.6184~91 (1990)
  23. "Expression ofmetalloproteinases and tissue inhibitors of metalloproteinases ingiant cell tumor of bone:an immunohistochemical study with clinicalcorrelation", 27, pp.1144~1148 (1996)
  24. "Expressionand localization of extracellular matrix metalloproteinase inducerin giant cell tumor of bone", 89, pp.1154~1163 (2003)

관련 논문AI추천

The Expression of Matrix Metalloproteinase-9 and Tumor Angiogenesis in Human Osteosarcoma강석진, 강창석, 서은주, 심상인, 유진영, 이안희, 정지한, 최현주대한병리학회 · Journal of Pathology and Translational Medicine2005 · 제39권 제6호유방암종의 MMP-2와 MMP-9 발현과 예후 인자와의 연관성박설미, 윤혜경대한병리학회 · Journal of Pathology and Translational Medicine2004 · 제38권 제2호거대세포종과 유사한 역분화 부분을 가지는 연골육종 -1예 보고-김민아, 김종재, 김한수, 원재경, 이상훈, 황필규대한병리학회 · Journal of Pathology and Translational Medicine2004 · 제38권 제5호간세포암종의 혈관신생에서 Angiostatin, Vascular Endothelial Growth Factor, Matrix Metalloproteinase-9 및 12의 역할김숙, 문우성, 박호성, 손현진대한간학회 · Clinical and Molecular Hepatology2004 · 제10권 제2004호Expression of Matrix Metalloproteinase-9 Correlates with Poor Prognosis in Human Malignant Fibrous HistiocytomaChang Suk Kang, Ji Han Jung, Jinyoung Yoo, Seok Jin Kang대한암학회 · Cancer Research and Treatment2004 · 제36권 제6호자궁경부암으로의 진행에 따른vascular endothelial growth factor (VEGF),matrix metalloproteinases (MMPs)의 발현조용, 노의선, 박영한, 유선영, 이용우, 임소이, 최영희대한산부인과학회 · Obstetrics & Gynecology Science2008 · 제51권 제5호

이 간행물의 다른 논문 (11건)

큰세포역형성림프종의 ALK 표현을 포함한 임상병리학상 상관관계정수영, 고재수, 유한석, 류백렬, 이승숙pp. 399-405경직장초음파유도 전립샘침생검 1,000예의 병리학적 검색:새로운 검체처리 방법의 수립 및 면역조직화학검사의 유용성 평가정진행, 현창림, 박소연, 김혜령, 이희은, 이혜승, 최기영pp. 406-419비소세포폐암종에서 c-kit와 세포주기 조절인자의 발현장선희, 김한성, 주미pp. 427-431담낭암종에서의 p53, Heat Shock Protein 70과 TopoisomeraseIIα 의 발현정진숙, 김대철, 노미숙pp. 432-438자궁경부 세포진 검사 이상과 자궁경부 종양 소견을 보인 환자에게서 제한효소질량다형성 분석과 DNA chip을 통한 인유두종 바이러스 유전자형 검사의 유용성 비교김성남, 정현재, 지미선, 김수옥, 황선영, 김민아, 이은희, 홍성표, 조희정pp. 439-447
원문 보기