위암에서 Epstein-Barr Virus 연관성의 예측 인자
Predictive Factors of Epstein-Barr Virus Association in Gastric Adenocarcinoma
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Abstract
Background : It is important to detect Epstein-Barr virus (EBV) in the setting of gastric cancer so that early viral targeted therapy and prevention can be undertaken. The aim of this study was to investigate the predictive clinicopathologic factors for EBV-related gastric cancer. Methods : The archival tumor tissues from 335 patients with gastric cancer were examined using tissue microarray. The detection of EBV was performed using EBV mRNA in situ hybridization (EBV-ISH), and the results were compared against clinicopathologic factors. Results : EBV-related gastric cancers were identified in 21 of 335 investigated cases (6.27%). The anatomical predisposition of EBV-related cancers to manifest in the upper stomach was statistically significant (p<0.001). EBV-related cancers were almost always (20/21) accompanied by lymphoid stroma. No differences in age, sex, histologic differentiation, or T or N stage were noted between EBV-positive and EBV-negative gastric carcinomas. Conclusions : The association of EBV with gastric adenocarcinomas could be predicted when tumors with lymphoid stroma occurred in the upper stomach.
참고문헌 (18)
- "Cancer registry system in Korea"[URL]
- Shibata D, "Epstein-Barr virus-associated gastric adenocarcinoma", Am J Pathol, 140, pp.769~774 (1992)
- Rawlands DC, "Epstein-Barr virus and carcinomas: rare association of the virus with gastric adenocarcinomas", Br J Cancer, 68, pp.1014~1019 (1993)
- Sixbey JW, "Epstein- Barr virus replication in oropharyngeal epithelial cells", N Engl J Med, 310, pp.1225~1230 (1984)
- Watanabe H, "Gastric carcinoma with lymphoid stroma: its morphologic characteristics and prognostic correlations", Cancer, 38, pp.232~243 (1976)
- Oda K, "Association of Epstein-Barr virus with gastric carcinoma with lymphoid stroma", Am J Pathol, 143, pp.1063~1071 (1993)
- Labrecque LG, "Epstein-Barr virus in epithelial cell tumors: a breast cancer study", Cancer Res, 55, pp.39~45 (1995)
- Sugawara Y, "Detection of Epstein-Barr virus (EBV) in hepatocellular carcinoma tissue: a novel EBV latency characterized by the absence of EBV-associated small RNA expression", Virology, 256, pp.196~202 (1999)
- Chang MS, "Clinicopathologic characteristics of Epstein-Barr virus-incorporated gastric cancers in Korea", Pathol Res Pract, 197, pp.395~400 (2001)
- Shin WS, "Epstein-Barr virus- associated gastric adenocarcinomas among Koreans", Am J Clin Pathol, 105, pp.174~181 (1996)
- Adachi Y, "Epstein-Barr virus-associated gastric carcinoma", J Clin Gastroenterol, 23, pp.207~210 (1996)
- Ueo T, "Coexistence of Epstein-Barr virus-associated gastric carcinoma with malignant lymphoma: report of two cases", Virchows Arch, 449, pp.215~219 (2006)
- Koriyama C, "Environmental factors related to Epstein-Barr virus-associated gastric cancer in Japan", J Exp Clin Cancer Res, 24, pp.547~553 (2005)
- International Agency for Research on Cancer, "Epstein-Barr virus and Kaposi’s sarcoma Herpesvirus", Human Herpesvirus 8, 1997
- Raab-Traub N, "The differentiated form of nasopharyngeal carcinoma contains Epstein-Barr virus DNA", Int J Cancer, 39, pp.25~29 (1987)
- Jones JF, "T-cell lymphomas containing Epstein-Barr viral DNA in patients with chronic Epstein-Barr virus infections", N Engl J Med, 318, pp.733~741 (1988)
- Hawley RC, "Angioimmunoblastic T-cell lymphoma with supervening Epstein-Barr virus-associated large B-cell lymphoma", Arch Pathol Lab Med, 130, pp.1707~1711 (2006)
- Luo B, "Expression of Epstein-Barr virus genes in EBV-associated gastric carcinomas", World J Gastroenterol, 11, pp.629~633 (2005)