미세먼지와 보통형 간질폐렴의 상관 관계
Birefringent Particles as an Effective Factor in Usual Interstitial Pneumonia
1
조회
0
다운로드
0
인용
0
참고문헌
초록
Abstract
Background : It has long been recognized that birefringent paticles (BP) are associated with pulmonary disease. And there is increasing evidence that BP cause fibrotic reaction within the lung depending on both particle size and composition. Methods : We collected 41 cases of usual interstitial pneumonia (UIP) and 101 cases of normal lung tissue from control group including squamous cell carcinoma, adenocarcinoma and bullae. BPs in the 0.1 to 10 μm size range under polarizing microscope was measured and counted by image analyzer. Results : BP counts are mean 244.05/10 HPF in UIP and 71.4/10 HPF in control group. BPs in UIP is three times more than control (p=0.000). It increased significantly by the age of patients (p=0.000). Conclusions : BPs in lung might be important cause of inflammation and fibrosis in UIP.
참고문헌 (8)
- Churg A, "Airway wall remodeling induced by occupational mineral dusts and air pollutant particles", Chest, 122, pp.306~309 (2002)
- Barbarin V, "The role of pro- and antiinflammatory responses in silica-induced lung fibrosis", Respir Res, 6, pp.112~ (2005)
- O’Reilly KM, "Crystalline and amorphous silica differentially regulate the cyclooxygenase- prostaglandin pathway in pulmonary fibroblasts: implications for pulmonary fibrosis", Am J Physiol Lung Cell Mol Physiol, 288, pp.1010~1016 (2005)
- Schwartz J, "Particulate air pollution and chronic respiratory disease", Environ Res, 62, pp.7~13 (1993)
- Erikson KM, "Manganese exposure and induced oxidative stress in the rat brain", Sci Total Environ, pp.409~416 (2004)
- American Thoracic Society, "Idiopathic pulmonary fibrosis: diagnosis and treatment. International consensus statement. American Thoracic Society (ATS), and the European Respiratory Society (ERS)", Am J Respir Crit Care Med, 161, pp.646~664 (2000)
- Stacey E, "Histology for pathologist. In: Stacey E, Mills M, eds. Histology for pathologist. 3rd ed", pp.1271~ (2007), Lippincott Williams & Wilkins, a Wolters Kluwer business
- Bonner JC, "Lung fibrotic responses to particle exposure", Toxicol Pathol, 35, pp.148~153 (2007)