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Malignant Fibrous Histiocytoma Arising in a Mature Cystic Teratoma of the Ovary - A Case Report -

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초록

A 50-year-old female patient presented with anorexia and weight loss. Pelvic computed tomography revealed a 12.5 × 7.3 cm heterogeneous mass in the left ovary. About 30% of the tumor was occupied by a mature cystic teratoma. The remaining solid portion was composed of fibrous and histiocytic elements, arranged in storiform patterns admixed with bizarre giant cells. The mitotic index was 8 per 10 high power fields, including atypical mitoses. The only immunopositivity was for vimentin. The tumor was diagnosed as a malignant fibrous histiocytoma arising in a mature cystic teratoma. To the best of our knowledge, this is only the third such case in the English language literature.

Abstract

A 50-year-old female patient presented with anorexia and weight loss. Pelvic computed tomography revealed a 12.5 × 7.3 cm heterogeneous mass in the left ovary. About 30% of the tumor was occupied by a mature cystic teratoma. The remaining solid portion was composed of fibrous and histiocytic elements, arranged in storiform patterns admixed with bizarre giant cells. The mitotic index was 8 per 10 high power fields, including atypical mitoses. The only immunopositivity was for vimentin. The tumor was diagnosed as a malignant fibrous histiocytoma arising in a mature cystic teratoma. To the best of our knowledge, this is only the third such case in the English language literature.

참고문헌 (11)

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  2. Weiss SW, "Enzinger & Weiss’s soft tissue tumor. 5th ed", pp.545~555 (2008), Mosby
  3. Weiss SW, "Enzinger & Weiss’s soft tissue tumor. 5th ed", pp.614~617 (2008), Mosby
  4. Weiss SW, "Enzinger & Weiss’s soft tissue tumor. 5th ed" (2008), Mosby
  5. Rim SY, "Malignant transformation of ovarian mature cystic teratoma", Int J Gynecol Cancer, 16, pp.140~144 (2006)
  6. Ueda G, "Malignant fibrous histiocytoma arising in a benign cystic teratoma of the ovary", Gynecol Oncol, 5, pp.313~322 (1977)
  7. Hanada M, "Multiple malignancies(squamous cell carcinoma and sarcoma)arising in a dermoid cyst of the ovary", Acta Pathol Jpn, 31, pp.681~688 (1981)
  8. Yamakawa Y, "Inflammatory malignant fibrous histiocytoma of the ovary producing interleukin-6:a case report", Gynecol Oncol, 75, pp.484~489 (1999)
  9. Dilek TU, "Malignant fibrous histiocytoma of the ovary:a case report", Int J Gynecol Cancer, 16(Suppl,1), pp.352~356 (2006)
  10. Devouassoux-Shisheboran M, "Teratomatous genotype detected in malignancies of a non-germ cell phenotype", Lab Invest, 80, pp.81~86 (2000)
  11. Arora DS, "Carcinosarcoma arising in a dermoid cyst of the ovary", J Clin Pathol, 49, pp.519~521 (1996)

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