Urothelial (Transitional Cell) Carcinoma Arising in Mature Cystic Teratoma - A Case Report -
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Mature cystic teratoma (MCT) is one of the most common benign ovarian tumors, but 1-2% of MCTs are transformed to a malignant neoplasm. Urothelial carcinoma (UC) or transitional cell carcinoma is the most common cancer in the urinary tract. However, UC is a very rare component of transformed malignancy of MCT. Here we report a case of UC arising in an MCT in a 52-year-old woman. Grossly, the ovary was partly cystic and partly solid. Microscopically, the cyst revealed the classic features of MCT and the solid area was papillary UC. By immunohistochemistry using cytokeratins and thrombomodulin, the UC showed a similar expression to that of UC arising in the urinary tract, rather than resembling a primary transitional cell carcinoma of the ovary. When UC is found in a component of MCT, the origin of the carcinoma should be evaluated and urinary tract examinations are required to rule out metastasis.
Abstract
Mature cystic teratoma (MCT) is one of the most common benign ovarian tumors, but 1-2% of MCTs are transformed to a malignant neoplasm. Urothelial carcinoma (UC) or transitional cell carcinoma is the most common cancer in the urinary tract. However, UC is a very rare component of transformed malignancy of MCT. Here we report a case of UC arising in an MCT in a 52-year-old woman. Grossly, the ovary was partly cystic and partly solid. Microscopically, the cyst revealed the classic features of MCT and the solid area was papillary UC. By immunohistochemistry using cytokeratins and thrombomodulin, the UC showed a similar expression to that of UC arising in the urinary tract, rather than resembling a primary transitional cell carcinoma of the ovary. When UC is found in a component of MCT, the origin of the carcinoma should be evaluated and urinary tract examinations are required to rule out metastasis.
참고문헌 (13)
- Medeiros F, "Germ cell tumors of the ovary. In: Diagnostic gynecologic and obstetric pathology", pp.913~944 (2006), Elsevier-Saunders Inc.
- Rim SY, "Malignant transformation of ovarian mature cystic teratoma", Int J Gynecol Cancer, 16, pp.140~144 (2006)
- Murphy WM, "Tumors of the kidney, bladder, and related urinary structures", pp.241~361 (2004), American Registry of Pathology
- Kido A, "Dermoid cysts of the ovary with malignant transformation:MR appearance", AJR Am J Roentgenol, 172, pp.445~449 (1999)
- Lee HH, "A case of papillary transitional cell carcinoma arising from the benign cystic teratoma of ovary", Korean J Obstet Gynecol, 42, pp.1123~1126 (1999)
- Al-Rayyan ES, "Secondary malignancies in ovarian dermoid cyst", Saudi Med J, 30, pp.524~528 (2009)
- Iwasa A, "Squamous cell carcinoma arising in mature cystic teratoma of the ovary:an immunohistochemical analysis of its tumorigenesis", Histopathology, 51, pp.98~104 (2007)
- Kikkawa F, "Diagnosis of squamous cell carcinoma arising from mature cystic teratoma of the ovary", Cancer, 82, pp.2249~2255 (1998)
- Dos Santos L, "Squamous cell carcinoma arising in mature cystic teratoma of the ovary:a case series and review of the literature", Gynecol Oncol, 105, pp.321~324 (2007)
- Eichhorn JH, "Transitional cell carcinoma of the ovary:a morphologic study of 100 cases with emphasis on differential diagnosis", Am J Surg Pathol, 28, pp.453~463 (2004)
- Ordonez NG, "Transitional cell carcinomas of the ovary and bladder are immunophenotypically different", Histopathology, 36, pp.433~438 (2000)
- Parker DC, "Potential utility of uroplakin III,thrombomodulin,high molecular weight cytokeratin,and cytokeratin 20 in noninvasive,invasive,and metastatic urothelial(transitional cell)carcinomas", Am J Surg Pathol, 27, pp.1~10 (2003)
- Logani S, "Immunoprofile of ovarian tumors with putative transitional cell(urothelial)differentiation using novel urothelial markers:histogenetic and diagnostic implications", Am J Surg Pathol, 27, pp.1434~1441 (2003)