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질에 발생한 방추세포상피종(양성혼합종양) 1예

Spindle Cell Epithelioma, a So-called Benign Mixed Tumor of the Vagina - A Case Report -

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초록

We report a case of spindle cell epithelioma, a so-called benign mixed tumor of the vagina. The patient was a 35-year-old nulliparous woman who presented with a polypoid mass in the posterior wall of the lower vagina just above the hymenal ring. The tumor was relatively welldefined with an expansile margin and composed of stromal-type spindle cells with a myxoid stroma arranged in short fascicles and an irregular cord-like or reticular pattern. A few glandular structures lined by cuboidal cells with squamous metaplasia were also noted. Cellular atypia was not conspicuous and mitosis was not found. We examined this tumor immunohistochemically to identify the histogenesis. The coexpression of epithelial and mesenchymal markers in stromal-type spindle cells suggested a multipotential cell origin for this tumor. The patient has been well with no signs of recurrence during the 12 months after surgery.

Abstract

We report a case of spindle cell epithelioma, a so-called benign mixed tumor of the vagina. The patient was a 35-year-old nulliparous woman who presented with a polypoid mass in the posterior wall of the lower vagina just above the hymenal ring. The tumor was relatively welldefined with an expansile margin and composed of stromal-type spindle cells with a myxoid stroma arranged in short fascicles and an irregular cord-like or reticular pattern. A few glandular structures lined by cuboidal cells with squamous metaplasia were also noted. Cellular atypia was not conspicuous and mitosis was not found. We examined this tumor immunohistochemically to identify the histogenesis. The coexpression of epithelial and mesenchymal markers in stromal-type spindle cells suggested a multipotential cell origin for this tumor. The patient has been well with no signs of recurrence during the 12 months after surgery.

참고문헌 (11)

  1. Branton PA, "Spindle cell epithelioma,the so-called mixed tumor of the vagina:a clinicopathologic,immunohistochemical,and ultrastructural analysis of 28 cases", Am J Surg Pathol, 17, pp.509~515 (1993)
  2. Brown CE, "Mixed epithelial tumor of the vagina", Am J Clin Pathol, 23, pp.237~240 (1953)
  3. Oliva E, "Mixed tumors of the vagina:an immunohistochemical study of 13 cases with emphasis on the cell of origin and potential aid in differential diagnosis", Mod Pathol, 17, pp.1243~1250 (2004)
  4. Malik AK, "Spindle-cell epithelioma:"mixed tumor"of the vagina", Ann Saudi Med, 22, pp.202~203 (2002)
  5. Murdoch F, "Benign mixed tumor of the vagina:case report with expanded immunohistochemical profile", Int J Gynecol Cancer, 13, pp.543~547 (2003)
  6. Park JS, "A case of benign mixed tumor of the vagina", Korean J Obstet Gynecol, 37, pp.1888~1893 (1994)
  7. Mi-SeonKang, "Mixed Tumor of the Vagina : A Case Report", Journal of Korean Medical Science, 17(6), pp.845~848 (2002), 대한의학회
  8. Skelton H, "Spindle cell epithelioma of the vagina shows immunohistochemical staining supporting its origin from a primitive", progenitor cell population, 2001, pp.125, 547~550
  9. van den Broek N, "Benign mixed tumour of the vagina:an unusual cause for postmenopausal bleeding", Eur J Obstet Gynecol Reprod Biol, 69, pp.143~144 (1996)
  10. Wright RG, "Recurrent benign mixed tumor of the vagina", Gynecol Oncol, 40, pp.84~86 (1991)
  11. Fukunaga M, "Mixed tumour of the vagina", Histopathology, 28, pp.457~461 (1996)

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