폐편평세포암종에서 Oct4 발현의 임상적 의의
Clinical Implication of Oct4 Expression in Squamous Cell Carcinoma of Lung
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Background : Octamer-4 (Oct4), a transcriptional factor involved in regulating embryonic stem cells, may play a role in tumorigenesis. Since little is known about the role of Oct4 as a prognostic factor for squamous cell carcinoma (SCC) of lung, we investigated its expression in SCC tissue and its clinicopathologic significance. Methods : Formalin-fixed, paraffin embedded tissues from 79 patients, including 44 complete resections and 35 biopsies, obtained from 1995 to 2008 were immunostained for Oct4, scored, and scores correlated with clinicopathologic parameters and survival. Results : Oct4 expression in tumors was significantly associated with peripheral location (vs central location) (p = 0.004) and pleural invasion (p = 0.018). In 44 complete resections, survival analysis revealed that Oct4 expression and increased stage (II and III vs I) were significantly associated with worse survival in univariate analysis (p = 0.005 and p = 0.009, respectively) and in multivariate analysis (p = 0.024 and p = 0.033, respectively). Conclusions : The expression of Oct4 and high stage in SCC of lung are significant predictors of a poor prognosis and diminished overall survival.
Abstract
Background : Octamer-4 (Oct4), a transcriptional factor involved in regulating embryonic stem cells, may play a role in tumorigenesis. Since little is known about the role of Oct4 as a prognostic factor for squamous cell carcinoma (SCC) of lung, we investigated its expression in SCC tissue and its clinicopathologic significance. Methods : Formalin-fixed, paraffin embedded tissues from 79 patients, including 44 complete resections and 35 biopsies, obtained from 1995 to 2008 were immunostained for Oct4, scored, and scores correlated with clinicopathologic parameters and survival. Results : Oct4 expression in tumors was significantly associated with peripheral location (vs central location) (p = 0.004) and pleural invasion (p = 0.018). In 44 complete resections, survival analysis revealed that Oct4 expression and increased stage (II and III vs I) were significantly associated with worse survival in univariate analysis (p = 0.005 and p = 0.009, respectively) and in multivariate analysis (p = 0.024 and p = 0.033, respectively). Conclusions : The expression of Oct4 and high stage in SCC of lung are significant predictors of a poor prognosis and diminished overall survival.
참고문헌 (26)
- Cersosimo RJ, "Lung cancer:a review", Am J Health Syst Pharm, 59, pp.611~642 (2002)
- Hammar SP, "Squamous cell carcinoma. In: Pathology and genetics of tumours of the lung, pleura, thymus, and heart", pp.26~30 (2004), IARC Press
- Auerbach O, "Histologic type of lung cancer in relation to smoking habits,year of diagnosis and sites of metastases", Chest, 67, pp.382~387 (1975)
- Jones DR, "Surgery for stage I non-small cell lung cancer. In: Diagnosis and treatment of lung cancer", pp.177~190 (2001), W.B. Saunders
- Moreira AL, "Progenitor stem cell marker expression by pulmonary carcinomas", Mod Pathol, 23, pp.889~895 (2010)
- Nichols J, "Formation of pluripotent stem cells in the mammalian embryo depends on the POU transcription factor Oct4", Cell, 95, pp.379~391 (1998)
- Dick JE, "Normal and leukemic human stem cells assayed in SCID mice", Semin Immunol, 8, pp.197~206 (1996)
- Trosko JE, "Ignored hallmarks of carcinogenesis:stem cells and cell-cell communication", Ann N Y Acad Sci, 1028, pp.192~201 (2004)
- Ratajczak MZ, "A hypothesis for an embryonic origin of pluripotent Oct-4(+)stem cells in adult bone marrow and other tissues", Leukemia, 21, pp.860~867 (2007)
- Gidekel S, "Oct-3", 4 is a dose-dependent oncogenic fate determinant, 2003, pp.4, 361~370
- Stephen BE, "Lung. In: AJCC cancer staging manual. 7th ed", pp.253~270 (2010), Springer
- Funai K, "Clinicopathologic characteristics of peripheral squamous cell carcinoma of the lung", pp.978~984 (2003), Am J Surg Pathol
- Karoubi G, "OCT4 expression in human non-small cell lung cancer:implications for therapeutic intervention", Interact Cardiovasc Thorac Surg, 8, pp.393~397 (2009)
- Enstrom JE, "Rising lung cancer mortality among nonsmokers", J Natl Cancer Inst, 62, pp.755~760 (1979)
- Marsden CG, "Breast tumorinitiating cells isolated from patient core biopsies for study of hormone action", Methods Mol Biol, 590, pp.363~375 (2009)
- Takaishi S, "Gastric cancer stem cells", J Clin Oncol, 26, pp.2876~2882 (2008)
- Bjerkvig R, "Opinion:the origin of the cancer stem cell:current controversies and new insights", Nat Rev Cancer, 5, pp.899~904 (2005)
- Hansis C, "Oct-4 expression in inner cell mass and trophectoderm of human blastocysts", Mol Hum Reprod, 6, pp.999~1004 (2000)
- Cheng L, "OCT,4,pp.biological functions and clinical applications as a marker of germ cell neoplasia", J Pathol, 211, pp.1~9 (2007)
- Schoenhals M, "Embryonic stem cell markers expression in cancers", Biochem Biophys Res Commun, 383, pp.157~162 (2009)
- Okamoto K, "A novel octamer binding transcription factor is differentially expressed in mouse embryonic cells", Cell, 60, pp.461~472 (1990)
- Cheng CJ, "Aberrant expression and distribution of the OCT-4 transcription factor in seminomas", J Biomed Sci, 14, pp.797~807 (2007)
- Saigusa S, "Correlation of CD133,OCT4,and SOX2 in rectal cancer and their association with distant recurrence after chemoradiotherapy", Ann Surg Oncol, 16, pp.3488~3498 (2009)
- Ben-Porath I, "An embryonic stem celllike gene expression signature in poorly differentiated aggressive human tumors", Nat Genet, 40, pp.499~507 (2008)
- Koch LK, "Stem cell marker expression in small cell lung carcinoma and developing lung tissue", Hum Pathol, 39, pp.1597~1605 (2008)
- Chen Z, "Oct4,a novel marker for human gastric cancer", J Surg Oncol, 99, pp.414~419 (2009)